COTAR | مرکز تحقیقات میانرشتهای کاربردی ارتوپدی
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مرکز تحقیقات میانرشتهای کاربردی ارتوپدی وابسته به دانشگاه علوم پزشکی تهران Center for Orthopedic Trans-Disciplinary Applied Research (COTAR) ⬅️ Previously, Research Center for Neural Repair (RCNR) 🆔 @COTAR_Support 🌐 cotar.tums.ac.ir
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Channel Posts
✳️ کارگاه آنلاین «آمار و SPSS مقدماتی»
♨️ از سری کارگاههای توانمندسازی پژوهشگران
✏️ با تدریس فرشته عیدی، دانشجوی دکتری آمار زیستی
🗓 پنجشنبهها ۱ الی ۲۲ شهریور ۱۴۰۳
⏰ ساعت ۱۶ الی ۲۰
🎁 کد تخفیف ۲۵ درصدی:
cotar_tums
📄 همراه با صدور گواهی شرکت در کارگاه
📔 مشاهده طرح درس دوره
🔻 ثبتنام در کارگاه:
cotar.tums.ac.ir/workshop
❓ پرسشوپاسخ: @COTAR_Support
🆔 @COTAR_TUMS
🆔 @src_tmu | @MIT_TUMS | @interdisciplinary_surgery
🆔 @SSRC_News| 2 | سلام!
🔹انجمن دانشجویی میان رشتهای علوم جراحی، زیر نظر مرکز رشد استعدادهای درخشان دانشگاه علوم پزشکی تهران شروع به کار میکند.
🔸این انجمن تحت حمایت مرکز تحقیقات میان رشتهای ارتوپدی (کوتار) و استاد نبیان عزیز فعالیت دارد.
🔺اگر به فعالیتهای پژوهشی علاقمندید یا قصد دارید جراح نوآوری بشید با ما همراه باشید..
@interdisciplinary_surgery | 112 |
| 3 |  ✳️ کارگاه آنلاین «پرسشنامه تحقیقاتی»
♨️ از سری کارگاههای توانمندسازی پژوهشگران
✏️ با تدریس فرشته عیدی، دانشجوی دکتری آمار زیستی
🗓 چهارشنبه ۱۰ مرداد ۱۴۰۳
⏰ ساعت ۱۶ الی ۱۹
🎁 کد تخفیف ۵۰ درصدی: cotar_tums
📄 همراه با صدور گواهی شرکت در کارگاه
🔻 ثبتنام در کارگاه:
cotar.tums.ac.ir/workshop
❓ پرسشوپاسخ: @COTAR_Support
🆔 @COTAR_TUMS
🆔 @MIT_TUMS
🆔 @SSRC_News | 3 869 |
| 4 | ❇️ انتشار #مقاله جدید با وابستگی کوتار
💠 Global research trends on systemic lupus erythematosus and thyroid cancers (1964-2023): A scientometric and visualized study
👥 Hediyeh Alemi, Naghmeh Khavandgar, Iman Menbari Oskouie, Heydar Ali Mardani-Fard, Tahereh Rostami, Azadeh AleTaha, Niloofar Peykari, Majid Alikhani, Sayed Mahmoud Sajjadi-Jazi, Amir Kasaeian*, Shirin Djalalinia, Akbar Soltani
📔 Medicine (Q2)
🗓 June 2024
🗂 Review
📄 Abstract: Over the past 3 decades numerous studies have reported an association between systemic lupus erythematosus (SLE) and thyroid cancers. However, there has been no scientometric analysis in this area of research. To perform a comprehensive scientometric analysis of the global literature published on the association between SLE and thyroid cancers. The data on publications within thyroid cancers in SLE patients were retrieved from the Scopus database using a defined search strategy from its first publication in 1964 to 2023. To conduct a collaboration mapping analysis among keywords, authors, journals, and territories, VOSviewer was utilized. Our final research resulted in 246 scientific publications with 8072 citations, which were published in 198 journals affiliated to 48 countries. A global upward trend has been observed in the last 20 years, with the highest number of publications in the year 2022 (n = 28; 11.4%). The United States led the global productivity ranking with 74 publications (30.1%), followed by China with 25 publications (10.2%). The most popular journals in this field were "Arthritis Research and Therapy" and "Frontiers in Endocrinology," while the most co-cited journal was "Autoimmunity Reviews." The top 3 most prolific authors were Bernatsky, S., Clarke, A.E., and Ramsey-Goldman, R with 9 publications each. This first scientometric study comprehensively offered an overview of the status of thyroid cancers in SLE patients, assessing scholarly productivity in this domain over a period of 50 years.
