Pharmacology

Correct Answer - A Ans: A. Thiazide increases the tubular absorption of lithium Drug Interaction: Diuretics + Lithium = Decreased excretion—rise in Li + level - toxicity; Diuretics (thiazide, furosemide) by causing Na + loss to promote proximal tubular reabsorption of Na + as well as Li + → plasma levels of lithium rise. Potassium-sparing diuretics cause milder Li + retention. Management: Reduce dose of lithium and monitor level.

Correct Answer - B Ans. is 'b' i.e., Verapamil o Among the given options only verapamil has significant plasma protein binding (see text of the chapter).

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Correct Answer - A Ans: A. Thiazide increases the tubular absorption of lithium Drug Interaction: Diuretics + Lithium = Decreased excretion—rise in Li + level - toxicity; Diuretics (thiazide, furosemide) by causing Na + loss to promote proximal tubular reabsorption of Na + as well as Li + → plasma levels of lithium rise. Potassium-sparing diuretics cause milder Li + retention. Management: Reduce dose of lithium and monitor level.

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Correct Answer - D Ans. is 'd' i.e., Piroxicam Drugs used in acute gout NSAIDs Drug of choice Colehicine Corticosteroids

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