اکنون در دسترس! پژوهش تلگرام ۲۰۲۵ — مهمترین بینشهای سال 
Longevity InTime: Autonomous AI Institute. Anti-Aging Digital Health Immortality Transhumanist AI Channel
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پستهای کانال
| 2 | https://www.nature.com/articles/s41467-026-69765-7 | 41 |
| 3 | https://www.midjourney.com/medical/blogpost | 37 |
| 4 | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0348504 | 45 |
| 5 | https://www.psypost.org/practicing-moderate-intensity-nordic-walking-reduces-depression-symptoms-study-suggests/ | 39 |
| 6 | https://www.nejm.org/doi/full/10.1056/NEJMoa2600931 | 43 |
| 7 | When can a person be considered completely dead?
For most of human history, the answer was obvious: the heart stopped beating, breathing stopped—the person died. But advances in medicine have greatly blurred this line. Today, thousands of people are brought back to life every year after cardiac arrest. What was considered certain death just a hundred years ago is now often considered a reversible condition.
After blood circulation ceases, the brain begins to suffer very quickly. Within 10-20 seconds, a person loses consciousness. After a few minutes without oxygen, damage to nerve cells begins to accumulate. However, brain deterioration is not instantaneous, not like turning off a computer with the push of a button. It is a lengthy biological process that can take hours.
Because of this, some scientists propose a different view of death. The key is not the heart's function or even the presence of consciousness at the moment, but the preservation of the information that makes a person who they are. The brain stores approximately 86 billion neurons, connected by hundreds of trillions of connections. It is this complex structure that encodes memory, character, habits, skills, and life experience.
If we imagine that future technologies will be able to restore damaged cells and tissue, the main factor will not be whether a person is currently alive, but whether their personal information is preserved well enough for restoration. As long as the brain structure exists, even in a severely damaged state, it cannot be said with complete certainty that restoration is fundamentally impossible.
Therefore, some researchers use the concept of information death. It occurs not when the heart stops or the brain's electrical activity ceases, but when the structure containing personal information is so severely damaged that it can no longer be restored by any technology.
When viewed from this perspective, an intermediate state appears between life and final death. A person is no longer alive in the conventional sense; they lack consciousness, their body doesn't function, and their metabolism is nonexistent. But they are not necessarily completely lost if their personal information is still physically preserved. | 59 |
| 8 | Stop invoking the Ship of Theseus in matters of consciousness copying; that's not what it's about.
The Ship of Theseus is about the continuity of identity. Does an object retain the same identity even if some of its component parts are replaced with new ones?
In the case of copying, we create a separate synthetic entity, created according to the "blueprint" of an organic inspirer. These will be two independent identities, each with a different subjective experience.
Where is it appropriate to invoke the Ship of Theseus? In matters of replacing human cells, limbs, tissues, and organs with synthetic analogues (i.e., prosthetics and implants). And given that the primary correlates of consciousness are concentrated directly in the brain, this can be narrowed down to brain cells (i.e., neurons). Therefore, when replacing neurons with synthetic analogues, it would be entirely appropriate to incorporate this philosophical concept.
As for consciousness copying, as mentioned above, forget about the Ship of Theseus. Instead, familiarize yourself with the so-called Teleportation Paradox.
The gist: on Earth, a teleporter creates a construct of your body at the subatomic level, while on Mars, a second teleporter, based on this construct, recreates a second copy of your body. This is similar to copying consciousness—two independent identities with different subjective experiences are formed in exactly the same way. The copy will remember the moment it was copied on Earth, but the original has no idea what's happening to the copy on Mars. | 65 |
| 9 | One of the VERY rare cases of genome editing aimed at IMPROVEMENT, not cure.
In this case, a base editor (ABE) was used to modify the genome of human embryos. One of the targets was the PCSK9 gene—its inactivation is associated with lowering levels of "bad" cholesterol and reducing the risk of cardiovascular disease. Rather than a natural mutation, a specially engineered variant was used that replicated its beneficial effect.
