قسم pathology للدفعة الخامسة

#Gross #Diagnosis 👉🏻 Leiomyoma Arise from myometrium of uterus

Endometrial Adenocarcinoma Microscopic Features: 1)Glandular proliferation 2)Glands with irregular lumen 3)Hyperchromatic & pleomorphic cells 4)Cellular Atypia 5) ⇑ Mitotic figures 6) Intervening endometrial stroma

Endometrial polyp Microscopic features: Black arrow: elongated shape, vascular pedicle ( fibro-vascular core) Red arrows: Accumulation of glandular tissue within the polyp

Endometrial polyp Microscopic Features: 1)Polypoid mass 2)Yellow area ➱ Fibrovascular core 3)Green arrows ➱ Cystically dilated gland 4)Slightly Irregular proliferative glands

Gross endometrial polyps Blue arrow: High in the fundus and projecting into the endometrial cavity is a small benign endometrial polyp, and may cause uterine bleeding.

#MICROSCOPIC #Diagnosis 👉🏻 Chronic endometritid #The_black_arrow Inflammatory cell infiltration (lymphocytes)

Chronic endometritis Microscopic features: Presence of infiltrated lymphocytes and plasma cells in the endometrium Red arrows: Lymphoid Follicles Blue arrow: Plasma cell

Acute endometritis Microscopic features: Black arrow: endometrium with prominent intraluminal segemented neutrophils infiltrating glandular epithelium. Blue arrow: Congested blood

Cervical adenocarcinoma in situ Microscopic features: Red arrows: Irregular lumens of glandular tissue. Blue arrows: Hyperchromatic tumor cells, with peliomorphism. Green arrow: Normal cells

#Microscopic #Diagnosis 👉🏻 squamous cell carcinoma A ➪ Poorly differentiated No keratinous pearls Hyperchrmatic nucleus Cell polymorphism More N/C ratio B ➪ Moderatly differentiated C ➪ Well differentiated

Poorly differentiated invasive cervical squamous cell carcinoma at low grade microscopic. Microscopic features: _ peliomorphism ( hyperchromatic nucleus) Red arrow: inflammatory cells infiltrated Green arrow: nest of atypia tumor cells Blue arrow: Loss of stromal tissue between the cells. Black arrow: Irregular basement membrane

🌸 The Grades of squamous cell carcinoma

Cervical intra-epithelial neoplasia grade 3: Microscopic features: Red arrows: marked full thickness atypia and loss of maturation; carries highest risk of progression to invasive squamous cell carcinoma

Cervical intra-epithelial neoplasia grade 2 Microscopic features: Green arrows: superficial cytoplasmic maturation; high rate of regression. Red arrows: diffuse nuclear enlargement, hyperchomasia. Blue arrows: Note the increased mitotic activity in the lower and middle thirds

Cervical intra-epithelial neoplasia grade 1 High risk from HPV driven precancerous lesion (HPV 16 most common) Microscopic features: Red arrows: full thickness nuclear abnormalities (hyperchromasia, coarse chromatin, irregular nuclear contours and inconspicuous nucleoli), high N/C ratio in at least lower two - thirds of epithelium.

Cervical Intraepithelial Lesion I [CIN I ]✨ ✅Microscopic Features: 1)Green area ➱Dysplasia of the lower 1/3 of tissue 2)Red arrows ➱Koilocytotic changes

Cervical squamous metaplasia✨ *Causes : Superimposed chronic inflammation of endocervical poly may lead to Cervical squamous metaplasia . ✅Microscopic Feature : 1)Yellow area ➱Squamous metaplasia

Endocervical polyp✨(high power) ✅Microscopic Feature: 3)The stroma is edematous (لاحظ وجود الفقاعات الشفافة داخل )

Endocervical polyp✨ (low power) ✅Microscopic Features: 1)Red arrows ➱variably shaped endocervical glands. 2)Blue arrows➱ scattered mononuclear cells infiltrate.

Cervical polyp = Endocervical polyp - inflammatory cells filtered in stroma 💜 purple arrow 💜 - irregular dilated lumen and filled with mucus💙blue arrow💙 - proliferative and hyperplasia of glands🤍white arrow 🤍