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69. Explanation
A) (b) Rathke pouch
• The anterior pituitary and intermediate lobe of pituitary
develops from Rathke’s pouch, which is initially derived from the anterior neural ridge, adjacent to cells in the
neural plate.
• Neural plate contributes to ventral diencephalon.
• Posterior lobe of pituitary develops from the infundibulum, an evagination of the ventral diencephalon.
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68. Explanation
A)(b) Para-axial mesenchyme
• The axial skeleton, vertebrae and ribs are derived from paraxial mesenchyme
• The skull is derived from paraxial mesenchyme and neural crest mesenchyme
• The skeletal elements in the limbs are derived from somatopleuric mesenchyme, which forms the limb buds.
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67. Explanation
A) Lesch Nyhan Syndrome
• XLR condition
• Occurs due to complete deficiency of HGPRTase enzyme → accumulation of purine
• Degradation of purine → Increased uric acid
• The syndrome is characterized by hyperuricemia, nephrolithiasis, obstructive uropathy, self-mutilative
behaviour, choreoathetosis, spasticity, and mental retardation.
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66. Explanation
A) • Fatty acids with an odd number of carbon atoms are oxidized by the pathway of beta-oxidation, producing
acetyl-CoA, until a three-carbon (propionyl-CoA) residue remains.
• Odd-chain fatty acid is the only part of a fatty acid that is glucogenic.
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67. Which of the following X-linked condition presents as urolithiasis with gouty arthritis:
66. Beta oxidation of odd chain fatty acid produces acetyl CoA and_____?
64. Explanation
A) Hyaline cartilage is blue colored while elastic cartilage is
yellow and fibrocartilage is white.
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65. Explanation
A) Tyson glands are located on external surface of prepuce and are holocrine glands.Holocrine glands are characterised by disentigration of
entire cell which discharges its secretions.
• The holocrine glands are found everywhere except palms
and soles.
• Sebaceous glands are usually associated with hair follicles
except in following locations
Eyelids: Glands of zeis and meibomian glands
Nipple and areola: Montgomery tubercle
Tyson glands: Prepuce
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