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𝐏𝐡𝐚𝐫𝐌𝐃 𝐂𝐇𝐀𝐍𝐍𝐄𝐋 | 𝐑𝐱परामर्श

𝐏𝐡𝐚𝐫𝐌𝐃 𝐂𝐇𝐀𝐍𝐍𝐄𝐋 | 𝐑𝐱परामर्श

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FINEARTS-HF Trial- Fatimah Alshehri.pdf1.71 MB

Metadata in eTMF - A brief analysis.pdf3.43 KB

Clinical Data Management in clinical trials.pdf5.10 KB

CFR vs. Mortality Rate Are a disease’s "fatality rate" and "mortality rate" the same thing? No. While both measure death, they answer two very different questions, making it crucial to understand their distinction for accurate health data interpretation. Case Fatality Rate (CFR): → The Question: “How deadly is the disease for someone who is infected?” → The Calculation: (Number of deaths from the disease ÷ Number of diagnosed cases) × 100 → What it tells us: The severity of the disease. → Example: If 100 people have a disease and 10 die, CFR = 10%. Mortality Rate: → The Question: “How many people in the entire population die from this disease?” → The Calculation: (Number of deaths from the disease ÷ Total population at risk) × 100,000 → What it tells us: The overall burden and its impact on the population → Example: If those 10 deaths occur in a city of 1 million, the mortality rate = 1 per 100,000 people. A disease can have a high CFR but a low mortality rate (e.g., Rabies, Ebola). Deadly if caught, but with limited impact on the population. A disease can have a low CFR but a high mortality rate (e.g., Influenza). Most recover, but because millions are infected, the total deaths (and societal burden) are significant. Have you ever seen these two terms mixed up in a report and wondered is it describing severity (CFR) or societal burden (Mortality Rate)? Also... If you had to explain the risk of a disease to the public, which metric would you emphasize on first, is it the severity (CFR) or the burden (Mortality Rate) and why?

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Chronic Kidney Disease in Diabetes: A Clinical Practice Guideline 2025

AMSP Rounds & NABH Compliance - A Practical Checklist for Hospitals The 6th Edition of NABH Standards, has brought a paradigm shift in how hospitals approach Antimicrobial Stewardship (AMSP). What was earlier an achievement standard is now a Core Requirement under Infection Prevention & Control (IPC). That means: - AMSP is mandatory (shall), not optional. - Hospital leadership is directly accountable. - Digital dashboards, real-time reporting, and documentation are essential. To help teams align with the new NABH 6th Edition requirements, here’s a detailed AMSP Round Checklist AMSP Round Checklist : Key Domains 1️⃣ Patient Identification & Clinical Context - Patient Name, UHID, Ward/ICU, Bed No. - Primary diagnosis & comorbidities (DM, CKD, immunosuppression, etc.) - Clinical status & vitals at the time of review 2️⃣ Prescription Audit - Is an antimicrobial prescribed? (Yes/No) - Generic name used (not brand) - Indication documented clearly - Dose, route, frequency & duration correct - Stop/review date mentioned - Evidence of prophylactic vs therapeutic use 3️⃣ Appropriateness of Therapy - Empirical vs targeted therapy justified - Culture & sensitivity samples sent before starting antibiotics - Reports reviewed within 48–72 hrs - De-escalation/escalation documented as per results - Restricted antibiotic use justified & documented - Compliance with hospital antibiotic policy 4️⃣ Stewardship Indicators - IV to Oral switch considered (step-down therapy) - Narrow spectrum over broad spectrum when possible - Avoid double coverage unless absolutely indicated - Antifungal/anti-TB/antiviral therapy justified as per protocol - Duration monitored closely (no open-ended therapy) 5️⃣ Documentation & Governance - Justification forms completed for restricted antimicrobials - AMSP team recommendations recorded in patient file - Treating team acknowledgement documented - Recommendations tracked via digital dashboards - Non-compliance escalated to AMSP/Clinical Governance Committee 6️⃣ Infection Control Integration - MDR/XDR patients identified & isolation precautions followed - Hand hygiene & device care practices monitored - Source control ensured (drainage, device removal, debridement) - AMSP integrated with HAI surveillance & IPC indicators 7️⃣ Training & Competency - Prescribers, nurses & pharmacists trained in AMSP protocols - Competency assessment documented - Ongoing sensitization on NABH 6th Edition updates 8️⃣ Leadership & Accountability - Hospital leadership oversight documented in AMSP reports - Institutional dashboard tracking antimicrobial use & resistance trends - Regular review in Quality & Safety Committee meetings - Clear accountability matrix for AMSP outcomes Why this matters: -Strengthens NABH compliance -Reduces irrational antimicrobial use -Improves patient outcomes -Directly combats AMR at institutional level AMSP = Safety today, stewardship for tomorrow. hashtag#NABH hashtag#NABH6thEdition hashtag#AMSP hashtag#PatientSafety hashtag#AMR

𝐃𝐚𝐭𝐚 𝐢𝐧𝐭𝐞𝐠𝐫𝐢𝐭𝐲 isn't just a regulatory requirement; it's the foundation of patient safety and credible scientific research. 🧪🔬 The 𝗔𝗟𝗖𝗢𝗔 ++ 𝗽𝗿𝗶𝗻𝗰𝗶𝗽𝗹𝗲𝘀 provide the essential framework for ensuring data is reliable and trustworthy. Here's a quick refresher on what they stand for: 𝗔𝗟𝗖𝗢𝗔 𝘼ttributable - Who collected or altered the data? 𝙇egible - Is it readable and understandable? 𝘾ontemporaneous - Was it recorded at the time of the event? 𝙊riginal - Is it the source record or a true copy? 𝘼ccurate - Is it error-free and truthful? ++ 𝘾omplete - Is all data, including changes, accounted for? 𝘾onsistent - Is the sequence logical and uniform? 𝙀nduring - Is it recorded for the long term? 𝘼vailable - Can it be accessed for audit or inspection? 𝙏raceable - Can you reconstruct its entire history?

Matthias_Egger,_Julian_P_T_Higgins,_George_Davey_Smith_Systematic.pdf22.44 MB

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