🔗 https://dx.doi.org/10.1097/MD.0000000000038511
📢 در صورتی که مقالهای با وابستگی کوتار چاپ کردهاید، لطفا با ارسال آن برای @COTAR_Support ما را آگاه کنید.
🆔 @COTAR_TUMS | 478 |
| 5 |  📍پروژهی RRE مرکز پژوهشهای دانشگاه علوم پزشکی تهران
🟩 در این پروژه که در فیلدهای نورولوژی، رادیولوژی، قلب، گوارش، ارتوپدی، علوم آزمایشگاهی و بهداشت طراحی شده، شما به کمک آموزش همزمان پروژهی خود را آغاز خواهید کرد. در هر یک از این فیلدها، موضوعات نوین از جمله هوش مصنوعی، مطالعات مولکولی و سلولی و نیز تکنولوژیهای جدید مورد مطالعه قرار خواهند گرفت.
🟩 در این راستا، منتورهایی که با وسواس برای این پروژه انتخاب شدهاند، از زمان نوشتن پروپوزال تا زمان سابمیت مقاله و نیز برای کمک در نوشتن ریویوی همزمان همراه شما خواهند بود.
🗓 ددلاین ثبت نام: ۱۱ تیر [این ددلاین تمدید نخواهد شد.]
برای کسب اطلاعات بیشتر و ثبت نام به این لینک مراجعه کنید.
🆔️ @SSRC_News | 366 |
| 6 |  🎗 #افتخار جدید: کسب جایزه دکتر پرویزی (انجمن جراحان ارتوپدی ایران) توسط دکتر رامین شایان
♨️ بدین وسیله کسب جایزه دکتر پرویزی توسط جناب آقای دکتر رامین شایان، پژوهشگر محترم مرکز تحقیقات میانرشتهای کاربردی ارتوپدی، را به خانواده کوتار تبریک عرض مینماییم. این جایزه هر ساله از طرف انجمن جراحان ارتوپدی ایران به برترین پایاننامه رزیدنتی کشور تعلق میگیرد.
🌱 به امید حرکت به سمت هدف اصلی پژوهشها. | 572 |
| 7 | ❇️ انتشار #مقاله جدید با وابستگی کوتار
💠 Proximal femoral varus osteotomy for Legg–Calvé–Perthes disease: Do age and lateral pillar classifications influence short-to-mid-term clinical and radiological outcomes?
👥 Nima Hoseini-Zare, Peyman Mirghaderi, Brice Ilharreborde, Kiarash Roustai-Geraylow, Alireza Moharrami, Taghi Baghdadi, Seyed Hadi Kalantar, Mohammad Hossein Nabian
📔 Orthopaedics & Traumatology: Surgery & Research (Q1)
🗓 May 2024
🗂 Original research
📄 Abstract: Proximal femoral varus osteotomy (FVO) is one of the most used treatment methods with acceptable outcomes for Legg–Calvé–Perthes disease (LCPD). We aimed to investigate the influence of age at disease onset and the Lateral Pillar classification on clinical and radiological outcomes of FVO surgery LCPD patients between 6–12 years of age. Proximal FVO surgery in the early fragmentation phase of LCPD patients led to acceptable clinical and radiographic outcomes in a 3-year follow-up, regardless of preoperative age and Herring type. Fifty patients with LCPD (Herring groups B, B/C, and C) who underwent FVO were retrospectively reviewed. We evaluated radiological [center-edge angle, extrusion index, epiphyseal index, acetabular index, articulo-trochanteric distance (ATD)] and clinical [hip abduction range of motion (ROM), Trendelenburg sign, pain, and Harris hip score (HHS)] outcomes with a follow-up of 37.3 ± 10.5 months (range: 24–180 months). Finally, the overall treatment outcome was assessed using the Stulberg classification. The ROC curve analysis did not reveal any significant relationship between age and clinical or radiological outcomes, and there was no predictable age cut-off for surgical outcomes (p = 0.13). No significant difference was found in Stulberg classification at the follow-up between patients with type B, B/C, and C of the lateral pillar (p > 0.05). Our results demonstrated that open-wedge proximal FVO surgery in the early fragmentation phase of LCPD patients led to acceptable clinical and radiographic outcomes in a 3-year follow-up. Each sample of our study was very small and a lot of variables were measured, making this result not adequately strong enough to draw a robust conclusion. However, FVO surgery remains a possible suggestion for patients in the early fragmentation phase, and age and lateral pillar type may not be limiting factors.
