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Immortal time bias (ITB) is common in cohort studies and distorts the association estimates between the treated and untreated. We used data from an Italian study on COVID-19 vaccine effectiveness, with a large cohort, long follow-up, and adjustment for confounding factors, affected by ITB, with the aim to verify the real impact of the vaccination campaign by comparing the risk of all-cause death between the vaccinated population and the unvaccinated population. We aligned all subjects on a single index date and considered the “all-cause deaths” outcome to compare the survival distributions of the unvaccinated group versus various vaccination statuses. The all-cause-death hazard ratios in univariate analysis for vaccinated people with 1, 2, and 3/4 doses versus unvaccinated people were 0.88, 1.23, and 1.21, respectively. The multivariate values were 2.40, 1.98, and 0.99. Possible explanations of this trend of the hazard ratios as vaccinations increase could be a harvesting effect; a calendar-time bias, accounting…
Facci sognare Orban❗
“Siamo qui da circa 5 anni a causa di una pandemia inventata. Fanculo questi bastardi"🔥💥
Star Wars annuncia il suo nuovo modello di robot, P-3DO.😉
Gli americani parlano sempre di un ordine internazionale basato su regole, ma minacciano di ucciderti se non fai quello che ti diconoInterrogato sul caso Assange e sul futuro degli informatori, Roger Waters, musicista britannico e fondatore del gruppo Pink Floyd, ha denunciato l'ordine internazionale "basato su regole" sostenuto ma mai attuato dagli STATI UNITI.
mRNA specialist CureVac, which struggled to compete with the likes of Pfizer, Moderna and BioNTech, said it will focus on developing mRNA cancer vaccines and will cut 30% of its staff.
Studio Scientifico
⚠️ I robot di intelligenza artificiale potrebbero occupare oltre l’80% dei posti di lavoro umani nei “prossimi anni”.
На вашому тарифі доступна аналітика тільки для 5 каналів. Щоб отримати більше — оберіть інший тариф.