Pathology - Malek

A 60-year-old man presented with pallor, and petechial bleeding for two-month duration. Physical examination revealed a huge splenomegaly with no lymphadenopathy. The blood film showed pancytopenia with tear-drop red cells and leukoerythroblastic blood film. The most likely diagnosis is:

ملخص افكار الاسئلة لوكيميا بطفل الجواب ALL الا اذا ذكرلك شي يمشي ويه ال AML لان نسبة ال ALL بالاطفال هي ٨٠% لوكيميا بشخص كبير بالعمر هاي CML الا اذا ذكرلك شي يدل على CLL يعني ماركر خاص بيها او شوف شنو

The laboratory investigations of a 72-year-old woman revealed: Hb 16.7 g/dL, normal platelet and WBC counts, Positive JAK2 mutation with low serum erythropoietin. Physical examination revealed mild splenomegaly with no lymphadenopathy. The most likely diagnosis is: A. Polycythemia vera. B. Chronic myeloid leukemia. C. Essential thrombocythemia. D. Primary myelofibrosis. E. Acute myeloblastic leukemia.

A 60-year-old man presented with pallor, and petechial bleeding for two-month duration. Physical examination revealed a huge splenomegaly with no lymphadenopathy. The blood film showed pancytopenia with tear-drop red cells and leukoerythroblastic blood film. The most likely diagnosis is: A. Chronic myeloid leukemia. B. Essential thrombocythemia. C. Primary myelofibrosis.

A 4-year-old child presented with fever, pallor, and petechial bleeding for one-week duration. Physical examination revealed cervical and axillary lymphadenopathy with splenomegaly. The most likely diagnosis is: A. Acute lymphoblastic leukemia. B. Acute myeloblastic leukemia. C. Chronic myeloid leukemia. D. Chronic lymphocytic leukemia.

رمضان كريم 🤲❤️ والله يوفقكم للطاعات ويتقبل ويسهل عليكم امتحاناتكم ودراستكم ضفت فديوات وملاحظات مدتهن ربع ساعة بخصوص RBC و Wbc وذني هن الملزمتين 👇 وحنزل وراهن كيسات مال WBC ممكن تجي

ب ٨ انزللكم فديو ١٩ دقيقة بي مراجعة سريعة لكم فكرة بالكارديو خاف الزوم ياخذ وقتكم وعدكم دراسة اي استفسار دزولي @mapatho

ملاحظات الbreast : Immune cells in infection:1_ in acute infection (neutrophil) 2- in betwwen macrophage 3- in chronic infection (granuloma) —lymphocyte How to differentiate Btw TB and sarcoidosis? Tb— caseatig grauloma sarcoidosis— non caseating granuloma Mammary Duct Ectasia = can be found ( plasm cell) Adenosis: Refers to enlargement of the lobules and/or formation of new lobules, It could be a physiological process which occurs during pregnancy and reproductive life Relationship of the various patterns of Fibrocystic Changes to Carcinoma:  Minimal or no increased risk of breast carcinoma: Fibrosis, Cystic changes, Apocrine Metaplasia, Slightly increased risk (1.5-2 times): without atypia Significantly increased risk (5 times): Atypical Hyperplasia Fibroadenoma 1-This is the most common benign tumor of the female 2-Areas resembling fibroadenoma sometimes occur in Fibrocystic Changes (Fibroadenomatosis). 3-young femal 4-composed of both fibrous and glandular tissue . Fibrocystic Changes are of clinical significance:  Some variants may clinically mimic carcinoma.  They may coexist with carcinoma.  They may predispose to the development of carcinoma. inflamm cell +liqifactive fat necrosis= Traumatic Fat Necrosis Galactocele This is a cystic dilatation of a duct occurring during lactation and presenting as a tender mass. It results from obstruction of the lactiferous duct, poliferation of gladular tissue= Adenomas Intraductal Papilloma=bloody nipple discharge without mass what is feature of malgancy in cytopathology? encapsulation, large dimensions, remarkable nuclear anaplasia, and abnormal mitosis. FNA— rapid/easy/cheape/ no local ansthesia/ no(pain - bleeding-hematoma) core needle biobsy — accurate / diagnosis/use local ansthesia/ had ( pain - nematoma- bleeding) BRCA: supprassion gene mcq/ what is type of cell arrangment in lobular carcinoma? A/ Indian file Mucinous ( Colloid Carcinoma )= good prognosis Medullary Carcinoma • immune reaction so higher presence of leukocyte • very large tumer • good prognosis due to lymphocyite infilltration Papillary Carcinoma=Resemble to inraductal papillom but it has feature of malig. and some time we cant distinguish BTW them Tubular Carcinoma=good prgnosis تشبه الtubule Paget’s Disease of the Nipple=nipple discharge +skin eczma +ductal carcinoma with presence of paget cell what is 3 features of Dx grage? Tubular Differentiation; B. Nuclear Pleomorphis; and C. Mitotic Activity Grade1 best than Grade3 الافضل هو grade1 انتبهو

بالليل نتناقش بالكارديو شوية واي سوال عدكم اني حاضر هاي اهم الاشياء ماعدا الهيماتو نحجي عنه بعدين

ملزمة ال ENT مع التاشيرات ( نفس الفديوات )

أمور مهمة من ملاحظات طلاب العام و أول العام + الفايروسات ويه المرض مهمة

• Wegner's granulomatosis + TB • Sinonasal papilloma + HPV • nasopharyngeal carcinoma + EBV • Acute epiglottitis + H. Influenzae B • Juvenile laryngeal papillomatosis + HPV 6&11 (not J. L. papilloma) • Adult laryngeal papilloma + HPV 6&11 • Invasive carcinoma of larynx + HPV (IN LATE STAGES ONLY) * Nasopharyngeal carcinoma → can damage trigeminal n. ** TB in sinuses is isolated ** TB in Larynx is with active pulmonary disease * Most common cancer in external ear and skin → basal cell carcinoma * Most common form of salivary gland–type tumor of the larynx → adenoid cystic carcinoma (MCQ) * Most common microscopic type of laryneal carcinoma→ squamous cell carcinoma (MCQ) * Laryngeal carcinoma + P53 gene mutation