4th stage question_60

92 Nasal insufflation is the main method in abuse of : A. Marijuana B. Cocaine C. Lsd D. Heroin E. Khat

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In treatment of alcohol withdrawal , which of following shoud be given in all cases?? A/pyridoxine B/foluc acid C/Thiamine D/Riboflavin E/Niacin

flushing Dilestrim like reaction reaction similar to that seen with the combination of metrodiazole and ethanol due to A.high blood acetaldehyde concentration B.genetic deficiency in the activity form of aldehyde dehydrogenase. C. deficiency in aldehyde dehydrogenase D. A+B

Sex difference realted blood concentration of alcohol women have a higher peak concentration than men : A/Lower body content in woman B/Higher body content IN woman C/Low gastric ADH in woman D/A&C E/high gastric ADH in woman

Mechanism implicated in tissue damage of alcohol: A/decreased oxidativr stress B/depletion of glutathione C/damage to mitochondria D/B&C E/growth factor regulation

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Physical findings that usually consistent with the anticholinergic toxicity in CA, are a. Tachycardia b. Hypotension c. Dry skin and mucous membranes d. Mydriasis e. all above

About Medical/Legal Pitfalls of CA toxicity all true except : A/Use of physostigmine. B/Use of flumazenil C/Serum Alkalinization D/Ipecac syrup E/Use of type IA and IC antidysrhythmics

Which of the following is true about screening of CA toxicity: A) blood gas for acidosis B)ECG C) Chest x ray D)CBC E)all above**

4. مال تحديد العمر مكرر (منزّل فوق) 84. All the following are mechanisms of CA toxicity except: A) Inhibiton of serotonin and norepinephrine reuptake B) Anticholinergic activity C) Increasing K permeability into cells D) Alpha adrenergic blocking action E) Blocking sodium from entering cardiac myocytes C

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About Acetaminophin toxicity ,all true except A/Paracetamol is suitable substitution for aspirin if aspirin is cintraindicated B/It is opioid synthetic C/Rumack _math nomogram at level 200 mg/ml at 4h postingestion are associated with high probability of toxicity D/ E/

77- According to acetaminophen all the following are true except: A- The Rumack-Matthew nomogram is utilized to identify proper course of treatment. B- NAC is a glutathione substitute and use as treatment . C-Acetaminophen should not be administered for more than 10 days. D-The total daily dose of acetaminophen should not exceed 4 g. E-Induction of emesis is recommended.

About paracetamol overdose *administration of 30 tablets of paracetamol (500 my each) can result in hepatotoxicity *very small proportion is metabolized via the cytochrome P450-mixed-function oxidase pathway *coagulopathies and jaundice are symptoms of the third stage *methionine is a specific antidote for paracetamol overdose * acetaminophen overdose depletes endogenous glutathione stores

76_ Regarding to Acetaminophen toxicity, the incorrect statement is: 1_Oral ingestion is the most common route for both accidental and intentional exposure to acetaminophen. 2_Renal toxicity is the primary toxic insult from acute Acetaminophen over dose * 3_ Alcoholics have higher risk than normal person. 4_Calculation of body burden if no reliable history of time of ingestion 5_NAPQI is a toxic intermediate of Acetaminophen Toxicity

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Ecothiopate is used as A. A gas nerve agent B. A pesticide C. A petroleum additive D. An ocular medicine ✓ E. All above