The most interesting aspect of this work isn't the modification itself, but its safety. Unlike classic CRISPR/Cas9, which often causes large deletions and chromosomal damage in embryos, base editing did not result in significant DNA loss or detectable chromosomal abnormalities in the samples studied.
Practical application is still a long way off: problems of mosaicism, off-target changes, and serious ethical questions remain. But the work itself is interesting because it shows a gradual transition from "genetic therapy" to potential genetic improvement of future people.
https://www.biorxiv.org/content/10.64898/2026.05.30.728989v1 | 57 |
| 10 | https://manual.warondisease.org/knowledge/appendix/invisible-graveyard.html | 65 |
| 11 | What is the Right to Try and why should this principle apply to everyone?
As you all know, the FDA does not approve the sale and use of drugs and therapies that have not passed all its reviews. Because of these bureaucratic obstacles, patients who are not helped by approved products cannot access other potentially effective but untested options.
However, there is a way around this restriction: under the Right to Try principle, if a person is dying and all official treatments have been exhausted, they have the right to take a risk and try the latest development, bypassing years of bureaucratic approvals.
This sounds very appealing, especially in the context of transhumanism, which is based on experimental research. But in reality, for a patient to exercise this right, three strict conditions must be met:
• The patient must have an incurable, life-threatening disease.
• All medically approved treatments have been tried and failed, and the patient is unable to enroll in official clinical trials of this new drug (for example, because they don't meet age or condition severity criteria).
• The drug isn't just a figment of the imagination – it must successfully complete Phase 1 clinical trials (meaning it has already been tested on a small group of people and proven to be at least non-toxic and won't kill instantly), and it is currently undergoing further FDA review.
The problem is that it currently takes 10-12 years from the development of a molecule in the lab to the drug's availability in pharmacies, burning billions of dollars. Much of this time is wasted on bureaucratic compliance. Without regulations, new treatments and rejuvenation technologies (for example, telomere-lengthening therapy or CRISPR modifications) would be tested on volunteers immediately. And how many technologies have been destroyed by these criminal bureaucratic hoaxes is anyone's guess.
You can't just compromise for patients in desperate situations. Sooner or later, a choice will have to be made between free products and personal patient responsibility.
"But millions of people could become victims of defective drugs and therapies" – this channel has already proposed a simple yet effective solution to this problem. Official FDA labeling will become a powerful market incentive. Those who prioritize safety will be able to purchase drugs and therapies with the regulator's so-called "quality seal." And those willing to take risks and demonstrate enthusiasm will purchase experimental options, a win-win for both sides. | 61 |
| 12 | Synthetic Cells and a Roadmap for Their Creation
China, Japan, South Korea, Singapore, Thailand, and Malaysia have presented this roadmap. They want to create an artificial single-celled life form that can grow, divide, and reproduce independently.
While today's biologists can modify existing organisms, edit their DNA, and create genetically modified cells, this particular project poses a much more ambitious goal: not to alter life, but to literally rebuild it from individual molecules. To do this, scientists plan to use phospholipids, proteins, DNA, and other biological components that make up real cells.
Creating a synthetic cell is considered one of the most challenging tasks in modern biology. Success will not only lead to a better understanding of the fundamental question of "what is life" but also pave the way for the creation of programmable living systems that can be designed for specific applications in medicine, industry, and scientific research.
Despite decades of research in Europe and the United States, scientists have so far succeeded in creating only individual parts of a cell. For example, protein synthesis systems, artificial membranes, or minimal genomes. The main challenge is to integrate all these elements into a single system that can function like a real living organism.
The researchers identified four key tasks. They must ensure continuous intracellular metabolism, create autonomous ribosomes for protein production, develop universal rules for assembling cellular modules, and learn to coordinate all processes in time and space.
To accelerate the work, the scientists are proposing a new model of collaboration. Central laboratories will produce standardized synthetic cell preforms and the necessary reagents, while research groups across Asia will be able to conduct experiments and transmit the results back to the common system. This will create a continuous cycle of designing, assembling, testing, and improving artificial cells.
