Доктор Довнар-Запольская
Блог педиатра, к.м.н., доцента Оксаны Николаевны Довнар - Запольской. Актуальное из мира педиатрии с позиции доказательной медицины
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Author summary Myocarditis is an inflammatory disease of the heart. Viruses or post-viral immune mediated response are the main causes of myocarditis. Human group B enteroviruses, specifically Coxsackievirus B3 (CVB3), are common infectious causes of acute myocarditis in the young. Early emergence and maintenance of major 5’terminally deleted RNA forms of CVB have been associated with acute and chronic myocarditis in both mice and humans. To achieve viral genome maintenance in the cardiac cells, viruses could modulate innate immunity activation. Here, we report on major early-emerging CVB3 populations deleted in the 5’non-coding region of viral genomic RNA that modulate the activation of the type I interferon pathway in cardiomyocytes and cause myocarditis in mice. Activating the innate immune sensors after CVB3 infection protects mice from CVB3-induced myocarditis and shall promote further studies in immunotherapies in viral acute and chronic myocarditis.
Emergency Radiology - To compare the performance of multiple international guidelines in selecting patients for head CT prior to lumbar puncture (LP) in suspected meningitis, focusing on...