Lina Sudanses local Derma Telegram

Differentiation is A. Cells organelles increase in size. B. Movement of cell from basal layer to corneal layer with keratin formation

■1409 Local derma part 1 2022

Tuberculoid (TT) leprosy is the paucibacillary form defined clinically by: A few( less than 5 ) sharply defined red patches with raised borders that are asymmetrically distributed or a single larger hypopigmented patch less than 10 cm in diameter Loss of sweating with rough dry hairless skin in the patches Loss of sensation in lesions A few affected nerves with diminished sensation and burning or tingling sensations. Significant sensory loss 《early》 in the disease course.Affected nerves are thickened and tender on palpation.

The Paucibacillary classification encompasses : indeterminate tuberculoid   《TT》 and borderline tuberculoid leprosy.《BT》  The Multibacillary classification includes midborderline, 《BB》 borderline lepromatous 《BL》 and lepromatous leprosy 《LL》

Explanation

BL is multibacillary

Answer

leprosy: A. BL is multibacillary B. LL and TT are pucibacillary C. TT are nemrous lesions D. Nerve affeted late in TT.

■1408 Local derma part 1 2022

Pityriasis versicolor is caused by mycelial growth of fungi of the genus Malassezia. Malassezia are part of the normal skin microbiota (microorganisms found on normal skin). They are dependent on lipid for survival. Fourteen different species of malassezia have been identified. The most common species cultured from pityriasis versicolor are M globosa, M restricta and M sympodialis.

Explanation

Masezzia furfur

Answer

Lina Sudanses local Derma Telegram: 248 What is the causative organism of pitryasis versicolor A. Masezzia furfur B. T. Scolenni C. T. Rubrum D. E. folcum E. E. mentagrophytes

■1407 Local derma part 1 2022

Antacids and H2 antagonists should not be taken for 2 hours after griseofulvin because they might otherwise stop its absorption. Griseofulvin interacts with alcohol rather like disulfiram (Antabuse) and can cause severe nausea and vomiting

Half the medication is cleared from the blood stream in 10 to 20 hours; the rest is eliminated in urine and faeces. This means the medication can be taken once daily. Griseofulvin should be continued until the fungal infection has completely gone because the medication is quickly cleared from skin and hair when it is stopped. Dose regime Adults: 500 mg to 1 g daily. Children: 10: 25 mg per kg body weight per day. Tinea pedis, Tinea cruris, tinea manuum, tinea corporis etc. for 2: 6 weeks. Tinea capitis for at least 6: 8 weeks (longer for M canis). Tinea unguium for 12: 18 months until all signs of nail infection have gone.

Griseofulvin may still be preferable for tinea capitis, especially when due to Microsporum canis infection, and is generally well tolerated in children. Griseofulvin tablets are not very well absorbed from the gut. They should be taken after a meal or drink of milk as fat increases the absorption. The medication is carried into the skin by sweat and within a couple of weeks is concentrated in the outer skin layers

Griseofulvin comes from the mould, Penicillium griseofulvum. It stops fungal cells dividing (i.e. it is fungistatic) but does not kill them outright. This means treatment needs to be continued for several weeks or months. ▪︎ It is not effective against yeasts such as candida or malassezia. ▪︎Pityriasis versicolor is caused by Malassezia(microsporum) Furfur