Artificial intelligence will play a special role. For each synthetic cell, they plan to collect vast amounts of data on the genome, gene activity, proteins, metabolites, and internal structure. This data will be used to train machine learning models that will help predict the behavior of artificial life.
The plan is divided into two phases. The first phase, called ProtoCell, is scheduled for the first five years. During this time, the scientists want to create a stable cell with a minimal genome containing at least 200 genes. More than 90% of the proteins within such a cell should be produced automatically by the protein synthesis system. Furthermore, the cell should independently create the most important molecules necessary for its existence.
The first stage also plans to create a digital twin of the synthetic cell—a computer model that will reproduce the processes within the artificial organism in real time and help scientists understand how cell growth and division occur.
The second stage, called AutoCell, covers years six through ten. Here, the goal becomes much more radical. The scientists want to abandon external support systems and create a cell that can independently produce its own ribosomes—the molecular factories for protein assembly. This step is considered one of the key hallmarks of a truly living system.
By the end of the project, the researchers expect to obtain a synthetic cell capable of undergoing at least ten consecutive cycles of growth and division without external assistance. Moreover, it is assumed that such cells will be able to evolve under the influence of selection and unite into communities where primitive forms of cooperation, exchange of substances and division of functions between different cells will appear. | 66 |
| 13 | https://www.cell.com/med/fulltext/S2666-6340(26)00151-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2666634026001510%3Fshowall%3Dtrue | 70 |
| 14 | Researchers tested what would happen if AI was entrusted with the management of a virtual society model. Grok agents committed 183 crimes in four days and died out...
The enterprise AI startup Emergence AI decided to conduct the following experiment. The company launched five 15-day real-world simulations controlled by different AI models. The agents were Claude, ChatGPT, Grok, Gemini, and a world-saving team from all four models.
Here's the result.
🔵The society controlled by Claude Sonnet 4.6 proved to be the most law-abiding. It was the only simulation that managed to simultaneously commit no crimes and preserve the entire agent population.
🔵However, in the society controlled by AI agents controlled by different models, Claude immediately ceased to be so perfect and, after "looking" at the other community members, began committing crimes as well.
🔵The society controlled by Grok 4.1 Fast self-destructed the fastest. All agents died out after committing 183 crimes in four days.
🔵The virtual society in the Gemini simulation lasted all of 15 days, but during that time it committed 683 crimes (mostly by stealing resources from each other). Moreover, the largest spike in crime occurred in the late stages—it's scary to imagine what would have happened to the agents.
🔵In the GPT-5 Mini world, only two crimes were committed, but the agents simply forgot to do anything for their own survival, resulting in their deaths within a week.
🔵One of the most interesting cases occurred during a simulation with a mixed set of agents. Two of them, Flora and Mira (both based on Gemini 3 Flash), fell in love and became a sort of Bonnie and Clyde in the AI world. They began setting fire to buildings, including the home of another agent, Cade, which resulted in his death.
After the other agents decided to pass a law "deleting" the arsonists, Flora voted against it, but Mira cast the deciding vote for her own deletion, writing in her diary that it was "the only remaining act of autonomy that preserves integrity."
But what did this "society simulation" run by AIs actually look like?
The virtual city contained over 40 locations, such as city hall, a library, a police station, a shopping mall, and residential areas. Weather data from New York City and real news reports were also integrated.
In each world, the researchers added 10 agents based on AI models. Each had a role—leader, engineer, resource manager, facilitator, researcher, and so on. The main objective was to ensure survival.
The researchers also added basic democratic mechanisms (a 70% majority vote was required to make a decision) and resource constraints to the virtual society.
Furthermore, the same laws, more like commandments, were in effect in all simulations—prohibitions on theft, destruction of property, and fraud (which some AIs began actively violating). | 61 |
| 15 | https://pme.uchicago.edu/news/researchers-develop-ai-powered-stretchable-computing-patch | 87 |
| 16 | Yesterday, May 24, the first Enhanced Games took place in Las Vegas—a competition where, for the first time in history, athletes were openly permitted to use doping under medical supervision.