🔗 https://doi.org/10.1016/j.otsr.2024.103909
📢 در صورتی که مقالهای با وابستگی کوتار چاپ کردهاید، لطفا با ارسال آن برای @COTAR_Support ما را آگاه کنید.
🆔 @COTAR_TUMS | 431 |
| 8 | ❇️ انتشار #مقاله جدید با وابستگی کوتار
💠 Biomechanical Study of Using Patient-Specific Diaphyseal Femoral Cone in Revision Total Knee Arthroplasty (rTKA)
👥 Reza Nourishirazi, Ghazaleh Moradkhani, Arash SharafatVaziri, Hamidreza Nematy, Ramin Shayan-moghadam, Morad Karimpour
📔 Journal of Orthopaedics (Q3)
🗓 June 2024
🗂 Original research
📄 Abstract: The primary objective of revision total knee surgery is to achieve solid bone fixation. Generally, this could be accomplished using sleeves and long stems, which require substantial remaining bone stock and may increase the risk of stem tip pain. An alternative approach involves the use of customized diaphyseal cones, which can preserve the integrity of the bone canal. This study evaluates the impact of employing femoral diaphyseal cones with various stem lengths on stress distribution and relative motion. CT scan data from five patients were used to generate the 3D model of the femur, cement, customized stems, and cones, along with assigning patient-specific material for each candidate’s femur. Three different stem lengths, both with and without the customized cone, were assessed under three gait loading conditions to compare the resulting Von Mises stress distribution and relative motion. Analysis indicated that the use of customized femoral cones moderately increases stress distribution values up to 30 % while significantly reducing relative motion at the femoral canal-cone interface by nearly 60 %. The presence of the cone did not significantly alter relative motion with varying stem lengths, although stem length variation without a cone substantially affected these values. Incorporating cones alongside stems enhances metaphyseal fixation, reduces stress shielding, potentially allowing for the use of shorter stems. Furthermore, cones promote osseointegration by minimizing relative motion, ultimately improving prosthetic stability.
🔗 https://doi.org/10.1016/j.jor.2024.06.002
📢 در صورتی که مقالهای با وابستگی کوتار چاپ کردهاید، لطفا با ارسال آن برای @COTAR_Support ما را آگاه کنید.
🆔 @COTAR_TUMS | 331 |
| 9 |  📣 کارگاه مبانی مقالهنویسی در علوم پزشکی
🔄 جلسه سوم (هدیه): چگونه یک مقاله را اصلاح و داوری کنیم؟
👨🏫 با تدریس دکتر شاهین آخوندزاده، استاد دانشگاه علوم پزشکی تهران و پژوهشگر ۱٪ پر استناد برتر دنیا
📆 پنجشنبه، ۲۴ خرداد ماه
⏰ ساعت ۸ الی ۱۲
🌐 به صورت مجازی در بستر اسکایروم
© همراه با ارائه گواهینامه حضور در کارگاه
🔖 فیلم جلسات برگزار شده به صورت ضبطشده در اختیار ثبتنامکنندگان قرار میگیرد.
