Pharmacist Guide
Pharmacist Guide is an Iraqi medical channel dedicated to explaining pharmacology lectures and Theraputics. Accredited by the CPD Certification Service. YouTube Link: https://www.youtube.com/@PharmacistGuide94 Mohammed Jawad Certified Trainer
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Background: No studies have reported the long-term outcomes of initiating sodium–glucose cotransporter-2 inhibitors (SGLT2is) in patients with estimated glomerular filtration rates less than 20 mL/min/1.73 m2 to predialysis. Objective: To compare the risk for dialysis, cardiovascular events, and death between SGLT2i users and nonusers in patients with type 2 diabetes (T2D) and stage 5 chronic kidney disease (CKD). Design: Target trial emulation study. Setting: Taiwan’s National Health Insurance Research Database (NHIRD). Participants: By applying sequential target trial emulation principle, 23 854 SGLT2i users and 23 892 SGLT2i nonusers were selected from the NHIRD for patients with T2D and stage 5 CKD from 1 May 2016 to 31 October 2021. Measurements: Conditional Cox proportional hazards models were used to compare the risks for dialysis, hospitalization for heart failure, acute myocardial infarction (AMI), diabetic ketoacidosis (DKA), acute kidney injury (AKI), and all-cause mortality between SGLT2i users and…