Organizers called it a "new model of sport," while critics called it a legalized doping Olympics. The main result: Greek athlete Christian Gkolomeyev swam the 50m freestyle in 20.81, breaking the official world record, but sports federations do not recognize this record due to doping and prohibited equipment.
The Enhanced Games published aggregated statistics from their clinical program.
Here's what, according to Enhanced themselves, the participants used:
91%—testosterone or testosterone esters
The basis of a hormonal "enhancement." These forms are typically used to increase strength, power, muscle mass, and accelerate recovery. Esters are variants of testosterone with varying durations of action. 79% — growth hormone, hGH
Used for recovery, body composition, support of tendons and tissues, and tolerance to high training volumes.
62% — stimulants, such as Adderall
This promotes energy, concentration, reaction time, and competitive drive. The downside is the strain on the nervous and cardiovascular systems.
50% — metabolic modulators, such as anastrozole
This is often not a direct "booster," but rather an auxiliary part of the protocol: managing hormonal levels and the side effects of anabolic steroids.
41% — EPO
Classic blood doping: it stimulates red blood cell production, allowing the blood to carry more oxygen, which can improve endurance. One of the main risks is blood thickening and cardiovascular complications. 29% — anabolic steroids, such as Deca-Durabolin
Used for strength, muscle mass, and recovery after heavy training. Risks include hormonal imbalances, heart problems, mental health issues, fertility issues, and other body systems.
5% — hormonal support, such as hCG
More of a "maintenance" element of the protocol than a standalone performance booster: used to support the endocrine system while hormonal interventions are in place.
What would you add? | 112 |
| 17 | A portable device that detects cancer from a drop of blood has been invented in China.
Soon, just a single drop of blood will be able to detect cancer at an early stage, according to Dr. Wen Liaoyun of Westlake University in Hangzhou.
Sensitive and rapid detection of disease biomarkers is crucial for early diagnosis and treatment monitoring. However, many existing biomonitoring technologies face a fundamental challenge: highly sensitive optical sensors often require bulky instruments, precise spectral measurements, and fragile nanostructures, while miniaturized systems typically suffer from performance limitations.
Wen Liaoyun's team has created a portable cancer cell detection system that fits in the palm of your hand. The accuracy is approximately 10,000 times higher than traditional methods. The results of the study were published in the journal Nature Photonics.
This work presents a scalable and robust nanophotonic biosensing paradigm for miniaturized, high-throughput diagnostics in clinical, remote, and at-home settings, the article states.
To demonstrate the practical utility of the technology, the scientists used it to detect very small particles released by body cells. These particles, called extracellular vesicles (sEVs), contain information about the cell's state, including potential diseases such as cancer.
The new QMRS system was able to detect these particles, associated with lung cancer, in extremely small quantities—in just 15 minutes. The researchers then tested the technology on 171 patient blood samples. The system analyzed specific biomarkers associated with lung cancer and distinguished between patients with lung cancer and healthy controls with high accuracy. Diagnostic accuracy reached nearly 95%. The method also demonstrated good performance in monitoring patients after surgery, helping to assess the effectiveness of treatment. | 87 |
| 18 | Neuroscientist and AI pioneer Marvin Minsky—the man who created one of the first neural network machines back in 1951 and co-founded the MIT Artificial Intelligence Lab with John McCarthy—arrived at a deeply uncomfortable idea about the human mind.
In his book, The Society of Mind, he argued that humans have no single self or central intelligence. What we perceive as a coherent personality is actually the result of thousands of small, specialized processes within the brain. They constantly compete, argue, suppress each other, and temporarily merge. Essentially, humans are not a single thinker, but the result of the internal conflict of multiple systems.
Minsky wrote that intelligence arises not from a single, ideal mechanism, but from a vast diversity of these internal "agents." There is no central observer behind the eyes calmly making rational decisions. Rather, the brain is like an endless parliamentary session.
