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اسئلة د.عمار https://t.me/pharma89a/1748 اسئلة د.محمد https://t.me/pharma89a/1750 اسئلة د.زينب https://t.me/pharma89a/1752 ملخص محاضرات 8 - 9 - 10 د.زينب من دفعة 88🤍 https://t.me/pharma89a/1754 عسى ان تكون ختامها مسك all the best 🤍

Lincomycin: Contain pyrrolidine nitrogen Cause diarrhea Inhibit protein synthesis Contain sulfur

Azithromycin: Contain basic tertiary amine at C9 Acid stable Protein synthesis inhibitor يشبه ال erythromycin بس عندة tertiary amine بالموقع 9 بدال الكيتون

Chloramphenicol:  Broad spectrum The main pathway of metabolism is through 3-o glucuronidation Inactivated by chloramphenicol acetyltransferase Use for severe infections Has bitter taste

Clindamycin: Contain chlorine group at position 7 More potent than lincomycin Cause diarrhea Inhibit protein synthesis Contain sulfur يشبه ال lincomycin بس عندة chlorine بالموقع السابع ابدال ال OH

Erythromycin: The amino sugar at c3 is cladinose and at c5 is desosamine Have irregular oral absorption and bitter taste Protein synthesis inhibitor

Clarithromycin: Is the 6-methyl ether analog of erythromycin Have better properties than erythromycin and less GI adverse effects Protein synthesis inhibitor يشبه ال erythromycin بس الاختلاف بالموقع السادس عندة methyl ether بينما ال erythromycin عندة OH

Gentamicin: Have strong activity against P.aeruginosa Inactivated by adenylylation and acetylation

New cephalosporin Aztreonam: It’s monobactam Have high affinity to PBP3 in gram negative bacteria only Inactive against gram positive bacteria and anaerobes Contain isobutyic acid oximinoacyl group

Ceftazidime: Third generation cephalosporin Have antipseudomnal activity Contain pyridinum group at position 3 Have beta lactamase resistant due to the presence of 2-methylproionicoxaminoacyl group