Lina Sudanses local Derma Telegram

Plasminogen activator

Answer

Esinophil stimulator: A. C5a B. Plasminogen activator

■1412 Local derma part 1 2022

Cicatricial pemphigoid also called Mucous membrane pemphigoid (MMP) is a heterogeneous group of blistering disorders affecting the mucosae with or without skin involvement, characterized by the presence of autoantibodies to components of the basement membrane zone, including the bullous pemphigoid antigen BP180 and β4 integrin. patients whom present circulating antibodies to laminin-332 seems to be associated with a relatively high risk of malignancy

Explanation

Laminin

Answer

Cicatricial pemphigoid with adenocarcinoma defected gene to look for is: A. Collagen 7 B.Laminin C. Profilaggrin D. Involucrin

■1411 Local derma part 1 2022

In Pemphigud Foliaceous and pemphigus erythematosus, acantholysis is usually confined to the sub-corneal layer due to involvement of Dsg1 《desmoglein 1》, which is distributed predominantly in the upper epidermis.

Explanation

Desmoglein 1

Answer

Pemphigus folicaceous target A. Desmoglein3 B. Desmoglein 1 C. Connexin

■1410 Local derma part 1 2022

Keratinocytes proliferate in the basal layer of the epidermis and start differentiating on their way to the surface, undergoing gradual differentiation. In the basal layer of the skin, the innermost stratum, a basal keratinocyte has just divided by mitosis to form a new basal keratinocyte. This new cell starts to divide itself and produces many more keratinocytes. Some of these cells will stay with their parent and continue to replenish the population of basal keratinocytes. These cells are known as stem cells. However, other cells will start a process of differentiation.. Over time, the these differentiating cell are pushed upwards as the next generation of cells forms underneath them. Eventually, they are pushed into the next layer of the skin to become prickle cells (spinous cells) . As more and more cells are made in the basal layer, the newly formed prickle cells continue getting pushed upwards and eventually they reach the granular layer. Here, the cells undergo a semi-apoptotic series of events in which their cell organelles and nucleus are degraded overtime. Once they’ve been pushed into the highly keratinized squamous layer and become squames. These cells are very flat and eventually they flake off as dead skin cells. With each stage, the cells produce a different profile of keratin proteins in a process known as terminal cell differentiation

Explanation

Movement of cell from basal layer to corneal layer with keratin formation

Answer