AIMD Research

The Codman Center at the Department of Surgery, Massachusetts General Hospital, is seeking a highly motivated postdoctoral research fellow interested in pursuing innovative studies in the field of surgical outcomes research. The fellow will join a collaborative group of recognized scientists with extensive expertise in surgical outcomes research, public health, and clinical epidemiology. The research aims to enhance our understanding of surgical outcomes, and to leverage this information to develop novel intervention strategies to improve surgical quality. This position provides outstanding opportunities for continued scientific development and for contributing to pioneering research with high impact. The scientific environment at Massachusetts General Hospital, other affiliated hospitals of Harvard Medical School, and surrounding institutions such as Harvard University and Harvard T. H. Chan School of Public Health offers ample opportunity for productive collaborations. Additional Information: Please include a cover letter with your CV. To apply for this position, please email or send your CV to: Dr. David C. Chang 165 Cambridge Street Suite 403 Codman Center Department of Surgery Massachusetts General Hospital Boston MA 02114 dchang8@mgh.harvard.edu

Multiple MyelomaRaje LabThe Raje Lab in the Cancer Center at the Massachusetts General Hospital is seeking a post-PhD/MD research fellow to gain cellular mechanistic insight into clinical drugs for multiple myeloma. The group routinely uses human and mouse cell lines, mouse models, and patient samples to study the bone marrow tumor microenvironment. Candidates will have ample opportunities to acquire and develop new skills, work closely with the PI and collaborators, and communicate results to the scientific community through conference presentations and peer-reviewed publications while working in a supportive, highly collaborative, and energetic environment. State-of-the-art facilities are available within an exceptional research setting.Under the direction of the principal investigator, the applicant will independently carry out activities performing laboratory research. The prospective candidate will be involved in translational researchefforts in myeloma therapy using novel drug compounds currently under investigation. Duties include: Guide research projects through experimental design, conduct of experiments, and analysis of data; Maintain detailed documentation of the experimental work; Present data within and outside of the laboratory group at meetings and symposia; Work closely within the group and with outside collaborators; Mentor students and technicians; Maintain close communications with the PI regarding progress; Write, edit, and submit manuscripts/abstracts detailing the results of the project; Demonstrate integrity, excellence, accountability and teamwork in all interactions. Interested candidates should e-mail their curriculum vitae, along with three references and a statement of research interest attention to Dr. Noopur Raje c/o Dr. Cristina Panaroni at cristina.panaroni@MGH.HARVARD.EDU

A Cardiovascular Research Fellow position is open at Mayo Clinic in Florida. Do you thrive leading independent projects, have experience on molecular biology techniques, Stem cell research and/or extracellular vesicles, and passionate about developing biotherapeutics to treat heart lung diseases? If so, please contact: Si Pham, MD at pham.si@mayo.edu A Research Fellow at Mayo Clinic is a temporary position intended to provide training and education in research. Individuals will train in the research program of a Mayo Clinic principal investigator. Qualified individuals will demonstrate the potential for research as evidenced by their training and peer-reviewed publications and should become competitive for national research grants. Proof of English proficiency is required for J-1 Short-Term Scholars, Research Scholars, Professors, Specialists, and Student Interns sponsored by Mayo Clinic. The following is required for completeness of application: + Current curriculum vitae with bibliography + Proof of doctoral degree (copy of diploma or final transcript with English translation, if applicable) or a letter from your university's Registrar office indicating you have fulfilled all doctoral program requirements and are eligible to graduate.

