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🤓 Доктор биологических наук, профессор 🔥 Горячие новости мировой медицины 💊 Учу разбираться в лекарствах, витаминах, БАДах Сотрудничество - [email protected] ВКонтакте: https://vk.com/public211698476 Ютуб: https://www.youtube.com/@AnchaBaranovaProf
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Nature - The in-tissue architectures of β-amyloid and tau pathology in a postmortem Alzheimer’s disease donor brain are determined, showing fibril heterogeneity is spatially organized by...
Disruption of TRPC5, a brain-expressed cation channel, causes obesity, maladaptive behavior, and postpartum depression in humans and mice. Acting on hypothalamic Pomc and oxytocin neurons, TRPC5 regulates instinctive behaviors such as feeding, arousal, social interaction, and maternal care, which are fundamental for survival.
Background The combined association of physical activity (PA) and alcohol use (AU) with long-term mortality is yet to be investigated. Methods For the current study, 12,621 participants aged ≥ 20 years were enrolled from the National Health and Nutrition Examination Survey (1999–2004). The study endpoint was all-cause mortality. Cox proportional hazards regression models were used to examine the combined effect of PA and AU on long-term mortality. Results The study population was divided into young (< 60 years, N = 8,258) and old (≥ 60 years, N = 4,363) groups. The median follow-up time was 203 months. In both young and old group, sedentary lifestyle combined with even minimal AU were associated with elevated risk of death (all P < 0.05). In young group, the integration of high volume AU with any degree of PA, including sedentary PA (HR = 2.35, 95% CI 1.24–4.44, P = 0.009), low PA (HR = 1.64, 95% CI 1.01–2.68, P = 0.047), and moderate-to-vigorous PA (HR = 1.99, 95% CI 1.03–3.84, P = 0.041), was associated with…
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