AIMD Research

The Hemostasis and Thrombosis Research Fellowship at the Massachusetts General Hospital (MGH) is designed to provide an additional one to two years of mentoring and training in the laboratory study of coagulation disorders for an MD, either prior to or following completion of a fellowship in either pediatric hematology/oncology or medical hematology/oncology, or a PhD with interest in medical research. The objectives of the fellowship are to provide salary support, laboratory facilities, and mentoring in an area of hemostasis or thrombosis. The fellowship is supervised by Dr. Eric Grabowski, Director of the Cardiovascular Thrombosis Laboratory, and a pediatric hematologist/oncologist, and Dr. Larissa Bornikova, MD, a medical hematologist/oncologist. The fellowship will include an appointment in either the Department of Pediatrics or the Department of Medicine, depending on the applicant’s background. Present laboratory projects include improved diagnostic accuracy in Von Willebrand Disease through microfluidics and real-time image processing of images of platelets adhering to and aggregating upon a surrogate vessel wall in flowing blood and acquired using epifluorescence digital video-microscopy, a study of the role of the VWF propeptide in platelet adhesion/aggregation, evaluation of bleeding in women and girls with menorrhagia, localization of factor VIII and factor VIIa to platelet membranes in real-time in flowing blood, and parallel mouse and cell culture models of enterohemorrhagic hemolytic uremic syndrome as a complement and tissue factor-driven thrombotic microangiopathy. Dr. Grabowski is also the Medical Director of the Massachusetts General Hospital Comprehensive Hemophilia Treatment Center, while Dr. Bornikova is Associate Medical Director. The fellowship is supported by outstanding faculty in clinical laboratory coagulation, and medical hematology and coagulation. The MGH is a teaching hospital of the Harvard Medical School. If interested, please send your CV and a personal statement to Dr. Grabowski: EGrabowski@MGH.Harvard.edu.

We are seeking multiple postdoctoral trainees to take on leading roles as part of the newly established Viral Epidemiology and Immunity Unit (VEIU). The VEIU is part of the Laboratory of Infectious Diseases (LID) within the National Institute of Allergy and Infectious Diseases (NIAID) at the National Institutes of Health (NIH). In the VEIU, we use a multidisciplinary approach to investigate immunological protec-tion against and susceptibility to emerging and reemerging viral diseases with the goal of informing how vaccines can be effectively and safely licensed and introduced through vaccination programs. Our research focuses on immunologically complex viral diseases with high global burden, including flaviviral diseases (such as dengue and Zika) and diseases caused by coronaviruses (including COVID-19). Postdoctoral trainees joining the VEIU will help design and implement projects, interacting directly with collaborators in the U.S. and internationally, including with experts leading longitudinal cohort studies in Nicaragua, Sri Lanka, Thailand, Ecuador, and the Philippines. Researchers in the VEIU will also be in-volved in establishing new clinical and observational studies at NIH and abroad. Candidates holding an M.D. and/or Ph.D. who are interested in joining the VEIU and have experience in one or more of the following areas of research are strongly encouraged to apply: • • B cell immunology • • RNA virus virology • • Epidemiology, biostatistics, or bioinformatics To apply, interested candidates should please email a curriculum vitae (CV), a brief statement of research interests and experience (~1 page), a publication or manuscript the candidate has written, and the names and contact information for at least two references to Dr. Leah Katzelnick ( leah.katzelnick@nih.gov ). The position is fully funded, available immediately, and may be held for up to 5 years.

