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Gi doctor with interests in endoscopy, gut health, liver & medicine in general.
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5 337
Microangiopathic Hemolytic Anemia vs. Thrombotic Microangiopathy
Not all MAHA = TMA
MAHA =
Coombs - intravasc hemolytic anemia
⬆️LDH,⬇️hapto,⬆️bili
Schistocytes
[bad valve]
TMA = MAHA+microvascular thrombosis->⬇️platelets
DDx TMAs
DIC:
⬆️PT/PTT, ⬇️fibrinogen
TTP:
PT/PTT WNL, ⬆️fibrinogen
ADAMT13<1% (inherited ⬇️/autoimmune)
AMS
AKI is rare!
Rx = PLEX
HUS:
AKI
Bloody diarrhea
Shiga toxin
ADAMTS13>10%
Rx = supportive
aHUS:
AKI
No diarrhea
ADAMTS13>10%
Complement (Ab to CFH or I)
Rx = Eculizumab
5 337
+1Effectiveness of PPI treatment in EoE :
✅ symptoms resolution
✅ histological remission
⬇️ complications
⬇️ strictures