Post-doctoral fellowships are available in the Ott Laboratory (ottlab.org) at the Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School - Boston, MA, United States. We are a team of dedicated scientists that use the disciplines of computational biology, chemistry, and functional genetics to define novel gene regulatory targets for cancer. Specifically, we are interested in developing early-stage chemical probes to target essential chromatin modulators and transcriptional regulators in lymphoid malignancies (leukemia, lymphoma, myeloma). Chemical biology of essential gene regulatory factors in cancer The lab is recruiting a post-doctoral molecular or chemical biologist with a significant interest in using functional, chemical and computational tools to probe the essential gene regulatory factors of lymphoid malignancies. The ideal candidate(s) will have a Ph.D., M.D., or M.D./Ph.D. in molecular biology, pharmacology, oncology, or related discipline. Familiarity with computational tools useful for genomics and epigenomics research is desirable. Available projects in the lab include understanding mechanisms of cancer cell dependency on lineage-defining gene regulatory factors and associated epigenetic machinery, high-throughput assay design and screening for novel chemical probes, functional genetic screening with gene editing technology to identify new therapeutic targets, and genome-wide chromatin structure analysis to understand gene regulatory malfunction in lymphoid malignancies. Interested candidates should send a cover letter, CV, and the contact details of at least two references directly to: Christopher Ott, PhD christopher.ott@mgh.harvard.edu

This position is for a highly motivated postdoctoral research fellow to work on an exciting project in tumor biology and tissue engineering at Johns Hopkins University at Baltimore, Maryland under PI, Dr. Mostafa Borahay, MD, PhD. Work includes an exciting project examining statins as a new treatment for uterine leiomyomas, the most common tumor of female reproductive system. It also includes building a model for uterus with the three cellular layers, muscle, stroma and epithelium using tissue engineering. Understanding the underlying pathogenesis of the tumor is an important goal. Johns Hopkins University, the institution #1 in NIH funding for more than 30 years. The lab environment provides an exceptional opportunity for state-of-the-art research for an ambitious fellow. The work will include cellular and extracellular experiments of cell cultures (both conventional and 3D) from primary & immortalized cells. It will also include tissues obtained from patients and animal models. In addition to standard cell culture, molecular biology, and histologic techniques, work will include experiments on stem cells. Work is funded by NIH grant and candidates for this position are expected to conduct research work in the current grant and preparation to apply for NIH funding. Strong publication track record as first author in reputable journals carries high weight in the selection process. Prior successful funding during doctoral work is a plus. Knowledge of complex scientific procedures and techniques; knowledge and practical experience in biophysical techniques, fundamental molecular and cellular biology and familiarity with biochemistry and cell culture, proliferation, cell death, protein science, Western Blotting, flow cytometry, RNA, DNA, sequencing, epigenetic (DNA methylation and histone modification) techniques. Candidate is expected to learn new techniques as necessary. Education: Ph.D. in Cell Biology or Molecular Biology is a requirement. Candidates with an MD degree and strong experience and publication record in molecular biology can be considered. Work Environment: Laboratory environment; requires working with human and animal cells/cell lines, blood, and or bodily fluids Department/Division: Johns Hopkins University, School of Medicine, Department of Gynecology and Obstetrics. Division of Division of Reproductive Science and Women's Health Research. To apply: Send CV including references and a cover letter/personal statement to PI: Mostafa Borahay, MD, PhD. Email: mboraha1@jhmi.edu

A Postdoctoral Fellow position is available in the laboratory of Dr. Andrew Lane at the Johns Hopkins University School of Medicine, Department of Otolaryngology - Head and Neck Surgery. We use a combination of cutting-edge interdisciplinary approaches in immunology, molecular genetics, and immunohistochemistry to investigate the interaction between the immune system and epithelial cells in health and in chronic inflammatory disease. We are particularly interested in basic mechanisms underlying chronic rhinosinusitis with polyps, including subcellular pathways impacting progenitor cell physiology, innate immune defense, and epithelial repair. At this time, we are specifically focusing on how these pathways impact SARS-CoV-2 infection, in collaboration with virologist team members. We are seeking a highly motivated individual with a PhD or MD/PhD degree in immunology, stem cell biology, molecular biology, cell biology, or related fields to join our group in a collaborative environment promoting creative scientific research and career development. The successful candidate will have a strong work ethic, excellent organizational and communication skills, and critical thinking abilities. Salary is commensurate with experience. Interested individuals should submit a letter of interest; current curriculum vitae; and the names, addresses, and phone numbers of three references to: Andrew P. Lane, MD Professor, Otolaryngology - Head and Neck Surgery Director, Division of Rhinology, Allergy, and Skull Base Surgery Johns Hopkins Outpatient Center, 6th floor 601 N. Caroline Street Baltimore, MD 21287-0910 alane3@jhmi.edu