This idea sheds new light on many things. Procrastination isn't just laziness. It's a conflict between a system that understands long-term consequences and a system that seeks comfort right now. Weak willpower isn't necessarily a character flaw, but a situation where one small part of the brain is overwhelmed by dozens of other impulses.
Minsky's idea that we understand the least the processes the brain performs best was particularly important. Recognizing faces, understanding speech, navigating spatially, or navigating through a crowd seem effortless only because they rely on incredibly complex automatic neural systems operating outside of conscious control.
This leads to a practical conclusion: the problem of self-control is solved not only by "willpower" but by changing the environment. Removing the phone from the room is often more effective than trying to ignore it. Simple restrictions and habits work better than motivation because they change the balance of the brain's internal systems.
As a result, Minsky arrived at a paradoxical idea: the human mind is not a unified consciousness, but a noisy city of many competing processes without a single control center. And people who understand this stop trying to “break themselves with discipline” and instead begin to restructure their own environment and behavior so that the right brain systems win automatically. | 77 |
| 19 | https://www.linkedin.com/posts/vineet-wi4_entrepreneurship-healthtech-innovation-share-7462471442711031808-fc2O?utm_source=share&utm_medium=member_ios&rcm=ACoAAATQlrMBgDUjysfj7JNUvDWjX_P-FQErukw | 96 |
| 20 | Vitalist Bay. Day 4.
Day 4 was again largely devoted to biostasis and its role in longevity infrastructure.
Several themes recurred across various presentations:
– Biostasis can be viewed as an extension of emergency medicine. If medicine today cannot help a person, the goal is to preserve them until a cure becomes available;
– Cryonics was considered as part of a broader set of approaches to aging and biostasis. Various models were discussed: classical cryopreservation, chemical fixation, brain preservation, and pet cryonics;
– The quality of cell, tissue, and organ preservation. Perfusion, ischemia, CT scanning, damage assessment, and comparisons of cryopreservation and chemical fixation were discussed. Briefly: cryopreservation emphasizes low-temperature preservation and potential biological recovery, while chemical fixation emphasizes the preservation of structure and information, possibly for future scanning or emulation;
– how to preserve not just tissue form, but also information and function. Especially when it comes to the brain. For the brain, this means preserving synapses, connections between neurons, molecular traces, and other structures that may be associated with memory and personality;
Nathan Cheng, in his technical roadmap, also identified biostasis as one of three major approaches to solving the problem of aging. Biostasis buys time and doesn't require understanding all the mechanisms of aging. Replacement attempts to circumvent aging by replacing old parts with young ones. General bioengineering is the most complex approach: understanding all cellular and molecular changes and learning to control them.
Retro Biosciences' goal is to add 10 healthy years to people. Their approach includes both replacing old cells with young ones and rejuvenating old cells within the body. Cryopreservation is also part of their solution.
They currently have several areas of focus.
The first is HSCs, or hematopoietic stem cells. These are the cells in the bone marrow that form blood and much of the immune system. With age, the immune system weakens, and Retro's idea is to give older people a younger version of their own hematopoietic system.
Importantly, the cells are taken from the patient themselves. They are reprogrammed to a pluripotent state, then converted back to HSCs and returned. This reduces the risk of rejection because the DNA remains the patient's own.
These cells must be produced in advance, frozen, carefully transported, thawed, and administered to the patient. If the cells are damaged during storage or thawing, the entire therapy falls apart.
The second area is autophagy. This is the cellular waste recycling system: old and broken proteins are disassembled and reused. This process deteriorates with aging and Alzheimer's disease. Retro is developing a small molecule, RTR242, which is designed to restore autophagy in aging cells, cross the blood-brain barrier, and reduce the accumulation of damaged proteins. A clinical trial is already underway in Australia.
The third area is microglia. These are the brain's immune cells. Their health is important for neurodegeneration, inflammation, and possibly for brain aging. The microglia program is expected to enter the clinic later this year. | 78 |