♨️ کد تخفیف ۳۰ درصدی:
cotar_tums
🔽 ثبتنام و اطلاعات بیشتر:
cotar.tums.ac.ir/sww
🆔 @Orthopedic_Association
🆔 @COTAR_TUMS | 336 |
| 10 | ❇️ انتشار #مقاله جدید با وابستگی کوتار
💠 Postural Control Measures After Lateral Ankle Sprain While Wearing Ankle Orthoses: A Systematic Review
👥 Mahmood Bahramizadeh, Hanieh Khaliliyan*, Arash Sharafatvaziri, Ebrahim Sadeghi-Demneh, Lukasz Szarpak, Michal Pruc, Aanuoluwapo Adeyimika Afolabi, Francesco Chirico
📔 Iranian Rehabilitation Journal (Q4)
🗓 March 2024
🗂 Review
📄 Abstract: Ankle orthoses are one of the interventions used to prevent first and repeated lateral ankle sprains. We conducted this systematic review of the literature to investigate the effect of ankle orthoses on postural control in individuals with acute, chronic, or functional ankle sprains. Three electronic databases (Scopus, PubMed, and Web of Science) were searched for experimental studies using predefined keywords. We used the PRISMA method to select articles. Initially, the articles were examined for inclusion criteria and then assessed for their quality based on the physiotherapy evidence database scale. In the initial search, we retrieved 156 articles. After following the steps of the PRISMA flowchart and reviewing the entire text, only 14 reports met the inclusion criteria of this study. We extracted data from population, intervention, and outcome measures. Overall, ankle orthoses were effective in improving the static postural control of patients with lateral ankle sprains; however, the dynamic postural control results were unclear. Since most people who experience lateral ankle sprains have both functional and mechanical instability, ankle orthoses may affect both types of instability and thereby improve postural control.
🔗 http://dx.doi.org/10.32598/irj.22.1.1719.3
📢 در صورتی که مقالهای با وابستگی کوتار چاپ کردهاید، لطفا با ارسال آن برای @COTAR_Support ما را آگاه کنید.
🆔 @COTAR_TUMS | 406 |
| 11 | 📣 کارگاه مبانی مقالهنویسی در علوم پزشکی
🔄 جلسه سوم (هدیه): چگونه یک مقاله را اصلاح و داوری کنیم؟
👨🏫 با تدریس دکتر شاهین آخوندزاده، استاد دانشگاه علوم پزشکی تهران و پژوهشگر ۱٪ پر استناد برتر دنیا
📆 پنجشنبه، ۲۴ خرداد ماه
⏰ ساعت ۸ الی ۱۲
🌐 به صورت مجازی در بستر اسکایروم
© همراه با ارائه گواهینامه حضور در کارگاه
🔖 فیلم جلسات برگزار شده به صورت ضبطشده در اختیار ثبتنامکنندگان قرار میگیرد.
♨️ کد تخفیف ۳۰ درصدی:
cotar_tums
🔽 ثبتنام و اطلاعات بیشتر:
cotar.tums.ac.ir/sww
🆔 @Orthopedic_Association
🆔 @COTAR_TUMS | 644 |
| 12 | ❇️ انتشار #مقاله جدید با وابستگی کوتار
💠 Comparative Study of External Fixators With Different Spatial Configurations in the Damage Control Surgery of Comminuted Diaphyseal Fracture
👥 Yousof Mohandes*, Mohammad Tahami, Amir R. Askari
📔 Iranian Journal of Science and Technology, Transactions of Mechanical Engineering (Q2)
🗓 May 2024
🗂 Original research
📄 Abstract: Fractures in the lower extremities are sometimes accompanied by severe damage, so definitive treatments with extensive surgical exposure are impractical. Extensive traumatization and swelling of surrounding tissue often dictate the use of external fixators as a temporary treatment for immediate stabilization of compound fractures. External fixation offers a variety of possible spatial configurations. Adequate fracture stabilization demands a good understanding of the stiffness, strength, sustainability, and tilting of external fixators of different frames. An improper frame can result in nonunion, malunion, delayed healing, and bone re-fracture, some of which are indications for revision surgery. This study employs a numerical approach to assess the stiffness, stress distribution, pin loosening, and interfragmentary displacement in different configurations of external fixators applied to a comminuted fracture in the diaphyseal region of the tibia. Unilateral fixators with single and double rods, bilateral, biplanar, and triangular frames with and without end cross-links are different configurations examined in-silico. Results show that the triangular frame with cross-links exhibits the stiffest, strongest, and most sustainable construct in axial, bending, and torsion modes. Except for the torsion mode, adding the end cross-links does little to increase the stiffness and strength of biplanar and triangular frames. Moreover, doubling the rod considerably improves construct stiffness and strength under axial compression load while appearing to be less superior in torsional stiffness and pin loosening. Furthermore, the bilateral frame demonstrates the most uniform displacement across the fracture gap. The results of this study could be used for preoperative planning of diaphyseal fracture management with external fixators.
🔗 https://doi.org/10.1007/s40997-024-00777-8
📢 در صورتی که مقالهای با وابستگی کوتار چاپ کردهاید، لطفا با ارسال آن برای @COTAR_Support ما را آگاه کنید.