The Laboratory of Molecular Psychiatry in Aging in the Department of Pharmacology & Experimental Therapeutics at Boston University School of Medicine (BUSM) is seeking to fill a full-time position of Postdoc Associate, requiring experimental skills and some experience of data analysis. The project is a multi-disciplinary study to use human samples, animal models and cell cultures to investigate the pathological pathway and risk factors of Alzheimer's disease. You will join a group of talented and motivated team members for this mission. The successful applicant will design experiments; implement different experimental techniques in molecular biology, immunology and cell biology investigate pathalogical process and drug targets for Alzheimer's Disease in a collaborative environment; conduct statistical analyses for the experimental results; write manuscripts; train students and clinicians for bench research; and test and utilize new software and tools for the experiments. Required degree: PhD or MD TO APPLY: PLEASE EMAIL CVs to Dr. Wendy Qiu at wqiu67@bu.edu

The Hemostasis and Thrombosis Research Fellowship at the Massachusetts General Hospital (MGH) is designed to provide an additional one to two years of mentoring and training in the laboratory study of coagulation disorders for an MD, either prior to or following completion of a fellowship in either pediatric hematology/oncology or medical hematology/oncology, or a PhD with interest in medical research. The objectives of the fellowship are to provide salary support, laboratory facilities, and mentoring in an area of hemostasis or thrombosis. The fellowship is supervised by Dr. Eric Grabowski, Director of the Cardiovascular Thrombosis Laboratory, and a pediatric hematologist/oncologist, and Dr. Larissa Bornikova, MD, a medical hematologist/oncologist. The fellowship will include an appointment in either the Department of Pediatrics or the Department of Medicine, depending on the applicant’s background. Present laboratory projects include improved diagnostic accuracy in Von Willebrand Disease through microfluidics and real-time image processing of images of platelets adhering to and aggregating upon a surrogate vessel wall in flowing blood and acquired using epifluorescence digital video-microscopy, a study of the role of the VWF propeptide in platelet adhesion/aggregation, evaluation of bleeding in women and girls with menorrhagia, localization of factor VIII and factor VIIa to platelet membranes in real-time in flowing blood, and parallel mouse and cell culture models of enterohemorrhagic hemolytic uremic syndrome as a complement and tissue factor-driven thrombotic microangiopathy. Dr. Grabowski is also the Medical Director of the Massachusetts General Hospital Comprehensive Hemophilia Treatment Center, while Dr. Bornikova is Associate Medical Director. The fellowship is supported by outstanding faculty in clinical laboratory coagulation, and medical hematology and coagulation. The MGH is a teaching hospital of the Harvard Medical School. If interested, please send your CV and a personal statement to Dr. Grabowski@ EGrabowski@MGH.Harvard.edu. Interviews via ZOOM are possible during the present COVID-19 crisis.

The Patil laboratory in the Center for Immunology and Inflammatory Diseases (CIID) at Massachusetts General Hospital and Harvard Medical School is seeking a highly motivated postdoctoral fellow to study allergen-specific B cells in the development and treatment of allergic diseases. Our lab established the first B cell multimer-based enrichment for allergen-specific B cells to study Ara h 2 specific B cells in peanut oral immunotherapy. We are seeking a PhD, MD/PhD, or MD scientist with a background in molecular biology with an interest in bioinformatics to lead follow-up studies in cohorts of food allergy, including peanut oral immunotherapy, but also eosinophilic esophagitis. In order to understand the role of allergen-specific B cells in the development of food allergies and treatment, we propose to utilize these cutting-edge technologies, unifying allergen-specific B cell studies with transcriptomics, proteomics, and functional assays to discover novel therapies for food allergy. Applicants should submit 1. a cover letter describing their previous scientific accomplishments and interests and career goals, 2. their C.V. and 3. contact information for three references via e-mail: Sarita U. Patil, MD Instructor, Harvard Medical School Principal Investigator, Center for Immunology and Inflammatory Diseases Principal Investigator, Food Allergy Center, Massachusetts General Hospital for Children Divison of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital sarita.patil@mgh.harvard.edu

