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Pharmacology
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تُعد قناة Pharmacology (@pharma_vid) في القطاع اللغوي الإنكليزية لاعباً نشطاً. يضم المجتمع حالياً 64 409 مشتركاً، محتلاً المرتبة 219 في فئة الطب والمرتبة 5 417 في منطقة الهند.
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Central Drug Standard Control Organisation (CDSCO) regulates the clinical trials and approval of investigational new drugs in India.
The proposal for initiating trials, review of clinical trial results and recommendations for marketing authorization is done through a committee called Investigational New Drug (IND) Committee formed by CDSCO.
Preclinical trials are performed on animals, and they are regulated by guidelines prescribed by the Committee for the Purpose of the Control and Supervision of Experiments on Animals (CPCSEA) in India.
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Inverse agonists are druas which have an affinity for a receptor, but the intrinsic activity opposite to that of an agonist. ◦ IA of an inverse agonist is between 0 and -1
The ability of the drug to bind with a receptor is called affinity. ◦ The capacity of a drug to induce a functional change in the receptor is called intrinsic activity or efficacy.
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A true statement regarding inverse agonist is that it
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Correct Answer - A
Ans: A. Thiazide increases the tubular absorption of lithium
Drug Interaction:
Diuretics + Lithium = Decreased excretion—rise in Li + level -
toxicity;
Diuretics (thiazide, furosemide) by causing Na + loss to promote
proximal tubular reabsorption of Na + as well as Li + → plasma
levels of lithium rise. Potassium-sparing diuretics cause milder Li +
retention.
Management: Reduce dose of lithium and monitor level.
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A patient on lithium therapy developed
hypertension. He was started on Thiazide
for hypertension. After a few days, he developed coarse tremors and other symptoms suggestive of lithium toxicity. What is the probable mechanism of interaction?
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Correct Answer - C
Ans: C. Chronic tophaceous gout
Pegloticase:
Pegloticase is a medication for the treatment of the severe,
treatment of refractory chronic gout.
It is a third-line treatment in those in whom other treatments are not
tolerated.
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Pegloticase is used for the treatment of
an Ankylosing spondylosis
