Pharmacology
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66 585
Correct Answer - A
Ans: A. Thiazide increases the tubular absorption of lithium
Drug Interaction:
Diuretics + Lithium = Decreased excretion—rise in Li + level -
toxicity;
Diuretics (thiazide, furosemide) by causing Na + loss to promote
proximal tubular reabsorption of Na + as well as Li + → plasma
levels of lithium rise. Potassium-sparing diuretics cause milder Li +
retention.
Management: Reduce dose of lithium and monitor level.
66 585
A patient on lithium therapy developed
hypertension. He was started on Thiazide
for hypertension. After a few days, he developed coarse tremors and other symptoms suggestive of lithium toxicity. What is the probable mechanism of interaction?
66 585
Correct Answer - B Ans. is 'b' i.e., Verapamil o Among the given options only verapamil has significant plasma protein binding (see text of the chapter).
66 585
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66 585
Correct Answer - A
Ans: A. Thiazide increases the tubular absorption of lithium
Drug Interaction:
Diuretics + Lithium = Decreased excretion—rise in Li + level -
toxicity;
Diuretics (thiazide, furosemide) by causing Na + loss to promote
proximal tubular reabsorption of Na + as well as Li + → plasma
levels of lithium rise. Potassium-sparing diuretics cause milder Li +
retention.
Management: Reduce dose of lithium and monitor level.
66 585
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A patient on lithium therapy developed
hypertension. He was started on Thiazide
for hypertension. After a few days, he developed coarse tremors and other symptoms suggestive of lithium toxicity. What is the probable mechanism of interaction?
66 585
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66 585
Correct Answer - D
Ans. is 'd' i.e., Piroxicam
Drugs used in acute gout
NSAIDs Drug of choice
Colehicine
Corticosteroids
66 585
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