WILL OF MED NINJA🥷🔥.
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إذا كان لديك حلم...كن صانع نتائج لا صانع أعذار🔥⛓️ "ملخصات وملاحظات لتصبح نينجا الطب وتتقدم نحو أهدافك 💉📚🥷”
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Немає даних24 години
+37 днів
+1930 днів
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🔹️First generation: can not cross BBB.
🔹️Second generation: can not cross BBB except cefuroxime.
🔹️Third generation: cross BBB except cefuberazone.
🔹️Fourth generation: cross BBB.
Methods used for microbial control:
🔹️Sterilization Methods (التعقيم)1. Autoclaving → Surgical instruments / Surgical gowns / Cotton / Gauze 2. Tyndallisation → Food industries 3. Flaming → Sterilize loops 4. Hot Air Oven → Glassware (Test tubes / Glass bottles / Glass slides) 5. Incineration → Disposal infectious materials (Syringes / Needles) 6. Gamma Rays → Syringes / Catheters / Rubber gloves 7. Filtration → Heat-sensitive substances (Vitamins / Hormones / I.V solutions) 8. Ethylene Oxide (Gas) → Heat-sensitive substances 9. Peracetic Acid (Liquid) → Laparoscopic instruments
🔹️Disinfection Methods (التطهير)1. Pasteurization → Milk (kills pathogenic bacteria) 2. Boiling Water → Water (home use) 3. UV Light → Operating room surfaces 4. Quaternary Ammonium Compounds → Floors / Furniture / Bed rails / Equipment surfaces 5. Phenolic Compounds → Environmental disinfection 6. Chlorine (Hypochlorite) → Homes & Hospitals 7. Glutaraldehyde 2% (Cidex) → Heat-sensitive equipment (Endoscopes / Dialysis / Respirators)
🔹️Antiseptic Methods (مطهرات الجلد)1. Ethyl Alcohol (70%) → Skin antiseptic 2. Iodine Tincture (2%) → Skin antiseptic (less used) 3. Iodophors → Preoperative skin / Minor wounds 4. Hydrogen Peroxide → Deep wounds cleaning 5. Chlorhexidine → Surgical hand hygiene / Oral hygiene / ICU bathing 6. Silver Nitrate (1%) → Ophthalmia neonatorum prophylaxis ⭕️هذا الدرس مهم جداً ركزوا عليه.
Fungus includes•yeasts •molds •mushrooms
Fungi obtain soluble nutrients by secreting degradative enzymes:•Cellulases •Proteases •Nucleases
Clinical samples may be:• pus • blood •spinal fluid •sputum •tissue biopsies • skin scrapings.
Classification of pathogenic fungi1- CUTANEOUS MYCOSES 2-SUBCUTANEOUS MYCOSES 3- SYSTEMIC MYCOSES 4-OPPORTUNISTIC MYCOSES
Subcutaneous mycoses are fungal infections of:•dermis •subcutaneous tissue • bone.
Subcutaneous fungal infections are almost alwaysacquired through :•traumatic lacerations • puncturewounds
Organisms causing systemic mycoses are:•True pathogens (infect healthy individuals) •Opportunistic pathogens ( infect weakened or immunocompromised individuals)
Opportunistic mycoses Increased incidence among:•AIDS patients •Cancer patients •Post-transplant chemotherapy recipients •Users of antibiotics or immunosuppressives
Opportunistic fungal pathogens include:•Cryptococcus neoformans •Candida spp. •Aspergillus spp. •Penicillium spp.
Virus Structure•Capsid •Genetic Material (RNA or DNA) •Enzymes •Envelope (in some viruses)
Viral Capsid1) Helical structure: Ex: Rabies virus, Measles virus 2) Icosahedral structure: Ex: Rubella virus, HBV,HAV 3) Complex structures: Ex: Poxvirus, binary bacteriophages.
Viral enzymes●mRNA by RNA polymerase ●reverse transcriptase. ●Integrase ● cap-depend entendonuclease ●protease
Types of viruses genomes:• dsDNA • ssDNA • ssRNA • dsRNA • Segmented and non-segmented
Viruses are mainly classified by:1) morphology 2) nucleic acid type& mode of replication 3) host 4) the type of disease they cause.
Two main systems classify viruses:•(ICTV) system •Baltimore classification system.
Levels of classification (in order):●Order: ends in -virales ●Family: ends in -viridae ●Subfamily: ends in -virinae ●Genus: ends in -virus ●Species: usually the disease name (e.g., Measles virus)
Subviral agents●Satellites ●viroids ●prions
Virus replication has six main phases:1) Attachment. 2) Penetration (entry). 3) Uncoating. 4) Biosynthesis 5) Assembly. 6) Release.
Host cells provide viruses with:•Machinery for translating viral mRNAs •Sources of energy
Virology🔹️Viral DNA genome: 3.2 kbp – 375 kbp 🔹️Viral RNA genome: 7 – 30 kbp 🔹️Kbp = 1000 base pair 🔹️Number of known viruses: over 5000 🔹️David Baltimore: born 1938, Nobel Prize 1975 🔹️ICTV: founded late 1960s 🔹️Prion diseases incubation period: 5 – 20 years
Mycology🔹️Yeasts: size 5–8 µm
