Pulmonology online

Новая номенклатура наименований моноклональных антител Каждая крупная онкологическая конференция сопровождается большим количеством новостей по разным этапам разработки моноклональных антител к различным мишеням. Но называются они, зачастую, как-то непривычно. Волрустомиг, сувемцитуг и компания. Почему так - и где всем привычный суффикс "маб"? Неожиданно - оказалось, что в конце 2021 года экспертная группа ВОЗ выпустила обновленную номенклатуру наименований моноклональных антител, в соответствии с которой использование корня "-маб" более не рекомендовано для обозначения моноклональных антител. Вместо этого эксперты ВОЗ предлагают использовать новую классификацию с использованием четырех различных суффиксов - в зависимости от характеристик именуемой молекулы: 🔹-tug - для моноспецифических молекул с немодифицированной константной частью; 🔹-bart - для моноспецифических генетически модифицированных иммуноглобулинов ("artificial"); 🔹-ment - моноспецифические фрагментные антитела, модифицированные или нет ("fragment"); 🔹-mig - биспецифические и мультиспецифические антитела ("multi-specific immunoglobulins"). Для желающих ознакомиться с полной версией и историей классификации моноклональных антител - статья в открытом доступе.

Check your answers to this week's radiology image challenge! 1. a. Ground glass opacification and lung parechymal nodule. On the chest radiograph there is marked increased opacification within both lower zones more than can be accounted for by the breast shadows alone. On the selected HRCT image note the presence of widespread ground glass opacification (red arrow) with areas of relative sparing (yellow arrow) – mosaic attenuation pattern. In addition there are peripheral nodules most of which are ill defined and difficult to appreciate (blue arrow). 2. b. Hypersensitivity pneumonitis. The most likely diagnosis is hypersensitivity pneumonitis (extrinsic allergic alveolitis). This is an allergic lung disease caused by a variety of antigens. In this case the patient had recently started to keep birds as pets and this was the most likely source of the antigen. In the acute stage, the differential diagnosis would include respiratory bronchiolitis interstitial lung disease (not in this case as the patient is a non smoker) and alveolar proteinosis. Thanks for taking part this week! Try more case studies on the ERS Respiratory Channel: https://channel.ersnet.org/channel-52-radiology-image-challenge

It's time for this week's radiology image challenge! Today's case study: A 32-year-old female non-smoker with acute onset of shortness of breath at rest and dry cough. Arterial blood gas revealed a pO2 = 5 on room air. The patient had previously attended the emergency department with a similar episode. Image 2: Selected axial HRCT image obtained on full inspiration. 1. What is the main abnormality? a. Ground glass opacification and lung parechymal nodule b. Evidence of air trapping and interstitial septal thickening c. Lung parenchymal nodule d. Paraseptal emphysema e. Normal appearances 2. What would you consider as the most likely diagnosis? a. Alveolar proteinosis b. Hypersensitivity pneumonitis c. Sarcoidosis d. Tuberculosis e. Desquamative interstitial pneumonitis Comment your answers below and check back on Thursday to see if you are correct! In the meantime, try more case studies on the ERS Respiratory Channel: https://channel.ersnet.org/channel-52-radiology-image-challenge

Видео не для всех. 3 мужика разговаривают о eCPR (ЭКМО при реанимации) на немецком. Видео хорошо подходит для еще изучающих язык, т.к. там прекрасные субтитры. https://getinge.wistia.com/medias/xw5ndf0qis

Check your answer to this week's radiology image challenge! The answer is c. Lobar collapse. The main abnormality is the presence of right upper lobe collapse. There is associated volume loss within the right hemithorax and a dense opacity at the right hilum (red asterisk) which is narrowing the right main bronchus (blue arrow). The findings are likely due to a central bronchogenic carcinoma (dense opacity at the right hilum) which has obstructed the upper lobe bronchus. The film is an example of the reverse Golden S sign. This sign resembles a reverse S shape and is due to the contour created by the collapsed right upper lobe and hilar mass (yellow arrows). Thanks for taking part in this week's quiz! Try more case studies on the ERS Respiratory Channel: https://channel.ersnet.org/channel-52-radiology-image-challenge

Test your knowledge with the latest radiology image challenge! Case study: A 57-year-old male smoker with breathlessness and chest pain. What is the main abnormality? a. Lobar consolidation b. Post-radiotherapy change c. Lobar collapse d. Normal post-operative changes e. Pleural abnormality Comment your answer below and check back on Thursday to see if you are correct! While you wait, you can try more case studies on the ERS Respiratory Channel: https://channel.ersnet.org/channel-52-radiology-image-challenge