Clinical Qbank(2nd year Subjects)

381) Ans. (a) Laminin Ref: Robbin’s Pathology, 9th ed. pg. 105 Laminin is the most abundant glycoprotein in basement membranes. Type IV collagen, laminin and nidogen are present in basement membranes. 🎲For  more questions join @secondyearmbbsquestions and attend Live Quizzes @PrepNEXT at 9:30P.M Daily!!

380 ) . Ans. (c) Kidney Ref: Robbins E-Book, P 519 Good pasture disease is a term used to describe glomerulo- nephritis, with or without pulmonary hemorrhage, and the presence of circulating anti–glomerular basement mem- brane (anti-GBM) antibodies 🎲For  more questions join @secondyearmbbsquestions and attend Live Quizzes @PrepNEXT at 9:30P.M Daily!!

379 ) Ans. (c) Doxycycline Ref: Sharma & Sharma 3rd ed. P 760 • Doxycycline is from the tetracycline class of drug. • Tetracyclins are first line DOC in following conditions like ƒ Rocky mountain spotted fever ƒ Typhus fever ƒ Psittacosis ƒ Granuloma inguinale ƒ Non-specific urethritis (ureaplasma urealyticum) ƒ Lyme disease ƒ Brucellosis (Brucella abortus) ƒ Plague ƒ Pasturella abscess 🎲For  more questions join @secondyearmbbsquestions and attend Live Quizzes @PrepNEXT at 9:30P.M Daily!!

378 ) Ans. (a) Cardiac Ref: Robbin’s Pathology, 9th ed. pg. 1115 • Cardiovascular insufficiency and cerebrovascular accidents are the most common causes of mortality. Theimpact of cardiovascular disease can be gauged by its involvement in as many as 80% of deaths of type 2 diabetics; in fact, diabetics have a 3 to 7.5 times greater incidence of death fromcardiovascular causes than nondiabetic populations. • The hallmark of cardiovascular disease is accelerated atherosclerosis of the large and medium-sized arteries (i.e., macrovascular disease). 🎲For  more questions join @secondyearmbbsquestions and attend Live Quizzes @PrepNEXT at 9:30P.M Daily!!

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377 ) Ans. (c) E- cadherin Ref: Robbin’s Pathology, 9th ed. pg. 307 • Normal epithelial cells are tightly glued to each other and the ECM by a variety of adhesion molecules. • E-cadherin, a cell surface protein, maintains intercellular adhesiveness serving to hold the cells together and relay signals between the cells. • In several epithelial tumors, including adenocarcinomas of the colon, stomach, and breast, E-cadherin function .

376 ) Ans. (c) Apoptosis The councilman bodies are formed due to process of apoptosis in viral hepatitis.

375 ) . Ans. (a) Glucocorticoids Ref: Goodman & Gillman 13th ed. P 851, 809 • Ligands that act by intracellular receptors are classified into nuclear and cytoplasmic. All these ligands acts by nuclear transcription but their receptors are either present in nucleus (nuclear receptor) or in cytoplasm (cytoplasmic receptor). • Glucocorticoids act by binding to a specific glucocorticoid receptor (GRs) that is a member of the nuclear receptor family of transcription factors. • GRs reside predominantly in the cytoplasm in an inactive form complexed with other proteins. Steroid binding results in receptor activation and translocation to the nucleus • The GR translocates to the nucleus and induces complex gene expression changes that lead to antiproliferative and apoptotic responses in sensitive cells. 🎲For  more questions join @secondyearmbbsquestions and attend Live Quizzes @PrepNEXT at 9:30P.M Daily!!

374 ) Ans. (a) cAMP Ref: Katzung, 14th ed. pg. 31 • G-protein receptor for glucagon is Gs which acts via↑Adenylyl cyclase causing ↑ cAMP. 🎲For  more questions join @secondyearmbbsquestions and attend Live Quizzes @PrepNEXT at 9:30P.M Daily!!

373 ) 4. Ans. (a) Laminin Ref: Robbin’s Pathology, 9th ed. pg. 105 Laminin is the most abundant glycoprotein in basement membranes. Type IV collagen, laminin and nidogen are present in basement membranes. 🎲For  more questions join @secondyearmbbsquestions and attend Live Quizzes @PrepNEXT at 9:30P.M Daily!!