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Drug Safety evaluation in special population- Paediatrics.pdf5.49 KB
ATC Classification of drugs.pdf4.86 KB
ICH_guidelines_for_Pharmacovigilance_organization_and_objective.pdf4.77 KB
CIOMS working groups.pdf4.96 KB
Basic drug information resources.pdf6.20 KB
Pharmacovigilance handwritten notes➡️
Did you know the main differences between broad-spectrum and narrow-spectrum antibiotics?
1. Range of Activity:
📌- Broad-Spectrum Antibiotics: These antibiotics are effective against a wide variety of bacteria, including both Gram-positive and Gram-negative bacteria. They are often used when the specific bacteria causing an infection are not known.
✅- Narrow-Spectrum Antibiotics: These antibiotics are effective against a specific group of bacteria. They are used when the causative bacteria are identified, allowing for targeted treatment.
2. Impact on Microbiome:
📌- Broad-Spectrum Antibiotics: Because they target a wide range of bacteria, they can disrupt the normal microbiome, potentially leading to side effects such as antibiotic-associated diarrhea or yeast infections.
✅- Narrow-Spectrum Antibiotics: These tend to have less impact on the normal microbiome since they target specific bacteria, which can help preserve beneficial bacteria.
3. Use Cases:
📌- Broad-Spectrum Antibiotics: Often used in emergency situations or when a patient is severely ill and the specific pathogen is unknown.
✅- Narrow-Spectrum Antibiotics: Typically used when the specific bacteria have been identified through culture and sensitivity testing.
📕medscape
📕 Lippincott Pharmacology
📕dipiro pharmacotherapy
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