School Harvard T.H. Chan School of Public Health Department/Area Epidemiology A Postdoctoral Fellow position is available in the Department of Epidemiology at the Harvard T.H. Chan School of Public Health. The position involves methodological and applied work in epidemiologic research focused on several collaborative projects. The successful candidate will have opportunities to conduct analysis of high-dimensional data, including high-throughput genomic and metabolomics data from perinatal and psychiatric epidemiologic studies. The Fellow will work closely with Assistant Professor Bizu Gelaye and his team, and will have opportunities for collaboration with a multidisciplinary research team working on studies of perinatal and psychiatric epidemiologic research. Basic Qualifications Applicants must have a doctoral degree in epidemiology, genetics, biostatistics or related field. Candidates should have a strong quantitative background, experience in programming and analysis of genetic epidemiological data, excellent written and oral communication skills; and ability to work independently and with collaborators. Contact Information Dr. Gelaye bgelaye@hsph.harvard.edu

A postdoctoral position in vascular immunology is immediately available in the laboratory of Dr. Roger Johns, MD, PhD, Dr. Johns’ lab has been continuously funded by the National Institutes of Health for over 30 years. The group focuses on the immunoregulatory and immunotherapy of cardiovascular and pulmonary diseases. Now the lab is seeking a research fellow to study the immune-vascular interaction in the pathogenesis of pulmonary hypertension COVID-19, and other lung inflammation-related pathologies. Deep experience and productivity in molecular and cell biology is a must. Experience in immunology and vascular or lung biology would be strengths. We are a dynamic, innovative laboratory of diverse interacting scientists. Focus spans transcriptional/epigenetic regulation, cell biology, animal model physiology, biomarker development, human cell and patient mechanistic investigation and development of therapeutics. Send application letter, CV and contact information of three references to Dr. Roger Johns (rajohns@jhmi.edu

This position is for a highly motivated postdoctoral research fellow to work on an exciting project in tumor biology and tissue engineering at Johns Hopkins University at Baltimore, Maryland under PI, Dr. Mostafa Borahay, MD, PhD. Work includes an exciting project examining statins as a new treatment for uterine leiomyomas, the most common tumor of female reproductive system. It also includes building a model for uterus with the three cellular layers, muscle, stroma and epithelium using tissue engineering. Understanding the underlying pathogenesis of the tumor is an important goal. Johns Hopkins University, the institution #1 in NIH funding for more than 30 years. The lab environment provides an exceptional opportunity for state-of-the-art research for an ambitious fellow. The work will include cellular and extracellular experiments of cell cultures (both conventional and 3D) from primary & immortalized cells. It will also include tissues obtained from patients and animal models. In addition to standard cell culture, molecular biology, and histologic techniques, work will include experiments on stem cells. Work is funded by NIH grant and candidates for this position are expected to conduct research work in the current grant and preparation to apply for NIH funding. Strong publication track record as first author in reputable journals carries high weight in the selection process. Prior successful funding during doctoral work is a plus. The fellow is expected to be self-motivated, organized, and team player. Responsibilities: + Critically review available literature and design research work accordingly. + Plans, conducts, and troubleshoots experiments. + Performs data analysis, prepares graphical representation of data, prepares manuscripts for publication in peer reviewed scientific journals, assists in the preparation of scientific reports for funded projects, presents research data at in-house meetings and at National and International scientific conferences. + Participates in preparation of applications for funding. + Participates on scientific collaborations both within and outside the institution as discussed with the PI. + Adopts technologies and protocols currently used in the lab and be able to research, find, and learn additional ones necessary for the work + Works as a team member with other faculty members, clinical research team, fellows, residents, and students. + Attends training and safety classes required by JHU + Completes other projects and duties as assigned. + Accurately documents experiments and results and keeps a detailed laboratory note. + Possesses good oral and written communication skills + Able to prioritize workload and manage multiple projects effectively. Required Knowledge, Skills, and Abilities: Knowledge of complex scientific procedures and techniques; knowledge and practical experience in biophysical techniques, fundamental molecular and cellular biology and familiarity with biochemistry and cell culture, proliferation, cell death, protein science, Western Blotting, flow cytometry, RNA, DNA, sequencing, epigenetic (DNA methylation and histone modification) techniques. Candidate is expected to learn new techniques as necessary. Education: Ph.D. in Cell Biology or Molecular Biology is a requirement. Candidates with an MD degree and strong experience and publication record in molecular biology can be considered. Work Environment: Laboratory environment; requires working with human and animal cells/cell lines, blood, and or bodily fluids Department/Division: Johns Hopkins University, School of Medicine, Department of Gynecology and Obstetrics. Division of Division of Reproductive Science and Women's Health Research. To apply: Send CV including references and a cover letter/personal statement to PI: Mostafa Borahay, MD, PhD. Email: mboraha1@jhmi.edu

