Mutflash - Medizinische Argumentationen und Studiensammlungen

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Die EU wird am Dienstag einen Vertrag unterzeichnen, um über 40 Millionen Dosen eines vorbeugenden Vogelgrippe-Impfstoffs für 15 Länder zu sichern, wobei die…

Eine Krebsmittel-Studie des Mainzer Unternehmens wird nach Todesfällen teilweise gestoppt. Dass Patienten während klinischer Studien sterben, ist normal – so zynisch das klingt. Was wirklich irritiert, ist die Reaktion von Biontech. Statt aufzuklären, verklausuliert man.

Der ZDF-Polittalk - "maybrit illner" - donnerstags 22:15 Uhr im ZDF | Hier finden Sie alle Infos zu Themen, Gästen, der Moderatorin sowie Hinweise zu Kartenbestellmöglichkeiten und Kontaktadressen.

Background Small hepatocyte-like progenitor cells (SHPCs) appear to form transient clusters in rat livers treated with retrorsine (Ret) and 70% partial hepatectomy (PH). We previously reported that the expansion of SHPCs was amplified in Ret/PH-treated rat livers transplanted with Thy1+ cells derived from d-galactosamine-treated injured livers. Extracellular vesicles (EVs) produced by hepatic Thy1+ donor cells activated SHPCs via interleukin (IL)-17 receptor B signaling. As bone marrow-derived mesenchymal cells (BM-MCs) also express Thy1, we aimed to determine whether BM-MCs could also promote the growth of SHPCs. Methods BM-MCs were isolated from dipeptidyl-peptidase IV (DPPIV)-positive rats. BM-MCs or BM-MC-derived EVs were administered to DPPIV-negative Ret/PH rat livers, and the growth and the characteristics of SHPC clusters were evaluated 14 days post-treatment. miRNA microarrays and cytokine arrays examined soluble factors within EVs. Small hepatocytes (SHs) isolated from an adult rat liver were used to…