MEDICINEnotes
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1 279
A 23-year-old recently married female presents to her family
doctor with a 6-week history of 3kg weight loss, an irregular
menstrual cycle and anxiety. She has a fear of general
anaesthesia due to a previous perioperative episode of
anaphylaxis. She and her husband are keen to start a family.
On examination a smooth goitre is palpable in her neck with
bruit detected on auscultation. Thyroid function tests show
TSH <0.01mIU/L (RR 0.2–4.5mIU/L), and free T4 36pmol/L
(RR 9–21 pmol/L. TSH receptor antibody (TRAb) is 14IU/L (RR
0–1.6 IU/L).
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Which investigation would best support the suspected precipitating factor for status epilepticus in this patient?
1 279
5. Which of the following would be the strongest indication for endotracheal intubation and ICU admission?
1 279
The patient continues to have generalized tonic-clonic seizure activity despite an adequate dose of IV lorazepam. Which of the following is the most appropriate next pharmacological treatment?
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3. What is the most appropriate first-line pharmacological treatment for this patient?
1 279
🧠 Case
A 24-year-old man is brought to the Emergency Department because of recurrent generalized tonic-clonic seizures.
According to his family, the first seizure started approximately 20 minutes ago. Since then, he has had repeated generalized tonic-clonic seizure activity with only brief intervals and without complete recovery of consciousness between episodes.
He is a known case of generalized epilepsy and has been prescribed sodium valproate, but his family reports that he has been poorly compliant with his medication over the last few days.
On examination:
GCS: E1 V1 M2
HR: 128 beats/min
BP: 140/90 mmHg
RR: 24 breaths/min
SpO₂: 92% on room air
Temperature: 37.2°C
Ongoing generalized tonic-clonic seizure activity
Pupils are equal and reactive
No obvious signs of head trauma or meningism
Focal neurological examination cannot be reliably assessed during the seizure
Initial investigations:
Random blood glucose: 7.2 mmol/L
CBC: within normal limits
Urea and creatinine: within normal limits
Na⁺: 138 mmol/L
K⁺: 3.8 mmol/L
Ca²⁺: 2.2 mmol/L
LFTs: within normal limits
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A 24-year-old woman was found to have mild hyperthyroidism due to Graves’ disease. She appears to be in good health otherwise.
In Graves’ disease, the cause of the hyperthyroidism is the production of an antibody that does which of the following?
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+1
قناة خاصة
فيها
. MCQs and cases
نظام القناة طريقة الاختبارات
حاليا فيها كورس Respiratory
وبدينا كورس Endocrinology
القناة تلاقي هاشتاق مثبت اسم الكورس
تحت الهاتشاق منشور يوضحلك الاسئلة من رقم كذا لكذا راهو COPD
ومن كذا لكذا Asthma
وكل بداية و نهاية موضوع رسالة مثبتة لاسم المرض عشان تقرا الكورس او جزء المعين وتختبر نفسك
للاستفسار والتواصل
@Ducktor47
1 279
+1
قناة خاصة
فيها
. MCQs and cases
نظام القناة طريقة الاختبارات
حاليا فيها كورس Respiratory
وبدينا كورس Endocrinology
القناة تلاقي هاشتاق مثبت اسم الكورس
تحت الهاتشاق منشور يوضحلك الاسئلة من رقم كذا لكذا راهو COPD
ومن كذا لكذا Asthma
وكل بداية و نهاية موضوع رسالة مثبتة لاسم المرض عشان تقرا الكورس او جزء المعين وتختبر نفسك
للاستفسار والتواصل
@Ducktor47
1 279
Which of the following is the most appropriate sequence of pharmacological management?
1 279
A 34-year-old woman is brought to the emergency department because of sudden agitation and confusion.
For the past 2 weeks, she has complained of worsening anxiety, heat intolerance, diarrhea, and difficulty sleeping. Her family mentions that she has lost weight despite having an increased appetite.
Three days ago, she was treated for a respiratory infection but stopped taking her usual medication because she "felt better."
On examination:
Temperature: 40.1°C
Heart rate: 162 bpm, irregular
Blood pressure: 148/70 mmHg
Respiratory rate: 28/min
She is restless and disoriented
Cardiac examination reveals an irregularly irregular rhythm.
She has a fine tremor and a diffusely enlarged thyroid gland.
Laboratory results:
TSH: undetectable
Free T4: markedly elevated
Free T3: elevated
An ECG shows atrial fibrillation with rapid ventricular response.
Despite initial supportive measures, her mental status deteriorates.
