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اسئلة د.عمار https://t.me/pharma89a/1748 اسئلة د.محمد https://t.me/pharma89a/1750 اسئلة د.زينب https://t.me/pharma89a/1752 ملخص محاضرات 8 - 9 - 10 د.زينب من دفعة 88🤍 https://t.me/pharma89a/1754 عسى ان تكون ختامها مسك all the best 🤍

Erythromycin: The amino sugar at c3 is cladinose and at c5 is desosamine Have irregular oral absorption and bitter taste Protein synthesis inhibitor

Clindamycin: Contain chlorine group at position 7 More potent than lincomycin Cause diarrhea Inhibit protein synthesis Contain sulfur يشبه ال lincomycin بس عندة chlorine بالموقع السابع ابدال ال OH

Lincomycin: Contain pyrrolidine nitrogen Cause diarrhea Inhibit protein synthesis Contain sulfur

Chloramphenicol:  Broad spectrum The main pathway of metabolism is through 3-o glucuronidation Inactivated by chloramphenicol acetyltransferase Use for severe infections Has bitter taste

Clarithromycin: Is the 6-methyl ether analog of erythromycin Have better properties than erythromycin and less GI adverse effects Protein synthesis inhibitor يشبه ال erythromycin بس الاختلاف بالموقع السادس عندة methyl ether بينما ال erythromycin عندة OH

Azithromycin: Contain basic tertiary amine at C9 Acid stable Protein synthesis inhibitor يشبه ال erythromycin بس عندة tertiary amine بالموقع 9 بدال الكيتون

Doxycycline: Don’t have the 6-hydroxyl group Have long half life Have 5-alphahydroxyl group Stable in acids and bases يشبه ستركجر ال tetracycline بس مابيه oH بالموقع 6

New cephalsporin Cefpirome: Fourth generation cephalosporin Have quaternary ammonium group at 3 position Have potency against gram positive and gram negative bacteria

Ceftriaxone: Third generation cephalosporin Broad spectrum Have long half life given once daily Excretion in bile and urine The unique pharmacokinetics properties due to the presence of dioxotriazine ring Less active against B.fragilis