Rheumatology Updates

Local reasoning large language models for privacy‐preserving identification of systemic lupus erythematosus https://acrjournals.onlinelibrary.wiley.com/doi/10.1002/art.70330?af=R Arthritis &Rheumatology, EarlyView.

Updated COVID‐19 Vaccines and Health Outcomes in Patients With Autoimmune Rheumatic Conditions https://acrjournals.onlinelibrary.wiley.com/doi/10.1002/art.70290?af=R Arthritis &Rheumatology, EarlyView.

String of pearls Embellishing Lupus https://acrjournals.onlinelibrary.wiley.com/doi/10.1002/art.70328?af=R Arthritis &Rheumatology, Accepted Article.

Single‐cell RNA sequencing of peripheral blood defines two immunological subtypes of Sjögren's disease distinguished by anti‐SSA antibodies and aberrant B cell populations https://acrjournals.onlinelibrary.wiley.com/doi/10.1002/art.70320?af=R Arthritis &Rheumatology, Accepted Article.

CD248/Endosialin regulates synovial fibroblast state to control coupling of inflammation and bone damage in murine models of immune‐mediated inflammatory arthritis and ageing https://acrjournals.onlinelibrary.wiley.com/doi/10.1002/art.70327?af=R Arthritis &Rheumatology, Accepted Article.

Macrophages in fibrin-rich lining niche shape the rheumatoid pannus https://www.nature.com/articles/s41584-026-01428-9

CD248: Guardian of Synovial Fibroblast Fate https://acrjournals.onlinelibrary.wiley.com/doi/10.1002/art.70323?af=R Arthritis &Rheumatology, Accepted Article.

DNMT3a loss in T cells attenuates experimental arthritis: implications for interpreting human clonal hematopoiesis of indeterminate potential–rheumatoid arthritis associations: comment on the article by Shen et al https://acrjournals.onlinelibrary.wiley.com/doi/10.1002/art.70308?af=R Arthritis &Rheumatology, EarlyView.

CASTOR1 regulates humoral immune responses and contributes to the pathogenesis of systemic lupus erythematosus https://acrjournals.onlinelibrary.wiley.com/doi/10.1002/art.70314?af=R Arthritis &Rheumatology, Accepted Article.

Antibiotic-induced loss of gut SCFAs exacerbates alphavirus arthritis https://www.nature.com/articles/s41584-026-01435-w

Vaccination considerations in autoimmune rheumatic diseases https://www.nature.com/articles/s41584-026-01427-w

Early synovial regulatory T cell engagement in posttraumatic osteoarthritis https://acrjournals.onlinelibrary.wiley.com/doi/10.1002/art.70321?af=R Arthritis &Rheumatology, Accepted Article.

CDC42–pyrin interactions promote inflammasome activation and autoinflammatory disease https://www.nature.com/articles/s41584-026-01433-y

Down‐Regulated Fli1 in Scleroderma Myeloid Cells Contributes to Cardiac Fibrosis Via a Galectin‐3/mTOR Dependent Pathway https://acrjournals.onlinelibrary.wiley.com/doi/10.1002/art.70299?af=R Arthritis &Rheumatology, EarlyView.

Time to rethink clinical trial design in Sjögren disease https://www.nature.com/articles/s41584-026-01429-8

<i>ADAR1</i> variants define an interferon-related subtype of psoriatic disease https://www.nature.com/articles/s41584-026-01431-0

Cancer in systemic sclerosis: clinical associations and prognostic impact from the EUSTAR registry https://acrjournals.onlinelibrary.wiley.com/doi/10.1002/art.70303?af=R Arthritis &Rheumatology, Accepted Article.

Development and temporal validation of AI‐enhanced HEp‐2 indirect immunofluorescence image analysis for specific autoantibody prediction in systemic autoimmune rheumatic diseases https://acrjournals.onlinelibrary.wiley.com/doi/10.1002/art.70312?af=R Arthritis &Rheumatology, Accepted Article.

AI in the Exam Room: Its Potential to Transform the Healing Relationship in Rheumatology and Beyond https://acrjournals.onlinelibrary.wiley.com/doi/10.1002/art.70313?af=R Arthritis &Rheumatology, Accepted Article.