1 527
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1 526
لاحظ الفرق بين :
Fat accumulation, Far Necrosis
Fat necrosis with Ca Deposition
#معمل_باثو
#سلايدات
1 526
❗️Diagnosis:
Fat Necrosis Microscopically
❗️Characteristic features:
Necrosis of far cell with perserved outline of the cell + Calcification (Ca Deposition)
#معمل_باثو
#سلايدات
1 526
❗️Diagnosis:
Fat Necrosis ( Due to acute Pancerititis )
❗️Characteristic features:-
White shalk appearance ( Saponification)
#معمل_باثو
#سلايدات
1 526
❗️Diagnosis :
Caseous Necrosis of TB in lung
❗️Characteristic features:-
area of Acellular, amorphus, esionphilc , Heamogenous , surrounded by Granulomatous inflammation.
#معمل_باثو
#سلايدات
1 526
❗️Diagnosis :
Caseous Necrosis of TB in lung
❗️Characteristic features:-
Cheese like appearance of lung ( Gross)
#معمل_باثو
#سلايدات
1 526
❗️Diagnosis :
Caseous Necrosis of TB in lung
❗️Characteristic features:-
Cheese like appearance of lung ( Gross)
#معمل_باثو
#سلايدات
1 526
❗️Diagnosis:-
Liquifactive necrosis Microscopically
❗️Characteristic features:-
Cystic space containing cell debris
#معمل_باثو
#سلايدات
1 526
❗️Diagnosis:
Gross picture of Liquifactive necrosis of the Brain.
❗️Characteristic features:
Loss of Tissue architecture
Replaced by fluid-filled sacs due to lysosmoal enzymes action
#معمل_باثو
1 526
❗️Diagnosis:
Coagulative Necrosis of the Liver
❗️Characteristic features:-
Dead cell ( Without nucles) without losing their Architecture ( Cell outline)
#معمل_باثو
#سلايدات
1 526
❗️Diagnosis:-
Area of Infarction of Kidney ( Coagulative Necrosis) Gross
❗️Characteristic features:-
Infarct yellow area with perserved outline
#معمل_باثو
#سلايدات
1 526
✨ Cell Necrosis ✨ :
Types :
🔥1 - Coagulative Necrosis:
( Dead Cell without nucleus - still has its architecture)
Without losing the outline of the cell
اللي بيحصل مثل ما قلنا Hypoxia ..
فتلجأ الخلية لل Anerobic energy واللي بتؤدي الى تكوين وتراكم ال lactic acid داخل الخلية واللي بيغير الوسط فيها الى حمضي Acidic هذا الكلام بيؤدي الي denaturation of proteins .. فتموت الخلية و تتوقف الانزيمات عن العمل ..قبل مايحصل لها Autolysis .. فننتظر لل Phagocytosis يخلصنا منها ..
🔥2- Liquifactive necrosis:-
( Lose Of tissue architecture >> replaced by fluid )
Ischemia of Brain
ومثل ما احنا عارفين ال Brain ما يقدر يعيش من غير Oxygen .. ما بيسوي Anerobic ومافيش لاكتيك Acid
بالتالي ال Autolysis of the Cell
🔥3- Caseous Necrosis :-
Gross : yalloe cheese appearance
وعارفين جدا اول ما نسمع عن ال Caseous Necrosis على طول يجيب في بالنا ال TB
Microscopicall :
Lose of Architecture
بنشوف منطقة ال Necrosis على هيئة
Acellular -esionphilc
Surrounded by Granulomatous inflammation
🔥 Fat Necrosis:
نتيجة ال Abnormal metabolism of fat
بنشوفها في ال Pancreas / Breast
Gross: White shalk appearance ( Saponification )
Microscopically:- Outline of cell is perserved >>> Fat accumulation + Ca
( Clacification)
🔥 Fibrinoid Necrosis :
Necrosis >> In Blood Vessels
Charecteriszed by Fibrin deposition
>> Esionphilc amorphus appearance
🔥 Gangrenous Necrosis:-
Necrosis with puterification
Mix all Type of Necrosis
#معمل_باثو
#مجموعة_الباثو
#اللجنة_العلمية
@batch34notes
1 526
❗️Diagnosis
Irreversible cell Injury
❗️Characteristic features:-
Karyolysis of the Nucleus ( Soup apperance)
#معمل_باثو
#سلايدات
1 526
❗️Diagnosis
Irreversible cell Injury
❗️Characteristic features:-
Karyorhexis of the Nucleus ( Fregmentation)
#معمل_باثو
#سلايدات
1 526
❗️Diagnosis
Irreversible cell Injury
❗️Characteristic features:-
Pyknosis of nucleus ( condensation)
#معمل_باثو
#سلايدات
1 526
❗️Diagnosis
Irreversible cell Injury
❗️Characteristic features:-
Dense bodies in mitochondria
1 526
✨ Irreversible cell Injury ✨
لما يكون عندي Severe injurious agent
توصل بالخلية لمرحلة ال Point of No return
فتدخل الخلية ب Irreversible damage
ممكن يكون Chronic و ياخذ وقت طويل مثل ال Cellular accumulation
ممكن Acute وتموت الخلية ..
Cell Death ممكن يكون بصورتين
💀 Apoptosis >> Programmed cell death or suicidal death of cell
وتكون single و Doesn't cause inflammation
💀Necrosis: Due to Certain severe injury >> Happens to Whole The Tissue >> Causes Inflammation
طبعاً عشان نقول هذي الخلية دخلت في Irreversible damage او الخلية تنازع و بيحصل لها Necrosis
تحصل تغيرات في الخلية ... لها علاقة بالصوديوم بوتاسيوم بامب , بالميتوكوندريا
في تغيرااااااات بالتحديد تحصل لل Nucleus :- يعني لل DNA
وممكن الاحظها بال Electron Microscope
👹 1- Pyknosis :
Condensation of DNA
👹2- Karyorhexis:
Fregmentation of DNA ( تتقسم )
👹3- karyolysis :
Lysis of Dissolving >> Dissaperance
#معمل_باثو
#مجموعة_الباثو
#اللجنة_العلمية
@batch34notes
1 526
❗️ Diagnosis:
Accumulation of lipid & Protein
❗️ Characteristic features:-
Cells filled with fat & esionphilc materials ( Proteins )
#معمل_باثو
#سلايدات
1 526
❗️ Diagnosis:
Fatty change of liver ( Accumulation of fat )
❗️ Characteristic features:-
Cells filled with fats ( Enlarged)
#معمل_باثو
#سلايدات
