🩺Medical Courses-IUA-B25🩺
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✨كويزات وملخصات يتم تقديمها من الطلاب في مختلف المواد لباقي أفراد الدفعة لتعم الفائدة للجميع ✨ ____________________________________ •رابط قناة التيلقرام : https://t.me/Coursesbatch25 •رابط قناة الواتس : https://whatsapp.com/channel/0029VaNK05a8vd1YlsIN
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Questions:
1. Combination of protein hormones with the receptors lead to regulation of activities of the target proteins by two ways ,mention them?
2. Explain the action when hormone bind to G- protein binding site?
3. Explain the second messenger mechanism?
4. Explain the action of steroid hormones on genetic machinery?
5. Explain the action of thyroid hormones on genetic machinery?
6. Explain cAMP cascade?
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Cyclic AMP and and phosphatidyl inisitol are examples of second massengers
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Oxytocin during labor is an example for
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When the biological action cause additional secretion of the hormone this called positive feedback
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The negative feed back mechanism effects to prevent:
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Lipid soluble hormones circulate in blood bound to plasma proteins, with a little percentage exist in free form
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Peptides and tyrosine derivatives hormones transport in blood through dissolving in plasma and transported up to reach their target tissues
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Steroids and thyroid hormones has a delayed onset of action and acting for short time
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All these hormones act on genetic machinery except:
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G- protein is a transmembrane protein that wind 7 times back and froth through the plasma membrane with binding site facing outside and effector one facing interiorly
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The facilitation of the action of hormone by another hormone called:
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In down regulation, internalization, inactivation, destruction and decrease production of receptors occur to decrease hormone receptors number.
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Down regulation of receptors occur when there is a deficiency of hormone to increase the number of the receptors
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Cell receptors can be either down or up regulated
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Retinoid and thyroid hormones have a cell nucleus receptors
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Examples of cell surface receptors hormones
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Receptors may found in cell surface, cytoplasm, of nucleus
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Large proteins highly specific for a single hormone
