نکات

رفته پذیرش مرکز رادیولوژی به بیمار گفتن اصلا چیزی به اسم سونوگرافی تاندون و‌ مفاصل وجود نداره. یاد بگیریم به جای «وجود نداره» بگیم «ما نداریم» یا «ما بلد نیستیم»

VIZZ (aceclidine ophthalmic solution), approved by the FDA, represents the first breakthrough treatment for presbyopia in decades. This revolutionary prescription eye drop treats the 128 million American adults struggling with age-related blurry near vision by creating a precise "pinhole effect" that extends depth of focus without compromising distance vision.⁠ ⁠ Unlike traditional presbyopia treatments, VIZZ works within 30 minutes and lasts up to 10 hours with a single daily application. The drop contains aceclidine, a pupil-selective compound that contracts the iris sphincter muscle to achieve a sub-2mm pupil diameter—essentially turning your eye into a perfectly focused camera lens. LENZ Therapeutics CEO Eef Schimmelpennink emphasized the significance: "This represents a transformative improvement in available treatment options for the 128 million adults living with blurry near vision in the United States".⁠ ⁠ What sets VIZZ apart from previous presbyopia drops like Vuity is its targeted mechanism of action. While earlier treatments affected both the pupil and ciliary focusing muscles (causing side effects like brow heaviness), aceclidine predominantly targets the iris with minimal ciliary muscle stimulation, eliminating the "myopic shift" that blurred distance vision.⁠ ⁠ Clinical trials involving over 30,000 treatment days demonstrated remarkable safety and efficacy across three Phase 3 studies. Dr. Marc Bloomenstein from Schwartz Laser Eye Care called the approval "a disruptive paradigm shift" that could "immediately become the standard of care" for millions frustrated by inevitable age-related vision loss.⁠ ⁠ The treatment offers hope for the universal condition affecting everyone over 40, potentially replacing the daily inconvenience of reading glasses with a simple morning eye drop routine.

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The aging kidney: cysts & tumors پیر شدن کلیه: کیست و تومور #uptodate

Good Life Philosophers and psychologists have long defined the "good life" in two ways: one of happiness, marked by pleasure and positive emotions, or one of meaning, rooted in purpose and fulfillment. Now, new research suggests there is a third, equally vital path, psychological richness, a life filled with experiences that change perspectives and spark curiosity. Led by Erin Westgate of the University of Florida and Shigehiro Oishi of the University of Chicago, the study shows that many people value variety, novelty, and intellectual challenge, even when those experiences are difficult or uncomfortable. Unlike happiness, which is about feeling good, or meaning, which is about doing good, psychological richness is about thinking differently and seeing the world in new ways. Examples of this richness can range from traveling or starting a new hobby to reading a profound book or hearing a haunting piece of music. These experiences need not be pleasant or purposeful. College, for instance, often involves stress and uncertainty but reshapes how people think. Even events like hurricanes, which the team studied among students in Florida, were described as "psychologically rich" because they forced new perspectives, despite being neither happy nor meaningful. The researchers found that people with greater openness to experience, a key personality trait, were more likely to pursue psychological richness. Careers and lifestyles also reflect these choices: some prioritize financial satisfaction, others meaning, and still others freedom, creativity, and novelty. While many people desire all three, happiness, meaning, and richness, rich experiences often come at the cost of comfort or clarity. The findings highlight that living well is not one-size-fits-all. For some, the most fulfilling path is not the safest or most comfortable, but the one that challenges, surprises, and transforms how they see the world.

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📍📍Arrhythmias contraindicate to DC shock: 1-Digitalis induced arrhythmia 2-MAT 3-AF without anticoagulant 4-Junctional tachycardia 5-kalemia induced arrythmia. 6-TCA induced arrythmia 7-Pulseless electrical activity

📍The most common cause of death in aortic dissection is cardiac tamponade. In a pateint of aortic dissection, Severe hypotension at presentation is a grave prognostic indicator. It is usually associated with pericardial tamponade, severe aortic insufficiency, or rupture of the aorta.

‌ «خطای بقا» به خصوص وقتی عضو تیم «برنده» باشی می‌تواند بسیار مخرب باشد. حتی اگر موفقیت تو ناشی از تصادف محض باشد، شباهت‌هایی با سایر تیم‌های برنده پیدا میکنی که وسوسه می‌شوی از این‌ها به عنوان «عوامل موفقیت» یاد کنی. اما اگر به گورستان افراد و شرکت‌های ناموفق سر بزنی، متوجه خواهی شد ساکنان آنجا هم خیلی از خصوصیاتی را داشته‌اند که از علل موفقیت تو هستند. «خطای بقا» یعنی افراد دایما احتمال موفقیت خود را زیادتر از حد تخمین بزنند. با سر زدن به قبرستان پروژه‌ها، سرمایه‌گذاری‌ها و شغل‌هایی که در زمانی بسیار امیدوارکننده به نظر می‌رسید، در برابر این خطا موضع بگیر. قدم زدن در این قبرستان ناخوشایند ولی برای شفاف شدن ذهنت لازم است. یادداشتی از کتاب «هنر شفاف اندیشیدن» اثر رولف دوبلی، ترجمه عادل فردوسی‌پور #TheArtOfThinkingClearly