Postdoc Position #Radiology at the Mesovision Laboratory Shahin Nasr, Ph. D. Assistant Professor in Radiology, Harvard Medical School Email: shahin.nasr@mgh.harvard.edu https://mesovision.martinos.org/wp-content/uploads/2021/07/Nasr_post-doc_2021.pdf

Post Doc Fellow, Department of #Pathology https://www.postdocjobs.com/posting/7081244

We are seeking a highly motivated and talented Postdoctoral Research Fellow to join Dr. Jaehong Suh's Laboratory in the Genetics and Aging Research Unit at Massachusetts General Hospital (MGH) and Harvard Medical School. Located in Boston, and known as one of the best places to work in academia, MGH offers a world-class research environment and an opportunity to work with highly talented scientists and clinicians. Research in Dr. Suh's lab focuses on the molecular genetics and pathobiology of Alzheimer's disease and related neurodegenerative diseases with the goal of identifying novel therapeutic targets. (https://www.mghmind.org/faculty/suh-jaehong-phd). Successful candidates should have strong background either in neurobiology, molecular genetics, or biochemistry, evidenced by a record of scientific publications. Experience with rodent model is preferred, but not required. The hired candidate will work on NIH- and foundation-funded projects or on emerging new projects in Dr. Suh's lab. Interested candidates should send their CV, contact information of three references and a brief description of interests to: suh.jaehong@mgh.harvard.edu

A three-year Post-Doctoral Fellowship in Nuclear Medical Physics is available at Department of Radiology of the University of Massachusetts. The successful candidate will participate in ongoing research in SPECT imaging, reconstruction, motion estimation and correction, and applications of deep learning. To apply send an e-mail to: Michael.King@umassmed.edu

The Yale University PET Center has an opening at the post-doctoral level to work on research involving quantitative PET imaging data analysis and development of integrative analyses for multimodal (PET and MRI) neuroimaging data under the direction of Dr. Ansel Hillmer. If interested please email: ansel.hillmer@yale.edu

Postdoctoral fellowship at Mass General Hospital. We are seeking motivated candidates interested in development of novel positron emission tomography (PET) radiotheranostics using nanobodies, with skills in small animal PET imaging, basic radiometal labeling, and PET imaging analysis. Candidates should have a PhD or MD degree. If interested please email: Dr. Umar Mahmood umahmood@mgh.harvard.edu

Epigenetics and Inflammatory Laboratory in the Department of Nephrology & Hypertension at Mayo Clinic in Rochester, MN under** Dr. Xiaogang Li . The lab mainly focuses on understanding molecular mechanisms and discovery treatment for autosomal dominant polycystic kidney disease (ADPKD) and other kidney diseases. The lab uses multidisciplinary approaches including all kinds of genetic and epigenetic techniques, Immunostaining, and biochemistry in a variety of transgenic and knockout mice. The long-term goal of the lab is to identify and manipulate specific targets in cystic kidneys that complement existing strategies. Candidates with expertise in biochemistry and molecular biology, in vivo mouse studies, or prior experience in inflammation are encouraged to apply. • *Interested applicants should please send a cover letter with research interests, curriculum vitae, and contact information of three referees to Dr. Xiaogang Li at: Li.Xiaogang@mayo.edu

The Laboratory of Molecular Psychiatry in Aging in the Department of Pharmacology & Experimental Therapeutics at Boston University School of Medicine (BUSM) is seeking to fill a full-time position of Postdoc Associate, requiring experimental skills and some experience of data analysis. The project is a multi-disciplinary study to use human samples, animal models and cell cultures to investigate the pathological pathway and risk factors of Alzheimer's disease. You will join a group of talented and motivated team members for this mission. The successful applicant will design experiments; implement different experimental techniques in molecular biology, immunology and cell biology investigate pathalogical process and drug targets for Alzheimer's Disease in a collaborative environment; conduct statistical analyses for the experimental results; write manuscripts; train students and clinicians for bench research; and test and utilize new software and tools for the experiments. Required degree: PhD or MD TO APPLY: PLEASE EMAIL CVs to Dr. Wendy Qiu at wqiu67@bu.edu

