MHRA YELLOW CARD REPORTING SUMMARY UP TO 30th AUG 2023
New interactive format data
Adult & Child - Primary, Third Dose & Boosters (mono/bivalent)
Government data (archived) up to Sept 2022 showed
53.8 million people had received a 1st dose UK-wide
By week ending 2 July 2023,
71.1% (3,856,204 out of 5,423,074) people
aged over 75 years old and
41.2% (915,421 out of 2,223,120) people
aged 5 years and over who are immunosuppressed (England only) had a
Spring 2023 booster since 3 Apr 2023
UKHSA National Flu & Covid-19 Surveillance Report - week 35
Yellow Card Adverse Event Reports - 177,307 (Pfizer-mono) + 5034 (Pfizer-bivalent) + 248,490 (AZ) + 43,009 (Moderna-mono) + 5463 (Moderna-bivalent) + 82 (Novavax) + 2602 (Unknown brand) =
481,987 people impacted (increase of 329 in 5 weeks)
Reports classified as SERIOUS* by MHRA = 74.5% of all reports
125,558 (Pfizer-mono) + 3897 (Pfizer-bivalent) + 192,550 (AZ) + 31,124 (Moderna-mono) + 3991 (Moderna-bivalent) + 60 (Novavax) + 1887 (Unknown) =
359,067
Over 46,328 of the above serious reports are of ‘Unknown Age’ = 12.9% of all serious reports
Reports classified as Non-SERIOUS by MHRA = 25.0%
50,856 (Pfizer-mono) + 1093 (Pfizer-bivalent) + 54,527 (AZ) + 11,793 (Moderna-mono) + 1424 (Moderna-bivalent) + 22 (Novavax) + 629 (Unknown) =
120,344
Overall 1-in-112 people injected experiences a Yellow Card Adverse Event (assuming one person submits only one report)
1-in-150 reports are classified as SERIOUS*
1-in-187 reports are associated with a fatality, which
may be less than 10% of actual figures according to MHRA
Reactions - 512,038 (Pfizer-mono) + 13,515 (Pfizer-bivalent) + 881,718 (AZ) + 141,326 (Moderna-mono) + 14,986 (Moderna-bivalent) + 250 (Novavax) + 8005 (Unknown) =
1,571,838
Fatal - 893 (Pfizer-mono) + 44 (Pfizer-bivalent) + 1413 (AZ) + 92 (Moderna-mono) + 48 (Moderna-bivalent) + 86 (Unknown) =
2576 = 0.5% of all reports (increase of 12 reports with fatal outcome in 5 weeks)
Over 405 of the above fatalities are of ‘Unknown Age’ = 15.7% of all fatalities, and >147 are of ‘Unknown Sex’ = 5.7% of all fatalities
CHILDREN & YOUNG PEOPLE SPECIAL REPORT
4,213,500 children (1st doses) - majority Pfizer (latest available dose total from Nov 2022)
Yellow Card Adverse Events Reported - Below combined 0-19yrs - many categories “retracted (
^) due to less than 5 reports in line with MHRA duty of confidentiality to patients and reporters”
0-19yr old reports classified as SERIOUS* by MHRA = 71.4%
4679 (Pfizer-mono) + >41 (Pfizer-bivalent) + 1462 (AZ) + 518 (Moderna-mono) + >7 (Moderna-bivalent) + >36 (Unknown) =
6743
0-19yr old reports classified as FATAL by MHRA
>11 (Pfizer-mono) + <5 (Pfizer-bivalent) + <5 (AZ) + <5 (Moderna-mono) + <5 (Moderna-bivalent) + <5 (Unknown brand) =
greater than 17
20-29yr old reports classified as SERIOUS* by MHRA = 73.3%
20,039 (Pfizer-mono) + 127 (Pfizer-bivalent) + 14,569 (AZ) + 4985 (Moderna-mono) + 137 (Moderna-bivalent) + < 5 (Novavax) + 99 (Unknown) =
39,956
20-29yr old reports classified as FATAL by MHRA
15 (Pfizer-mono) + <5 (Pfizer-bivalent) + 29 (AZ) + zero (Moderna-mono) + zero (Moderna-bivalent) + zero (Novavax) + <5 (Unknown brand) =
greater than 45
* MHRA definition of ‘serious’ - patient died, life threatening, hospitalisation, congenital abnormality, persistent or significant disability or capacity, deemed medically significant by MHRA medical dictionary or reporter
For full reports - https://yellowcard.mhra.gov.uk/idaps