Drug & Poison Information Channel
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It provides up to date, evidenced based, concised drug information to all health care professionals. Supervised by: Ph. Amal Al-Najjar. To communicate,participate and questions: @Amal_alNajjar.
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Channel Posts
| 2 | image_2026-07-03_23-42-50.png | 56 |
| 3 | https://pubmed.ncbi.nlm.nih.gov/42313397/ | 129 |
| 4 | 🚦Regulatory Alert: EMA & FDA Move to Revoke Avacopan (Tavneos)
Medicine: Tavneos (avacopan)
Class: Oral complement C5a-receptor antagonist
Indication: Severe, active Granulomatosis with Polyangiitis (GPA) or Microscopic Polyangiitis (MPA) in adults, alongside standard therapy.
The Update
The European Medicines Agency’s (EMA) committee has recommended revoking the EU marketing authorization for Avacopan, concluding its benefits no longer outweigh its risks. The US FDA is concurrently moving to withdraw the drug on the exact same grounds.
The Reason: Data Integrity, Not Safety
This transatlantic withdrawal is not triggered by a new adverse event, but by severe data integrity issues regarding the pivotal ADVOCATE trial (n=331) that originally supported its approval:
Evidence revealed that trial results were manipulated by unblinded personnel to make the drug appear effective.
The original data analysis did not support the conclusion of efficacy.
This original, unfavorable analysis was actively hidden from regulatory agencies during the initial approval process in 2021/2022. (EMA CHMP Article 20 Assessment Report (June 2026) & FDA Federal Register Proposal Notice (April 30, 2026)). | 148 |
| 5 | كيف نفهم أرقام الـ (Hazard Ratio) بشكل عام؟
إذا كان الـ HR يساوي 1: العلاجان متطابقان تماماً، ولا يوجد أي فرق في الخطورة بين المجموعتين.
إذا كان الـ HR أقل من 1 (مثل 0.58): العلاج الجديد أفضل، لأنه يقلل من احتمالية حدوث الشيء السيء (تفاقم المرض) ويطيل فترة استقرار المريض.
إذا كان الـ HR أكبر من 1 (مثلاً 1.5): العلاج الجديد أسوأ، لأنه يزيد من خطر تفاقم المرض بنسبة 50%. | 181 |
| 6 | *Dear Doctor,*
I would highly appreciate your participation in our research study titled: *“Effectiveness and Diagnostic Reliability of Tele-dermatology in Primary Care among Family Physicians in Riyadh, Saudi Arabia.”*
The survey takes approximately 3 minutes to complete and aims to assess Family physicians’ experiences with virtual dermatology consultations.
Participation is voluntary, and all responses are anonymous and confidential.
*survey link:*
https://forms.gle/PJVigwYeqcdas1Bx6
*Thank you for your valuable time and contribution.* | 216 |
| 7 | https://share.google/DDVcRiNiYAfzsMjy7 | 0 |
| 8 | No text... | 0 |
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