A postdoctoral research fellow position is available in the Laboratory for Surgical and Metabolic Research at the Department of Surgery, Brigham and Women’s Hospital, Harvard Medical School. Research focus will include investigation of the mechanism of bariatric surgery, therapeutic targets to combat obesity related type 2 diabetes mellitus, and investigations of gastrointestinal metabolism and immunity. The successful candidate will work with a highly collaborative team of investigators and will be exposed to a wide array of state-of-the-art technologies, including cellular and molecular biology, metabolism, immunology, proteomics and innovative surgery animal models. There will be many opportunities to benefit from the rich and diverse scientific environment of Harvard Medical School.  Working Conditions: The laboratory environment is a BL2 (Biosafety Level 2) environment. Human tissue and animal tissue (bloodborne pathogens) are present at all times. Universal safety precautions must be adhered to and followed at all times. Laboratory also uses radioisotopes for some experimentation however exposure is of minimal risk. Chemical exposure is present at all times. Please send your CV, an outline of your research interests, and names and addresses of three references to Dr. Eric Sheu at esheu@bwh.harvard.edu

Job description:The Codman Center at the Department of Surgery, Massachusetts General Hospital, is seeking a highly motivated postdoctoral research fellow interested in pursuing innovative studies in the field of surgical outcomes research. The fellow will join a collaborative group of recognized scientists with extensive expertise in surgical outcomes research, public health, and clinical epidemiology. The research aims to enhance our understanding of surgical outcomes, and to leverage this information to develop novel intervention strategies to improve surgical quality. This position provides outstanding opportunities for continued scientific development and for contributing to pioneering research with high impact. The scientific environment at Massachusetts General Hospital, other affiliated hospitals of Harvard Medical School, and surrounding institutions such as Harvard University and Harvard T. H. Chan School of Public Health offers ample opportunity for productive collaborations.Additional Information:Please include a cover letter with your CV.To apply for this position, please email or send your CV to:Dr. David C. Chang SurgeryMassachusetts General dchang8@mgh.harvard.edu

Available Position: Postdoctoral Research Fellow in eye research Institution: Boston Children’s Hospital and Harvard Medical School, Boston, MA, USA Position Description: An NIH-funded postdoctoral research fellow position is available immediately in Dr. Jing Chen’s lab in the department of ophthalmology at Boston Children’s Hospital and Harvard Medical School to study the molecular basis of eye diseases. Successful candidate will perform research in animal models of eye diseases using both genetic and pharmacological approaches to study the underlying molecular mechanisms and identify potential therapeutics for vascular and neuronal degenerative eye diseases including retinopathy of prematurity, diabetic retinopathy and age-related macular degeneration. Current projects in the lab include: 1) Wnt signaling-mediated blood-retinal barrier control and vascular leakage; 2) nuclear receptor-mediated retinal pigment epithelium oxidative damage and degeneration in dry age-related macular degeneration; 3) chronic ocular inflammation in retinal aging. Research fellow will be trained with various techniques including in vivo retinal fundus and OCT imaging, single cell RNA sequencing, confocal imaging, and other skills needed for eye research. Job responsibility: the research fellow will assist PI in designing experiments, performing molecular, cellular and imaging analysis in the projects, presenting findings in local seminars and national professional meetings, writing manuscripts for peer review, and assisting with research grant writing and reporting. Detailed information of the lab’s research can be found at: http://www.childrenshospital.org/research/researchers/c/jing-chen Requirement: • Ph.D. in biomedical science, cell biology, molecular biology, visual science or related fields; or MD in ophthalmology or relevant specialty; with 0-2 years of experience. • Track record of publishing in scientific journals; • Experience in wet bench lab work, including small animal (rodent) research work and cell culture. Interested candidate please send a cover letter detailing your research interest and career goals, and a CV with names of three references to: Jing Chen, PhD, Associate Professor of Ophthalmology, Boston Children’s Hospital and Harvard Medical School, chenlab.boston@gmail.com

