pharmacy all semester notes and study material previous year qus
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B PHARMACY previous year qus paper NOTES , BooKs ( B/D PHARMACY) π’ Search the name of file and you got it in channel #pharmacynotes #PharmaD #medical #Pharmacist #Dpharmacy π JOIN US AND SUPPORT
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Channel Posts
| 2 | AT_ P'Cognosy Chart-1.pdf | 915 |
| 3 | Shikimic Acid P. (5M).pdf | 913 |
| 4 | Anthraquinone G. (5M).pdf | 917 |
| 5 | POC AT Unit-1.pdf | 920 |
| 6 | Complexation _AT.pdf | 920 |
| 7 | Pharmaceutical Analysis -1 (notes).pdf | 924 |
| 8 | PJ-2M.pdf | 914 |
| 9 | POC 2M.pdf | 896 |
| 10 | Tablet Excipients (10M).pdf | 868 |
| 11 | Unit 3 AT POC.pdf | 838 |
| 12 | Note on analysis Of Fats & Oils | 809 |
| 13 | Tracer technique (10M).pdf | 800 |
| 14 | KEPPRA | 1 231 |
| 15 | KEPPRA | 1 |
| 16 | CVS
PART 1: ANATOMY OF CARDIOVASCULAR SYSTEM
1οΈβ£ HEART β Structural Anatomy
Location
Middle mediastinum
Between lungs
Apex at left 5th intercostal space
Coverings
Pericardium (fibrous + serous)
2οΈβ£ Layers of Heart Wall
Endocardium (inner)
Myocardium (muscular layer)
Epicardium (outer)
Myocardium thickness:
Left ventricle > Right ventricle (because systemic circulation requires more force)
3οΈβ£ Chambers and Flow Sequence
Venous blood β
Right Atrium β Tricuspid Valve β Right Ventricle β Pulmonary Valve β Lungs β
Left Atrium β Mitral Valve β Left Ventricle β Aortic Valve β Aorta β Body
4οΈβ£ Conducting System of Heart
Sequence
SA node β AV node β Bundle of His β Right & Left bundle branches β Purkinje fibers
SA node = natural pacemaker (60β100/min)
AV node delay allows ventricular filling
PART 2: PHYSIOLOGY (FUNCTIONAL CONCEPTS)
1οΈβ£ Cardiac Cycle
Duration β 0.8 sec
Phases:
Atrial systole
Ventricular systole
Diastole
2οΈβ£ Stroke Volume (SV)
Amount pumped per beat β 70 mL
3οΈβ£ Cardiac Output (CO)
CO = SV Γ HR
= 70 Γ 70 β 5 L/min
Regulation:
β Sympathetic β β HR + β contractility β β CO
β Vagal tone β β HR β β CO
4οΈβ£ Blood Pressure
BP = CO Γ Peripheral Resistance
Normal: 120/80 mmHg
Determinants:
Cardiac output
Total peripheral resistance
Blood volume
Elasticity of vessels
PART 3: REGULATION OF BLOOD PRESSURE
1οΈβ£ Neural Regulation (Short term)
Baroreceptors:
Carotid sinus
Aortic arch
If BP β β Baroreceptor firing β β β sympathetic β BP falls
2οΈβ£ Renal Regulation (Long term)
Kidney controls:
Sodium balance
Water balance
RAAS system
3οΈβ£ RAAS SYSTEM
β BP β Kidney releases renin β
Renin converts Angiotensinogen β Angiotensin I β
ACE converts β Angiotensin II β
Angiotensin II:
Potent vasoconstrictor
β Aldosterone
β Sodium retention
β BP
PART 4: PATHOPHYSIOLOGY OF MAJOR DISORDERS
1οΈβ£ HYPERTENSION
Definition: Persistent BP > 140/90 mmHg (exam value)
Types:
Primary (90β95%)
β RAAS activity
Sympathetic overactivity
2οΈβ£ CONGESTIVE HEART FAILURE (CHF)
Definition: Heart unable to pump adequate blood.
Pathophysiology: β CO β Kidney senses low perfusion β RAAS activated β Fluid retention β Edema
Compensatory:
Ventricular hypertrophy
Sympathetic stimulation
3οΈβ£ ANGINA PECTORIS
Cause: Imbalance between oxygen supply and demand.
Types:
Stable
Unstable
Variant (Prinzmetal)
4οΈβ£ ARRHYTHMIA
Abnormal impulse:
Formation problem
Conduction problem
Causes:
Ischemia
Electrolyte imbalance
Drug toxicity (e.g., digoxin)
PART 5: PHARMACOLOGY
1οΈβ£ ANTIHYPERTENSIVE DRUGS
Classification:
A. Diuretics
Thiazides (Hydrochlorothiazide)
Loop (Furosemide)
KβΊ sparing (Spironolactone)
Mechanism: β Blood volume β β CO β β BP
B. Sympatholytics
1. Beta blockers
Propranolol
Atenolol
Metoprolol
Mechanism: β HR + β Renin release
2. Alpha blockers
Prazosin
Mechanism: Vasodilation
3. Central acting
Clonidine
Methyldopa
Mechanism: β Sympathetic outflow
C. RAAS Inhibitors
ACE inhibitors:
Enalapril
Ramipril
ARBs:
Losartan
Telmisartan
Direct renin inhibitor:
Aliskiren
D. Calcium Channel Blockers
Amlodipine
Verapamil
Diltiazem
Mechanism: β CaΒ²βΊ entry β Vasodilation β β BP
2οΈβ£ DRUGS FOR CHF
Diuretics
ACE inhibitors
Beta blockers
Aldosterone antagonists
Digoxin
Vasodilators
SGLT2 inhibitors
3οΈβ£ ANTIANGINAL DRUGS
Nitrates β Venodilation β β Preload
Beta blockers β β Oxygen demand
CCB β Vasodilation
Ranolazine
Ivabradine
4οΈβ£ ANTIARRHYTHMICS
Class I β NaβΊ channel blockers
Class II β Beta blockers
Class III β KβΊ channel blockers
Class IV β CaΒ²βΊ channel blockers
Others:
Adenosine
Digoxin
Magnesium sulfate
5οΈβ£ DIURETICS (Nephron Based)
PCT β Acetazolamide
Loop of Henle β Furosemide
DCT β Thiazides
Collecting duct β Spironolactone | 1 506 |
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