LNN ACADEMY 🦠🩺💊

Upsc esic nursing officer answer key

MYASTHENIA GRAVIS An autoimmune neuromuscular junction disorder caused by antibodies against nicotinic acetylcholine receptors → leads to fatigable muscle weakness. Epidemiology ♀️ Women: 20–30 yrs ♂️ Men: 60–80 yrs 🧠 ~75% have thymic abnormalities (hyperplasia > thymoma) Key Clinical Features ✔️ Fatigability: Weakness worsens with activity, improves with rest ✔️ Commonly affected: ocular (ptosis, diplopia), facial, bulbar, neck & limb muscles ✔️ No sensory loss or autonomic symptoms ✔️ Reflexes: normal Diagnosis 🧪 AChR antibodies (1st-line) 🧪 EMG → decremental response 🧪 Ice pack test ❄️ improves ptosis 🧠 Chest CT/MRI to rule out thymoma 💊 Edrophonium test = short-lived improvement Management 1️⃣ Crisis: Plasmapheresis / IVIG + steroids 2️⃣ Chronic: Pyridostigmine (± glycopyrrolate) → add steroids → transition to azathioprine 3️⃣ Surgery: Thymectomy if thymoma or age <60 with mild-moderate disease —————————-