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شوفوا يا جماعة الـ LAD
ينقسم Septal و Anterior
لو لقينا الـ ECG changes في
V1 - V2 = Septal
V3 - V4 = Anterior
لو لقيناه في VV1- V4
معناها Anteroseptal STEMI ونشكوا ان LAD متصكر
معناها الجزء المتضرر من القلب هو Left ventricle مع interventricluar septum
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What is the most appropriate next step to establish the ECG diagnosis?
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Q1096. A 63-year-old woman presents with two hours of central chest pain and sweating. Her pulse is 88 beats/min and blood pressure is 132/80 mmHg. The 12-lead ECG demonstrates 3 mm horizontal ST-segment depression in leads V1–V3, with tall, broad R waves and upright T waves in V2–V3. There is no ST-segment elevation in any of the 12 standard leads. These changes raise suspicion of an acute myocardial infarction that may be poorly represented on the standard ECG.
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Q1095. A 65-year-old man is admitted with an extensive anterior STEMI and undergoes successful primary PCI. On the third day, he suddenly develops severe breathlessness, hypotension and pulmonary oedema. His blood pressure is 82/54 mmHg, and a new harsh pansystolic murmur with a palpable thrill is heard along the lower left sternal border. Echocardiography identifies a new ventricular septal defect with left-to-right flow.
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لو الـ Patients من البداية مايتحملش
Metformin is not tolerated or contraindicated (CI)
Initial monotherapy
اختار واحد:
Gliptin.
Sulfonylurea.
Pioglitazone.
Dual therapy
إذا HbA1c أكبر من (7.5%):
Gliptin + Pioglitazone.
Gliptin + Sulfonylurea.
Pioglitazone + Sulfonylurea.
Insulin
If HbA1c remains greater than 58 mmol/mol (7.5%)
نتنقلوا للـ Insulin.
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#Metformin
First-line treatment.
1. Rule out renal failure (RF) before starting Metformin.
2. Reassess HbA1c after 3 months.
If HbA1c is greater than 58 mmol/mol (7.5%), add a second drug.
#Dual_therapy
اختار واحد من الاثنين اهما
Metformin + Gliptin.
Metformin + Sulfonylurea.
Metformin + Pioglitazone.
Metformin + SGLT-2 inhibitor.
Reassess HbA1c after 3 months.
If HbA1c remains greater than 58 mmol/mol (7.5%), proceed to Triple therapy.
#Triple_therapy
اختار واحد من الثلاثة اهما
Metformin + Gliptin + Sulfonylurea.
Metformin + Pioglitazone + Sulfonylurea.Metformin + Sulfonylurea + SGLT-2 inhibitor.
Metformin + Pioglitazone + SGLT-2 inhibitor.
If HbA1c remains above 7.5% despite triple therapy → Insulin therapy.
لو كانت Triple therapy:
Not effective.
Not tolerated.
Contraindicated.
AND BMI greater than 35.
نستخدموا:
Metformin + Sulfonylurea + GLP-1 mimetic.
