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👑 A 19-year-old patient with selective deficiency of an IgG subclass presents with recurrent pyogenic infections. Laboratory evaluation shows that the deficient subclass normally constitutes only a very small percentage of total IgG and is unique because it does not activate the classical complement pathway. Which of the following subclasses is deficient?
🔹A) IgG1
🔹B) IgG2
🔹C) IgG3
🔹D) IgG4
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🔹Each epitope can activate a different B lymphocyte clone.
-So the immune response against a whole microorganism usually produces many different antibodies.
-This is called a polyclonal antibody response.
-Polyclonal means: many B-cell clones are activated, and each clone produces antibody against a different epitope.
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🔹B cell → plasma cell → antibody secretion مهم
🔹Antibody specificity is toward a single epitope, not a whole organism.
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👑 Which pairing is INCORRECT?
🔹A) C3b — opsonization
🔹B) C5a — chemotaxis and mast cell degranulation
🔹C) C5b — initiation of MAC
🔹D) C9 — major opsonin
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💎 To be immunogenic, a substance must be
1-Recognized as foreign
2-Have chemical complexity
3-Sufficient size.