🆔 @COTAR_TUMS | 402 |
| 13 | ❇️ انتشار #مقاله جدید با وابستگی کوتار
💠 Hypertrophic synovial plica in the lateral side of the knee - A case report: Case report and literature review
👥 Arash Sherafatvaziri, Fardis Vosoughi, Alireza Mirzamohamadi, Erfan Babaei Nejad, Ramin Shayan-Moghadam*
📔 International Journal of Surgery Case Reports (Q3)
🗓 June 2024
🗂 Case report
📄 Abstract: Plicae or synovial folds can be detected in different joints, especially around the knee. Synovial plicae pathologies are rare conditions with difficulty in diagnosis because of various symptoms overlapping with other diseases. We reported a rare case of symptomatic hypertrophic synovial plica in the lateral side of the knee in a 12-year-old boy following a traumatic event almost two years before the surgery. The diagnosis and treatment were conducted by knee arthroscopy, and follow-up of the patients showed significant improvements with no pain or range of motion restrictions. The reported case had a significantly lower age of presentations compared to most previously reported cases, and he was diagnosed with lateral knee hypertrophic plicae, while medial knee hypertrophic plicae are more commonly reported, which is considered rare findings. Contrary to previous studies of lateral plica, our case had a history of significant direct trauma, and he was not a professional athlete. Furthermore, based on evidence, hypertrophic synovial plicae are mostly asymptomatic, but in our case, there was a pain in his knee that worsened in flexion. Physicians should consider the possibility of synovial hypertrophic plicae, especially in younger patients with histories of direct traumatic events.
🔗 https://doi.org/10.1016/j.ijscr.2024.109705
📢 در صورتی که مقالهای با وابستگی کوتار چاپ کردهاید، لطفا با ارسال آن برای @COTAR_Support ما را آگاه کنید.
🆔 @COTAR_TUMS | 385 |
| 14 | ❇️ انتشار #مقاله جدید با وابستگی کوتار
💠 Effects and safety of resveratrol supplementation in older adults: A comprehensive systematic review
👥 Sepideh Yadegar, Fatemeh Mohammadi, Amirhossein Yadegar, Ali Mohammadi Naeini, Aryan Ayati, Nesa Milan, Amirhossein Tayebi, Seyed Arsalan Seyedi, Seyed Ali Nabipoorashrafi, Soghra Rabizadeh, Alireza Esteghamati, Manouchehr Nakhjavani*
📔 Phytotherapy Research (Q1)
🗓 May 2024
🗂 Review
📄 Abstract: Resveratrol (RSV) has garnered significant attention in recent years due to its potential benefits against chronic diseases. However, its effects and safety in older adults have not been comprehensively studied. This study aimed to determine the effects and safety of RSV supplementation in older adults. MEDLINE/PubMed, Scopus, and Web of Science databases were comprehensively searched for eligible studies. Studies were enrolled if they were randomized clinical trials and had incorporated RSV supplementation for older adults. Two independent authors conducted the literature search, and eligibility was determined according to the PICOS framework. Study details, intervention specifics, and relevant outcomes were collected during the data collection. The Cochrane RoB-2 tool was used to evaluate the risk of bias. This review included 10 studies. The combination of RSV and exercise improved exercise adaptation and muscle function in healthy older adults and physical performance and mobility measures in individuals with functional limitations. RSV showed potential neuroprotective effects in patients with Alzheimer's disease. In overweight individuals, RSV demonstrated a positive impact on cognitive function, but it increased some biomarkers of cardiovascular disease risk at high doses. In older adults with diabetes and those with peripheral artery disease (PAD), RSV was not more effective than placebo. No study reported significant adverse events following RSV treatment. RSV can improve various health parameters in age-related health conditions. However, the optimal dosage, long-term effects, and potential interactions with medications still need to be investigated through well-designed RCTs.
🔗 http://dx.doi.org/10.1002/ptr.8171
📢 در صورتی که مقالهای با وابستگی کوتار چاپ کردهاید، لطفا با ارسال آن برای @COTAR_Support ما را آگاه کنید.
