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The rapid development and authorization of mRNA vaccines by Pfizer-BioNTech (BNT162b2) and Moderna (mRNA-1273) in 2020 marked a significant milestone in human mRNA product application, overcoming previous obstacles such as mRNA instability and immunogenicity. This paper reviews the strategic modifications incorporated into these vaccines to enhance mRNA stability and translation efficiency, such as the inclusion of nucleoside modifications and optimized mRNA design elements including the 5’ cap and poly(A) tail. We highlight emerging concerns regarding the wide systemic biodistribution of these mRNA vaccines leading to prolonged inflammatory responses and other safety concerns. The regulatory framework guiding the biodistribution studies is pivotal in assessing the safety profiles of new mRNA formulations in use today. The stability of mRNA vaccines, their pervasive distribution, and the longevity of the encapsulated mRNA along with unlimited production of the damaging and potentially lethal Spike (S) protein…
The food transition requires a comprehensive transformation akin to the energy transition, on both an incremental and a systemic level.
Le lapsus, c'est l'inconscient qui surgit au cœur du discours conscient pour le ramener à la vérité. Lapsus révélateur de Manuel Valls : " Tout
The National Defense Authorization Act passed without objection on a 217-199 vote in the House to authorize more than $895 billion in funding.
Johnson & Johnson has agreed to pay states $700 million to settle talcum powder lawsuits filed against the company. Plaintiffs say J&J’s talc products caused them to develop cancer.
Where are the 85,000 missing children? - BIDEN ADMINISTRATION SENDING CHILDREN TO HOUSES NOW ABANDONED Muckraker has obtained a list of addresses where some of the 85,000 missing alien children have been delivered under the Biden administration. Shockingly, one of the addresses
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