Dr.5th🦷🎓

Mumps symptoms 25% of cases - unilateral salivary gland swelling, or bilateral with a time delay 95% cases - the parotid gland only 10% of cases - the bilateral submandibular and sublingual glands with the parotid Occurs in children between the ages of 4 and 6 years Rarely in adults - the symptoms are slightly worse Incubation period is two to three weeks Symptoms appear 2-3 weeks after the patient has been infected

How mumps can be spread Sneezing or coughing Using the same cutlery and plates as an infected person Sharing food and drink with someone who is infected Kissing

Transmission of mumps virus Travels from respiratory tract to salivary glands and reproduces, causing the glands to swell

Part 2 Mumps (Epidemic Parotitis) Acute viral infection caused by paramyxovirus

Agents associated with Allergic Sialadenitis Ethambutol Heavy metals Iodine compounds Isoproterenol Phenobarbital Phenothiazine Sulfisoxazole

Allergic Sialadenitis Enlargement of the salivary glands associated with exposures to various pharmaceutical agents and allergens

Internal Radiation-Induced Pathology Radioactive iodine (RAI) treatment in cases of papillary and follicular thyroid carcinomas following thyroidectomy, leading to radiation exposure of the salivary parenchyma

Sequelae of radiation-induced salivary gland damage Candidiasis Microbial infections Plaque retention Gingivitis New and recurrent dental caries Difficulty in speaking and tasting Mucosal pain

Clinical presentation of radiation-induced salivary gland damage Symptoms of oral dryness and thick, viscous saliva (xerostomia) starting in the second week Burning sensation of the tongue Difficulty in wearing oral prostheses Increased thirst Oral mucositis (erythema and ulceration) Salivary gland function is nearly absent six to seven weeks post-radiotherapy Hypofunction remains for up to two years post-radiotherapy

Apoptosis and impaired blood flow Mechanisms of salivary gland damage from radiation

External Beam Radiation-Induced Pathology Permanent salivary gland damage after only 24-26 Gy of radiation therapy

Treatment of Cheilitis Glandularis 1. Elimination of potential predisposing factors 2. Use of lip balms, emollients, and sunscreens 3. Topical, intralesional or systemic steroids 4. Anticholinergics, systemic antihistamines, antibiotics 5. Refractory cases may require surgical intervention such as cryosurgery, vermillionectomy

Differential diagnosis of Cheilitis Glandularis Multiple mucocele Chronic sialadenitis of the minor salivary glands Factitious cheilitis Orofacial granulomatosis Actinic cheilitis

Cheilitis Glandularis is considered a premalignant lesion due to the risk of developing squamous cell carcinoma

Cheilitis Glandularis is more common in middle-aged and elderly men

Predisposing factors for Cheilitis Glandularis Poor oral hygiene Chronic exposure to sunlight (UV rays) and wind Smoking Immunocompromised state

Cheilitis Glandularis primarily affects the lower lip

Clinical features of Cheilitis Glandularis Superficial ulceration Painless crusting Swelling Induration of the lip Mucinous exudate at the dilated ductal openings

Cheilitis Glandularis Chronic inflammatory disorder affecting the minor salivary glands and their ducts

Treatment of NS Self-limiting within 3-12 weeks, use analgesics and antiseptic mouthwash, surgical intervention typically not required