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MCQs || B21

MCQs || B21

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MCQs || B21
Which of the following best describes the concept of 'tumor heterogeneity'?
Anonymous voting

2
Which of the following is a direct consequence of the activation of hypoxia-induced factor 1α (HIF-1α) in tumor cells?
625
3
What is the significance of the Philadelphia chromosome in chronic myelogenous leukemia?
404
4
Which inherited condition is associated with a defect in DNA mismatch repair, increasing the risk for the development of cancer?
352
5
What is the role of the TP53 gene in the context of apoptosis?
330
6
What is the primary mechanism by which cancer cells achieve replicative immortality?
329
7
Which factor is activated under hypoxic conditions in tumors and leads to the transcription of VEGF genes, promoting angiogenesis?
335
8
During the process of metastasis, what is the sequence of steps that tumor cells undergo?
355
9
Which gene is primarily involved in the intrinsic pathway of apoptosis and is often found activated in follicular lymphoma, protecting tumor cells from apoptosis?
347
10
What is the clinical significance of the HER2/neu receptor in breast cancer?
387
11
Which of the following best describes the role of driver mutations in cancer?
376
12
In the context of cancer, what is the significance of the 'two-hit hypothesis' for tumor suppressor genes?
356
13
Which gene is commonly mutated in human cancers and plays a crucial role in cell cycle arrest and DNA repair?
343
14
What distinguishes oncogenes from proto-oncogenes?
367
15
Which of the following is a fundamental principle of oncogenesis?
361
16
What percentage of all human cancers is constituted by hereditary cancers?
369
17
Which enzyme family plays a crucial role in the activation of carcinogens to ultimate carcinogens within the liver?
372
18
What is the primary cause of skin cancer as identified in the study of carcinogenic agents?
375
19
Which lifestyle factor has been directly linked to a reduction in breast cancer risk according to epidemiological studies?
367
20
Which carcinogenic agent is responsible for the majority of lung cancer cases attributable to occupational exposure?
70
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