قسم pathology للدفعة الخامسة

#MICROSCOPIC #Diagnosis → non seminoma choriocarcinoma #The_brown_arrows Haemorrhage #The_black_arrow Cytotrophoblast - clear cytoplasm - irregular nuclei - Prominent nucleoli #The_blue_arrows Syncytiotrophoblast - larger cell with numerous nuclei - hyperchromatic nucleus - smudge chromatin - elongated cytoplasm

#GROSS #Diagnosis → non seminoma choriocarcinoma #Features Soft friable tumor Severe haemorrhage It forms placental tissue

#MICROSCOPIC #Diagnosis → non seminoma embryonal carcinoma #The_black_arrows RBCs #Features It has a papillary structure but without Schiller Duval body inside Its cells larger than yolk sac's cells

#GROSS #Diagnosis → non seminoma embryonal carcinoma #The_blue_arrows Necrosis #The_black_arrows Haemorrhage #Features It has a worse prognosis than yolk sac tumour

#MICROSCOPIC #Diagnosis → non seminoma yolk sac tumour #The_black_arrows Hyalinized stroma in globular structure #The_brown_arrows Cancer cells

#MICROSCOPIC #Diagnosis → non seminoma yolk sac tumour #The_black_arrows Schiller Duval bodies in tubular (finger-like) structure

#MICROSCOPIC #Diagnosis → non seminoma yolk sac tumour #The_blue_arrows Cancer cells #The_black_arrow Schiller Duval body

#MICROSCOPIC #Diagnosis → non seminoma yolk sac tumour #The_blue_arrows Hyalinized stroma (pink, AFP) #The_black_arrows Schiller Duval bodies (red) #Features Small hyperchrmatic pleomorphism cells It has a papillary structure with Schiller Duval body inside ✓ Alfa fetoprotein is elevated

#GROSS #Diagnosis → non seminoma yolk sac tumour #The_blue_arrow Haemorrhage #The_black_arrow Necrosis #The_brown_arrows Cystic areas #Features Irregular, ill-defined shape Poorly circumscribed

#MICROSCOPIC #Diagnosis → spermatocytic tumour #The_blue_arrow bizzar nucleus cell #Features Highly pleomorphism Prominent nucleoli with clear cytoplasm Hyperchromatic cells NO INFLAMMATORY CELLS NO FIBROUS SEPTAE

#MICROSCOPIC #Diagnosis → classic seminoma germ cell neoplasm #The_blue_arrows Inflammatory cells (lymphocytes) #The_black_arrow Fibrous septae (pink in color) #The_brown_arrows Prominent nucleoli with clear cytoplasm

#MICROSCOPIC #Diagnosis → classic seminoma germ cell neoplasm #The_blue_arrows Inflammatory cells (lymphocytes) #The_black_arrow Fibrous septae (pink in color)

#GROSS #Diagnosis → classic seminoma germ cell neoplasm #The_black_areas Rounded lobulated yellow-white masses #Features No necrosis No haemorrhage Well circumscribed

▪️classic Seminoma - has good prognosis - patients 30-40 years old - tumor marker is PAP (prostatic alkaline phosphatase) #gross features - yellowish- white mass - lobulated - well circumscribed - No hemorrhage, No necrosis #microscopic features - large round cells - large nuclei ( hyperchromatic) - prominent nucleoli - clear cytoplasm - cells arranged in sheets or lobules with septa in between - lymphocyte within the septa

#MICROSCOPIC #Diagnosis → intratubular germ cell neoplasia #The_black_arrows Prominent nucleoli with clear cytoplasm #The_blue_arrows The border of the tubule

#MICROSCOPIC #Diagnosis → intratubular germ cell neoplasia #Features الخلايا السرطانية لازالت في الـ tubule (no invasion) Clear cytoplasm Round prominent nucleoli

#MICROSCOPIC #Diagnosis → cryptorchidism #The_black_rhomboid Atropic tubule with no spermatogenesis #The_blue_arrows Pale stroma

#GROSS #Diagnosis → cryptorchidism #Left_kidney Atropic Pale white in color

#MICROSCOPIC #Diagnosis → testicular TB #The_black_area Hematogenous area with less nucleus

#GROSS #Diagnosis → testicular TB Caseous necrosis has cheese-like appearance