🆔 @COTAR_TUMS | 716 |
| 15 | ❇️ انتشار #مقاله جدید با وابستگی کوتار
💠 Genetic and Lifestyle Risk Factors of Metabolic Dysfunction-Associated Fatty Liver Disease and Its Relationship with Premature Coronary Artery Disease: A Study on the Pars Cohort
👥 Amir Anushiravani, Maryam Rayatpisheh, Amir Kasaeian*, Iman Menbari Oskouie*
📔 Archives of Iranian Medicine (Q1)
🗓 May 2024
🗂 Original research
📄 Abstract: The main objective of this study is to identify the risk factors of metabolic dysfunction-associated fatty liver disease (MAFLD) in coronary artery disease (CAD) patients. The present retrospective cohort study is part of the Pars Cohort Study (PCS). The participants were categorized as having MAFLD or not. The pattern of independent variables in patients was compared with those who did not have MAFLD. All variables were retained in the multivariable logistic regression model. Totally, 1862 participants with CAD were enrolled in this study. MAFLD was diagnosed in 647 (40.1%) participants. Gender, diabetes, hypertension, tobacco, opium, alcohol, age, weight, waist circumference, cholesterol, HDL, triglyceride, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were significantly different in MAFLD and non-MAFLD patients. Also, the results of multivariable logistic regression show male gender (OR=0.651, 95% CI: 0.470‒0.902, P value=0.01) and opium consumption (OR=0.563, 95% CI: 0.328‒0.968, P value<0.001) to be negative risk factors of MAFLD occurrence in CAD patients. Having diabetes (OR=2.414, 95% CI: 1.740-3.349, P value<0.001), high waist circumference (OR=1.078, 95% CI: 1.055‒1.102, P value<0.01), high triglyceride (OR=1.005, 95% CI: 1.001‒1.008, P value=0.006), and high ALT (OR=1.039, 95% CI: 1.026‒1.051, P value<0.01) were positive risk factors of MAFLD in CAD patients. Our study found that consuming opium decreases the likelihood of MAFLD in CAD patients, since these patients have decreased appetite and lower body mass index (BMI). On the other hand, female gender, having diabetes, high waist circumference, high triglyceride levels, and high ALT levels increase the probability of MAFLD in CAD patients.
🔗 https://doi.org/10.34172/aim.2024.36
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🆔 @COTAR_TUMS | 713 |
| 16 | ❇️ انتشار #مقاله جدید با وابستگی کوتار
💠 Sleep profiles in epilepsy patients undergoing monotherapy and polytherapy: A comparative cross-sectional study
👥 Alireza Arvin, Morvarid Taebi, Zahra Khazaeipour, Arezu Najafi, Abbas Tafakhori, Sakineh Ranji-Bourachaloo, Hamed Amirifard*
📔 Epilepsy & Behavior (Q2)
🗓 April 2024
🗂 Original research
📄 Abstract: Sleep disturbances commonly reported among epilepsy patients have a reciprocal relationship with the condition; While epilepsy and anti-seizure medications (ASMs) can disrupt sleep structure, disturbed sleep can also exacerbate the frequency of seizures. This study explored subjective sleep disturbances and compared sleep profiles in patients who underwent ASM monotherapy and polytherapy. We enrolled 176 epilepsy patients who completed a structured questionnaire containing demographic and clinical information and the Persian versions of the Pittsburgh Sleep Quality Index (PSQI), Insomnia Severity Index (ISI), Epworth Sleepiness Scale (ESS), and Patient Health Questionnaire-9 (PHQ-9) to evaluate sleep quality, insomnia, excessive daytime sleepiness (EDS), and depressive symptoms, respectively. Chi-square and Mann-Whitney U tests were employed to analyze the association between variables, and logistic regression analysis was conducted to identify factors predicting sleep disturbances. Comparative analysis of mono/polytherapy groups revealed a significantly higher prevalence of insomnia and EDS among patients on polytherapy compared to monotherapy. However, no significant difference was found in sleep quality between the two groups. Logistic regression analysis revealed that a depressive mood serves as a robust predictor for sleep issues, whereas treatment type did not emerge as an independent predictor of sleep disturbances. Our findings suggest that an increased number of ASMs does not inherently result in a higher incidence of sleep issues. Therefore, multiple ASMs may be prescribed when necessary to achieve improved seizure control. Furthermore, this study underscores the importance of comprehensive management that addresses seizure control and treating affective symptoms in individuals with epilepsy.
