Pharmacology. 48

#Lab_of_Pharma مهمة جدا ● the drugs that control MES seizure are effective against Tonic-clonic & Partial seizure ● the drugs that control PTZ seizure are effective against absence seizure

#Lab_of_Pharma Phenobarbital & Trimethadone are effective against PTZ seizure

#Lab_of_Pharma Electrical induced convulsion by = MES (maximal electro-shock) ● only Phenytoin is effective against Electrical induced epilepsy

#Lab_of_Pharma chemical to induce convulsion = PTZ (pentylenetetrazol)

Calculation of analgesic activity #Lab_of_Pharma

Intra peritoneal injection of 1% 0.2ml of acetic acid

#Lab_of_Pharma most common pain method in analgesics experiment = Chemical method (by acetic acid)

#Lab_of_Pharma Ach produce little or no diaphragm contraction = b/c rapidly metabolized and Nm receptors are deep

#Lab_of_Pharma Drug of Biphasic effect = Adrenaline

#Lab_of_Pharma in Dog-blood pressure experiment = - dog is anaesthetised by intraperitoneal urethane - BP recorded by arterial canula - BP measured by Washington recorder - drug given IV - Thrombosis prevented by Heaprin

#Lab_of_Pharma Rank of potency of adrenergic agonists = isoprenaline > adrenaline > Noradrenaline

Receptors = B1, M2, H2

#Lab_of_Pharma in isolated frog heart = 1 cm of ascending aorta should be left and perfusion pressure = 40 mmHg

#Lab_of_Pharma Receptors of guinea pig ileum = cholinergic = M3 adrenergic = alfa 1 & Beta 1 5-HT1-7 H1 Receptor

Dosage Calculation #Lab_of_Pharma

#Lab_of_Pharma any substance in which drug is diluted and administered = Vehicle should be inert + non toxic

#Lab_of_Pharma Commenest rout of administration in animal = Intraperitoneal

#Lab_of_Pharma NaCl = maintains iso-osmolarity and isotonocity of solution KCl = Maintains ionic balance CaCl = Contractility MgCl2 + MgSO4 = reduce spontaneous activity NaHCO3 = provide alkaline PH Glucose = Energy

#Lab_of_Pharma Solutions should be iso-osmolar and Isotonic

#Lab_of_Pharma Isolated tissue shoud be taken from = (Freshly killed animals + gently handling)