Postdoctoral Fellow - Genome Editing and Small Molecule Therapy Duke University, Durham, NC Salary commensurate with experience, includes excellent benefits. Postdoctoral position available immediately for research on genome editing in rare genetic diseases. Genome editing with adeno-associated virus vectors is a major focus of the laboratory. The project will include in vivo genome editing to treat glycogen storage disease (GSD), either GSD type Ia or type II (Pompe disease). A second focus is to develop small molecules to stimulate autophagy and reverse the abnormalities of autophagy in GSDs. New drug therapy for GSDs will have implications for the treatment of more common conditions, including non-alcoholic fatty liver disease and diabetic nephropathy. Representative publications describe the scope of this project [1-6]. Duke University features outstanding clinical and scientific resources with opportunities for local and international collaboration. This position will support an active collaboration with established genome editing, autophagy, and virology research groups. Candidates with molecular biology experience, and familiarity with viral vectors, immunology, and/or biochemistry are encouraged to apply. Ph.D. and/or M.D. required. The position is located in Dwight Koeberl's laboratory in the Department of Pediatrics/Division of Medical Genetics, and the Department of Molecular Genetics and Microbiology at Duke University School of Medicine. Website: https://scholars.duke.edu/display/per3329362 Interested candidates should submit their electronic application to dwight.koeberl@duke.edu that should include: (1) the names of 3 references, and (2) an updated CV.

A Postdoctoral Fellow position is available in the laboratory of Dr. Andrew Lane at the Johns Hopkins University School of Medicine, Department of Otolaryngology - Head and Neck Surgery. We use a combination of cutting-edge interdisciplinary approaches in immunology, molecular genetics, and immunohistochemistry to investigate the interaction between the immune system and epithelial cells in health and in chronic inflammatory disease. We are particularly interested in basic mechanisms underlying chronic rhinosinusitis with polyps, including subcellular pathways impacting progenitor cell physiology, innate immune defense, and epithelial repair. At this time, we are specifically focusing on how these pathways impact SARS-CoV-2 infection, in collaboration with virologist team members. We are seeking a highly motivated individual with a PhD or MD/PhD degree in immunology, stem cell biology, molecular biology, cell biology, or related fields to join our group in a collaborative environment promoting creative scientific research and career development. The successful candidate will have a strong work ethic, excellent organizational and communication skills, and critical thinking abilities. Salary is commensurate with experience. Interested individuals should submit a letter of interest; current curriculum vitae; and the names, addresses, and phone numbers of three references to: Andrew P. Lane, MD Professor, Otolaryngology - Head and Neck Surgery Director, Division of Rhinology, Allergy, and Skull Base Surgery Johns Hopkins Outpatient Center, 6th floor 601 N. Caroline Street Baltimore, MD 21287-0910 alane3@jhmi.edu

New postdoctoral positions are open in a cancer research laboratory located within The University of Texas MD Anderson Cancer Center. The lab currently studies ferroptosis and metabolism in cancer [see our publications Nature 2021, Nature Communications 2021, Nature Cell Biology 2020 (X 2), Cell Research 2020, Cancer Research 2020, Nature Cell Biology 2018, Nature Communications, 2017; PNAS, 2017; Nature Cell Biology 2016; Nature. 2010; see link below for complete publication list https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/47340098/?sort=date&direction=descending]. The lab is well funded to support various projects related to the research topics described above.The putative postdoc researcher will have the opportunities to work on various projects studying the roles of ferroptosis (a form of regulated cell death induced by lipid peroxidation) in tumor suppression and cancer therapy (please visit our lab webpage for detailed introduction on research projects https://www.mdanderson.org/research/departments-labs-institutes/labs/gan-laboratory.html). Qualified candidates should have strong background in one or more of the following areas: molecular/cell biology, biochemistry, metabolism, cancer genetics, or using Mass Spectrometry-related technologies to study metabolism. We prefer candidates who are about to graduate with PhD or MD/PhD degree, or have graduated within the last 12 months. A track record of excellent first author publication during PhD training is essential. The pay scale follows NIH guidelines ($53,760 for fresh PhD with adjustment for more senior candidates).MD Anderson is the number one cancer center in cancer care in the United States by the U.S. News and World Report’s “America’s Best Hospitals” survey. It ranks 1st in the number of awarded grants from National Cancer Institute. It offers active graduate and postdoctoral training programs and the unmatched scientific environment of the Texas Medical Center, the world’s largest biomedical center. MD Anderson is an equal opportunity/affirmative action employer. Houston is the 4th largest city in the United States with relatively low living cost and no state or city income tax. The interested candidates should send a CV to bgan@mdanderson.org.