The Neurocognitive Aging Section (NAS) at the National Institute on Aging is recruiting a postdoctoral fellow for an annually renewable appointment of up to 5 years. NAS focuses on systems neuroscience in preclinical animal models aimed at understanding the basis of both impaired and successful cognitive aging. Ongoing projects span from molecular biology and quantitative neuroanatomy to non-invasive brain stimulation and neuroimaging. Well-qualified, highly motivated candidates in any of these areas will be considered. Investigators interested in neural network approaches to successful cognitive aging and intervention are especially encouraged to apply. Successful candidates will have a strong background in systems and cognitive neuroscience, the neurobiology of memory or related area, and excellent writing skills. Applicants must have a PhD and/or MD and less than 5 years of research experience since receiving their final degree. To be considered, please forward a brief description of research accomplishments and interests, a current CV, and names of 3 professional references to: Peter R. Rapp Neurocognitive Aging Section rappp@mail.nih.gov

Post-doctoral fellowship positions are available in the Laboratory of Molecular Genetics at the National Heart, Lung, and Blood Institute (NHLBI), NIH. We are looking for curious and motivated individuals to join our lab to explore fundamental questions in mitochondria biology. The lab has been at the forefront in studying mitochondrial genetics and inheritance in fruit flies. Current and future projects are to understand the basic principles guiding the transmission of mitochondrial DNA, and to explore potential mito-nuclear communications that control mitochondrial biogenesis and mitochondrial genome maintenance. Beyond studies in Drosophila, our research horizon has expanded into mitochondrial and metabolic regulations in other model organisms including mouse and Dictyostelium. The NHLBI provides an outstanding research environment, excellent fellowship support, and ample opportunities for young scientists to launch their own independent research careers. For more information about our research and/or fellow application process, please contact me directly. Hong Xu, Ph.D. Senior Investigator and Lab Chief Laboratory of Molecular Genetics National Heart, Lung, and Blood Institute Bethesda, Maryland 20892 E-mail: hong.xu@nih.gov

Paid research opportunity in New York. Ability to work in close communication and contact with multiple physicians hospital and lab. Requirements: Must have a valid visa to be able to work in US. Apply on website https://careers-einstein.icims.com/jobs/13293/clinical-research-coordinator/job

Multiple post-doctoral research scholar positions are available at the Division of Rheumatology and Clinical Immunology, at Beth Israel Medical Deaconess Center. The successful candidate will work in a NIH-funded laboratory with access to state-of-the-art facilities that investigates cytokine regulation of inflammatory arthritis. Self-motivated scholars that demonstrate passion for research along with a comprehensive working knowledge of common laboratory techniques in immunology are encouraged to apply. Experience with murine models, flow cytometry, and molecular biology is desired. A PhD, or MD/PhD in a relevant field is required. Fluency in English, strong communications skills and the ability to work well within a team are also essential. Candidates with a background in bone/skin immunology demonstrated in their publication record will be preferred. Successful candidates will benefit from a dynamic and highly collaborative environment and the opportunity to interact with the extended scientific community HMS, and will be encouraged to present their research at international meetings. For more information about the lab and current research projects, and/or to be considered for the position, please send in a single PDF a detailed CV with methodological expertise, a list of scientific publications, and the contact details of three referees to iadamopo@bidmc.harvard.edu.