4th Stage chennels and Important things

Q/ bone change in SCA (two) 1-cystic change in the phalanges and thickening of periosteum ,long term sequel short digital ,epiphysis closure of long metacarpal 2-in the femur a vascular necrosis (adhesion of whole acetabulam )

1-Acute chest syndrome: life threatening conditions 2- admmision,warmth, control infection,control pain, hydration,avoid precipitation factor, give him O2 if less than 92, and blood transfusion if anemic 3-because he is adult, he may have autosplencetomy

Lec. 8 جواب السؤال الاخير هيموكولوبين مو rbc

بس ممتاكدين منة

الكوزات بفايل واحد

1- intravascular hemolysis due to drug induced in patient most likely have G6PD deficiency 2-blood film: reticulocytosis, bite cell...... Urine:hemoglobinurea..... G6PD Level only in recovery phase 3- avoid trigger and this treatment

Parvo virus B19 causes aplastic crisis (pure red cell aplasia)

1- hemolytic anemia(hemolysis) 2- s. Bilirubin + blood film reticulocytosis + S. LDH................... 3- Extravascular

Adverse effects of cyclosporin: hirsutism, gum hypertrophy, hypertension, nephrotoxicity, hepatotoxicty

Lec 6 👆👆

1-decrease in all blood cell elements (pancytopenia with normal morphology) 2- BM biopsy 3- supportive treatment

1- macrocytosis due to megaloblastic anemia (B12 D.) OR due to hypothyroidism 2- subacute combind degeneration of the spinal cord 3- bone marrow study to exclude other causes of megaloblastic disorder like MDS Serum B12 and folate to differenate this combind defiency or only folate 4-pernicious anemia causing B12 defeciency resulting in megaloblastic anemia with subacute combind degeneration of the spinal cord

1)) 1-anemia of chronic disease because he have underlying chronic diseases and mild haemoglobin defect and accidently discovered 2- may he have peptic ulcer that induced by NSAID and asprin and he have dyspepsia so may develop IDA 2)) 1-MCV : IDA more smaller(sever microcytosis) 70fl or less, ACD may normocytic 80fl or more in 80% of cases and if microcytic it is mild (70-80 fl) 2-TIBC or transferrin conc. is high in IDA but normal or low in ACD 3-soluble transferrin receptor: high in IDA and low in ACD 3)) accordingly if IDA ==> Iron If ACD ==> control underlying chronic disease and give him Erythropoiesis stimulating agent like Erythropotien **Aspirin as prophylaxis to ischemic heart disease NSAID to treat joint pain in RA

كمل لكجر 4 هو واسئلته

الجواب مال الترانسفرين رسبتر

1- 10 2- blood loss 3- microcytosis, anisocytosis.... 4- S. Iron,, TIBC,, S. FERRITIN