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Q/ Mention (5) mechanisms (with examples) that viruses use to escape immunity. “From 2019 finals”

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Which one of the following cells would be most effective in defence against Adult Schistosoma in the vesical plexuses?
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What do macrophages secrete that causes inflammation and sepsis:
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Cells play major role in immunity against phagocytized bacteria:
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Most important cell in immune response to helminths:
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The principal mediator of innate immunity against fungi is the:
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The principal defense mechanism against protozoa that survive within cells is :
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Which coreceptor's binding would be inhibited by this technique?
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Herpes simplex viruses are extremely successful pathogens because they have a variety of immunologic evasion mechanisms. For example, both HSV1 and 2 depress the expression of MHC class I molecules on the surface of infected cells. ⬇️

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Mycobacterium tuberculosis has the ability to survive and even replicate within the lung because of
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Patients with tuberculus granulomas that have elevated amounts of IL-2, IFN y, and TNF. The immune cell responsible for this pattern of cytokine production is the
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A patient skin tested with purified protein derivative (PPD) to determine previous exposure to mycobacterium tuberculosis and developed induration at the skin test site 24 hours later . Histologically , the reaction site would most probably show :
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#ImD #micro_L11_L12 #Immunity_to_infection

ادري هوسة صارت حرتبها الكم باللستة كل شي تريدوه تلكوه هنا

👑 MOST TESTED ASSOCIATIONS 🪽 TB → Granuloma 🪽 Influenza → Drift + Shift 🪽 African Trypanosome → VSG 🪽 Schistosoma → Disguise 🪽 Tapeworm → Hydatid cyst 🪽 Toxoplasma → Inhibits phagosome-lysosome fusion 🪽 Trypanosoma cruzi → Escapes phagosome + Cleaves IgA 🪽 Leishmania → Complement resistance + Killing resistance + Digestion resistance 🪽 Candida → Inhibits phagocytosis 🪽 Cryptococcus → Capsule 🪽 Protein A → Staphylococcus aureus 🪽 IgA protease → Neisseria + Haemophilus 🪽 Coagulase → Staphylococcus aureus 🪽 No MHC-I → NK cell 🪽 IL-4 → IgE 🪽 IL-5 → Eosinophils 🪽 IFN-γ → Activated macrophages 🪽 IL-12 → NK activation

🍄 FUNGI 🪽 Opportunistic fungi → Candida albicans → Aspergillus fumigatus → Pneumocystis jirovecii 🪽 Inhibits phagocytosis → Candida albicans 🪽 Capsule inhibits phagocytosis → Cryptococcus neoformans 🪽 Suppresses T-cell responses → Dermatophytes

🔹🪱 PARASITE EVASION 🪽 Sequestration → Tapeworm (Hydatid cyst) 🪽 Disguise → Schistosoma 🪽 Antigenic variation (VSG) → African trypanosome 🪽 Antigen shedding → Plasmodium falciparum → Schistosoma mansoni 🪽 Cleaves IgA → Trypanosoma cruzi 🪽 Inactivates complement → Leishmania 🪽 Inhibits attachment to phagocyte → Toxoplasma gondii 🪽 Inhibits phagocytosis → African trypanosome 🪽 Escape from phagosome → Trypanosoma cruzi 🪽 Resistance to killing → Leishmania 🪽 Inhibits phagosome-lysosome fusion → Toxoplasma gondii 🪽 Resistance to digestion → Leishmania (gp63) 🪽 Inhibits IL-2 & TNF → Trypanosoma cruzi 🪽 Lymphocyte activation → Trypanosomes 🪽 Lymphocyte suppression → Malaria

ذني يندرخن انتبهوا للفرق عاللي ماشرته كلهم الهم علاقة بالphagocytosis خاف تتخربطون بينهم فرقوا
ذني يندرخن انتبهوا للفرق عاللي ماشرته كلهم الهم علاقة بالphagocytosis خاف تتخربطون بينهم فرقوا

البرسايت الجبيرة تحتاج تدخل من الIgE لان الmacrophages متكدر تسوي engulfing الها

🪱 HELMINTHS (WORMS) 🔹Defense: 🪽 Th2 🪽 IgE 🪽 Eosinophils 🔹Examples: 🪽 flatworm>Schistosoma 🪽 roundworm>Ascaris 🔹Buzzwords: 🪽 IL-4 → IgE 🪽 IL-5 → Eosinophils 🪽 ADCC 🪽 High IgE + eosinophils = worm infection