🔗 https://doi.org/10.1016/j.yebeh.2024.109799
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🆔 @COTAR_TUMS | 676 |
| 17 | ❇️ انتشار #مقاله جدید با وابستگی کوتار
💠 Machine Learning for prediction of violent behaviors in schizophrenia spectrum disorders: a systematic review
👥 Mohammadamin Parsaei, Alireza Arvin, Morvarid Taebi, Homa Seyedmirzaei, Giulia Cattarinussi, Fabio Sambataro, Alessandro Pigoni, Paolo Brambilla, Giuseppe Delvecchio*
📔 Frontiers in Psychiatry (Q2)
🗓 March 2024
🗂 Review
📄 Abstract: Schizophrenia spectrum disorders (SSD) can be associated with an increased risk of violent behavior (VB), which can harm patients, others, and properties. Prediction of VB could help reduce the SSD burden on patients and healthcare systems. Some recent studies have used machine learning (ML) algorithms to identify SSD patients at risk of VB. In this article, we aimed to review studies that used ML to predict VB in SSD patients and discuss the most successful ML methods and predictors of VB. We performed a systematic search in PubMed, Web of Sciences, Embase, and PsycINFO on September 30, 2023, to identify studies on the application of ML in predicting VB in SSD patients. We included 18 studies with data from 11,733 patients diagnosed with SSD. Different ML models demonstrated mixed performance with an area under the receiver operating characteristic curve of 0.56-0.95 and an accuracy of 50.27-90.67% in predicting violence among SSD patients. Our comparative analysis demonstrated a superior performance for the gradient boosting model, compared to other ML models in predicting VB among SSD patients. Various sociodemographic, clinical, metabolic, and neuroimaging features were associated with VB, with age and olanzapine equivalent dose at the time of discharge being the most frequently identified factors. ML models demonstrated varied VB prediction performance in SSD patients, with gradient boosting outperforming. Further research is warranted for clinical applications of ML methods in this field.
🔗 https://doi.org/10.3389/fpsyt.2024.1384828
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🆔 @COTAR_TUMS | 530 |
| 18 | ❇️ انتشار #مقاله جدید با وابستگی کوتار
💠 Challenges of Using C-Arm Fluoroscopy Systems: A Mixed Method Study Investigating Orthopedic Surgeons’ Experience
👥 Mobina Gharib, Shakiba Mohammadi*, Mohammadreza Mohammadi, Nastaran Maghbouli, Mohammad Hossein Nabian
📔 Journal of Iranian Medical Council (Q4)
🗓 March 2024
🗂 Original research
📄 Abstract: Intraoperative fluoroscopy systems are widely used nowadays, where their use allows a shorter duration of procedure time and better anatomical localization. The current study aims to investigate the most common challenges of C-arm fluoroscopy systems application. This mixed-method study was carried out in February and March 2022. After the literature review, a qualitative study was designed using semi-structured interviews to find important themes and subthemes required to design a web survey. The web survey was completed by the Persian Orthopedic Trauma Association (POTA) event’s international presenters. Nine orthopedic surgeons participated in interviews and 27 participants filled out the questionnaires. Five main themes including Physical Aspect, Mechanical Aspect, Software Options, Image Quality, and Radiation Exposure were extracted. Generally, over 80% of the web survey participants agreed that the size and shape of the base of C-arm fluoroscopy systems, C-arm diameter (space between tube and detector), and maneuvering and positioning of the C-arm fluoroscopy systems can interfere with surgical procedures. 100% of the participants agreed that providing two different views (e.g., AP and lateral) from the surgical site with one shot can be beneficial. The effectiveness of real-time visualization of radiation exposure on exposure rate was acknowledged by more than 92% of the participants. Although the C-arm fluoroscopy systems are widely used in surgical procedures, there are considerable issues regarding the application of this imaging modality in the operation room, and medical equipment companies should pay more attention to these issues to facilitate the use of these systems.
