Pharmacology

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Correct Answer - D Ans. is 'd' i.e., Shows cross reactivity with other penicillins Aztreonam It belongs to monobactams group of 13-lactam antibiotics. It is active against gram negative organisms including pseudomonas, but has no activity against gram positive organisms or anaerobes fi-lactam antibiotic with aminoglycosides spectrum. It is the only fi-lactam antibiotic that lack cross-reactivity with other P-lactam antibiotics, permiting its used in patients allergic to penicillins or cephalosporins. @pharma_vid

Correct Answer - B Answer: B - Neuro-endopeptidase inhibitor Sacubitril,a prodrug inhibiting neuro-endopeptidase enzyme Activated to Sacubitril, Inhibiting enzyme neprilysin (Neutral endopeptidases) Combination drug used in heart failure patients Usually combined with ACE inhibitors like valsartan in ratio of 1:1 @pharma_vid

Correct Answer - C Ans. C. Primaquine Gametocidal - Acts on gametocytes For all species: Primaquine, artimisinins For P. vivax: Chloroquine, quinine @pharma_vid

Correct Answer - B Ans. B. Area Under Curve decreased by 35% [Ref Kucers: the use of antibiotics 6th edn by M Lindsay Grayson p.1598] Co administration of ritonavir with rifampicin: Recommendation is to use the combination with caution. Area under curve decreased by 35% There is no change in rifampicin concentration It is recommended to monitor the antiretroviral activity of ritonavir @pharma_vid

Correct Answer - C Ans. is 'c' i.e., Finasteride @pharma_vid