《PHARMACY》

خل اضحكم يوم بالجامعة مدنكة عالايباد سمعت طكطكه تمشي عالارضية شون رجلين الفرس(الحصان ) گلت بس هاي بقت يطبلنه فرس طايش طلعت بنيه تمشي لابسة كعب😂 من تمشن بنات لاذبن حيلچن عالكعب شيلن رجليچن😂 ماصايرة ترا

Erythromycin A: (commercial product) having a hydroxyl group at the 12-position of the aglycone. Erythromycin B: not having a hydroxyl group at the 12-position of the aglycone. Erythromycin C: active as erythromycin but is present ⏩very small amounts in fermentation liquors Analog ➢B analog is more acid-stable but with lower activity. ➢ C analog differs from erythromycin by the replacement ⏩ methoxyl group on cladinose moiety with a hydrogen atom. @pharmacy241

Chemistry of Macrolides ,Erythromycin Clarithromycin Azithromycin Erythromycin _unstable in acid media _ C6hydroxyl group reversibly attacks the C-9 ketone ⏩giving rise inactive products amino sugar ⏩ desosamine, neutral sugar ⏩ cladinose. chemically modified withprimarily two different goals in mind: (a) Increase its water solubility for parenteral dosage forms (b) Increase its acid stability (and possibly its lipid solubility) for improved oral absorption. Modified derivatives of the antibiotic are of two types: 1. Acid salts of the dimethylamino group of thedesosamine moiety (e.g., glucoheptonate, and thelactobionate). 2. Esters of 2'-hydroxyl group of desosamine (e.g., the ethylsuccinate and thepropionate)

المركبين الثانيات بديلات عن Camptothecins حفضوهن كالاتي هاي المجموعة otecan دگله توب top يجي أرين Irin يگلها ماتوب😅😂

Organic pharmaceutical chemistry III 4th Stage Lecture 5 Antineoplastic agents

Organic pharmaceutical chemistry III4th Stage Lecture 4Antineoplastic agents السترگجرات للمحاضرة الرابعه

Cephalosporins الصورة المو واضحة كلولي ادزها اوضح #عضوية رابعة