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The most common manifestation of congenital rubella syndrome is sensorineural deafness (hearing loss).
The most common manifestation of congenital CMV infection in neonates is actually asymptomatic infection at birth. More than 90% of infected infants show no clinical signs initially.
In older children status epilepticus:
1st line: Benzodiazepine
Lorazepam IV 0.1 mg/kg preferred
If no IV: midazolam IM/IN/buccal 0.2 mg/kg
2nd line: Long-acting antiseizure drug
Fosphenytoin/phenytoin 20 mg/kg IV
OR
Levetiracetam 40–60 mg/kg IV
OR
Valproate 20–40 mg/kg IV
Before anticonvulsants in neonates, always correct:
Hypoglycemia
Hypocalcemia
Electrolyte disturbance
Infection if suspected
First-line: Phenobarbital
Second-line: Levetiracetam or Phenytoin/Fosphenytoin
Most common type of CP ✅spastic
Moct Common type of spastic ✅Diplagia
Presentation of patien
Lower limb effected more than upper
Dragging his feet behind him
scissor gait
More common in premature
the empirical antibiotic always a combination.
The combination is ceftriaxone and vancomycin
In the neonate, we use ceftazidime
Most common cause of hearing loss , H influenza
In the children more than six weeks old, we use dexamethasone
Most common cause in neonate group B Streptococcus
Most common cause in children Streptococcus pneumoniae
Most common cause of death in hours is Neisseria meningitidis
Most common late complication meningitis is SN deafness
In post-streptococcal glomerulonephritis (PSGN): do NOT routinely use prednisolone.
Treatment is mainly supportive:
Salt + fluid restriction
Furosemide for edema / hypertension
Antihypertensive if severe BP
Penicillin/amoxicillin to eradicate streptococcus, not to treat GN itself
Dialysis only if severe renal failure/overload
Exam summary:
• Isotonic dehydration → D5 NS + KCl
• Hyponatremic dehydration → D5 NS + KCl, avoid rapid Na correction
• Hypernatremic dehydration → NS bolus first, then D5 ½ NS + KCl, slow correction
Repost from Wizari by Abdulrahman
-بخصوص هذا السؤال:
- When physical positioning and calming measures fail, medical therapy is required.
- Phenylephrine is a pure alpha-1 adrenergic agonist. It causes potent vasoconstriction, which directly raises SVR. This shifts the pressure dynamics, forcing blood out of the right ventricle into the pulmonary circuit instead of escaping through the VSD into the aorta.
*** Morphine is often used to calm the patient and reduce tachypnea, but phenylephrine is the specific hemodynamic tool used to escalate SVR when positioning fails.
Repost from Wizari by Abdulrahman
⭐️ Hypercyanotic spells :
- The presentation describes a classic hypercyanotic "tet spell."
- The very first, least invasive, and most effective immediate action is to place the infant in a knee-to-chest position . This maneuver mechanically kinks the femoral arteries, sharply increasing Systemic Vascular Resistance (SVR).
The higher systemic pressure forces more blood through the right ventricular outflow tract into the lungs rather than shunting right-to-left across the VSD.
Repost from Wizari by Abdulrahman
An 8-month-old infant is brought to hospital actively experiencing a hypercyanotic spell. The emergency team immediately calms the child, administers high-flow oxygen via a non-rebreather mask, and places the patient in the knee-chest position. Despite these initial maneuvers for over 5 minutes, the infant remains profoundly cyanotic with an O2 saturation fluctuating between 55% and 60%, and is becoming increasingly obtunded. Intravenous access has just been successfully established.
Which of the following medications is considered the preferred next step to directly reverse the underlying pathophysiology of this persistent spell?
A) Intravenous Epinephrine
B) Intravenous Morphine sulfate
C) Intravenous Furosemide
D) Intravenous Phenylephrine
E) Intravenous Adenosine
