GiT Updates and More

Local complications of acute pancreatitis

Microangiopathic Hemolytic Anemia vs. Thrombotic Microangiopathy Not all MAHA = TMA MAHA = Coombs - intravasc hemolytic anemia ⬆️LDH,⬇️hapto,⬆️bili Schistocytes [bad valve] TMA = MAHA+microvascular thrombosis->⬇️platelets DDx TMAs DIC: ⬆️PT/PTT, ⬇️fibrinogen TTP: PT/PTT WNL, ⬆️fibrinogen ADAMT13<1% (inherited ⬇️/autoimmune) AMS AKI is rare! Rx = PLEX HUS: AKI Bloody diarrhea Shiga toxin ADAMTS13>10% Rx = supportive aHUS: AKI No diarrhea ADAMTS13>10% Complement (Ab to CFH or I) Rx = Eculizumab

Amazing algorithm for Conjugated hyperbilirubinemia

Conjugated hyperbilirubinemia

Effectiveness of PPI treatment in EoE : ✅ symptoms resolution ✅ histological remission ⬇️ complications ⬇️ strictures

Mechanisms of kidney protection in response to SGLT2 inhibition