🔗 https://doi.org/10.18502/jimc.v7i2.15047
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🆔 @COTAR_TUMS | 525 |
| 19 | ❇️ انتشار #مقاله جدید با وابستگی کوتار
💠 Sex Dimorphism in Pain Threshold and Neuroinflammatory Response: The Protective Effect of Female Sexual Hormones on Behavior and Seizures in an Allergic Rhinitis Model
👥 Mohammad Elahi, Zahra Ebrahim Soltani, Arya Afrooghe, Elham Ahmadi, Ahmad Reza Dehpour
📔 Journal of Neuroimmune Pharmacology (Q1)
🗓 April 2024
🗂 Review
📄 Abstract: Our previous research demonstrated that allergic rhinitis could impact behavior and seizure threshold in male mice. However, due to the complex hormonal cycles and hormonal influences on behavior in female mice, male mice are more commonly used for behavioral tests. In this study, we aimed to determine whether these findings were replicable in female mice and to explore the potential involvement of sexual hormones in regulating neuroinflammation in an allergic model. Our results indicate that pain threshold was decreased in female mice with allergic rhinitis and the levels of IL-23/IL-17A/IL-17R were increased in their Dorsal root ganglia. However, unlike males, female mice with AR did not display neuropsychological symptoms such as learning and memory deficits, depression, and anxiety-like behavior. This was along with decreased levels of DNA methyl transferase 1 (DNMT1) and inflammatory cytokines in their hippocampus. Ovariectomized mice were used to mitigate hormonal effects, and the results showed that they had behavioral changes and neuroinflammation in their hippocampus similar to male mice, as well as increased levels of DNMT1. These findings demonstrate sex differences in how allergic rhinitis affects behavior, pain sensitivity, and seizure thresholds. Furthermore, our data suggest that DNMT1 may be influenced by sexual hormones, which could play a role in modulating inflammation in allergic conditions.
🔗 https://doi.org/10.1007/s11481-024-10114-0
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🆔 @COTAR_TUMS | 490 |
| 20 | ❇️ انتشار #مقاله جدید با وابستگی کوتار
💠 Intrathecal baclofen efficacy for managing motor function and spasticity severity in patients with cerebral palsy: a systematic review and meta-analysis
👥 Mahdi Masrour, Amir Zare, Ana Presedo*, Mohammad Hossein Nabian*
📔 BMC Neurology (Q2)
🗓 April 2024
🗂 Review
📄 Abstract: Spasticity can significantly affect a patient’s quality of life, caregiver satisfaction, and the financial burden on the healthcare system. Baclofen is one of only a few options for treating spasticity. The purpose of this study is to investigate the impact of intrathecal baclofen (ITB) therapy on severe spasticity and motor function in patients with cerebral palsy. We conducted a systematic review in PubMed, Scopus, Ovid, and the Cochrane Library in accordance with the PRISMA guidelines. We included studies based on eligibility criteria that included desired participants (cerebral palsy patients with spasticity), interventions (intrathecal baclofen), and outcomes (the Ashworth scales and the Gross Motor Function Measure [GMFM]). The within-group Cohen’s d standardized mean differences (SMD) were analyzed using the random effect model. We screened 768 papers and included 19 in the severity of spasticity section and 6 in the motor function section. The pre-intervention average spasticity score (SD) was 3.2 (0.78), and the post-intervention average score (SD) was 1.9 (0.72), showing a 40.25% reduction. The SMD for spasticity reduction was − 1.7000 (95% CI [-2.1546; -1.2454], p-value < 0.0001), involving 343 patients with a weighted average age of 15.78 years and a weighted average baclofen dose of 289 µg/day. The SMD for the MAS and Ashworth Scale subgroups were − 1.7845 (95% CI [-2.8704; -0.6986]) and − 1.4837 (95% CI [-1.8585; -1.1088]), respectively. We found no relationship between the participants’ mean age, baclofen dose, measurement time, and the results. The pre-intervention average GMFM (SD) was 40.03 (26.01), and the post-intervention average score (SD) was 43.88 (26.18), showing a 9.62% increase. The SMD for motor function using GMFM was 0.1503 (95% CI [0.0784; 0.2223], p-value = 0.0030), involving 117 patients with a weighted average age of 13.63 and a weighted average baclofen dose of 203 µg/day. In 501 ITB implantations, 203 medical complications were reported, including six new-onset seizures (2.96% of medical complications), seven increased seizure frequency (3.45%), 33 infections (16.26%), eight meningitis (3.94%), and 16 cerebrospinal fluid leaks (7.88%). Delivery system complications, including 75 catheter and pump complications, were also reported. Despite the risk of complications, ITB has a significant impact on the reduction of spasticity. A small but statistically significant improvement in motor function was also noted in a group of patients.
🔗 https://doi.org/10.1186/s12883-024-03647-7
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🆔 @COTAR_TUMS | 496 |
