Pharmacology

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Correct Answer - B Ans. is 'b' i.e., Corticosteroid o Concurrent use of inhaled salmeterol with inhaled glucocorticoid produces effects equivalent to double dose of the corticoid alone.

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Correct Answer - D Ans. is 'd' i.e., Piroxicam Drugs used in acute gout NSAIDs Drug of choice Colehicine Corticosteroids

Correct Answer - A Ans. is 'a' i.e.. Water retention o PGE, causes increase in water excretion by inhibiting ADH action.

Correct Answer Is Vasopressin antagonist

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Correct Answer - D Ans. is 'a' i.e., More potent; 'c' i.e., Has little vasconstrictor activity o Desmopressin is longer acting o Desmopressin is V, selective -) No V, mediated vasoconstriction. o Desmopressin is 12 times more potent than vasopressin.

Central Drug Standard Control Organisation (CDSCO) regulates the clinical trials and approval of investigational new drugs in India. The proposal for initiating trials, review of clinical trial results and recommendations for marketing authorization is done through a committee called Investigational New Drug (IND) Committee formed by CDSCO. Preclinical trials are performed on animals, and they are regulated by guidelines prescribed by the Committee for the Purpose of the Control and Supervision of Experiments on Animals (CPCSEA) in India.

Inverse agonists are druas which have an affinity for a receptor, but the intrinsic activity opposite to that of an agonist. ◦ IA of an inverse agonist is between 0 and -1 The ability of the drug to bind with a receptor is called affinity. ◦ The capacity of a drug to induce a functional change in the receptor is called intrinsic activity or efficacy.