stuff 🩷

Mode of killing NK >ADCC Mode of killing Cytotoxic t cell CD8+ >hit&run

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مهمة تجي All except :

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🚨 MCQ ALERT Macrophages are NOT MHC restricted. Macrophages kill tumor cells by nitric oxide, TNF-α, and respiratory burst. Macrophages express Fc receptors and mediate ADCC. IFN-γ activates macrophages.

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توضيح سلايد 3 و مهم جدا ايضا 🔹Tumor markers = tumor products (tumor antigens, enzymes, hormones). 🔹Released into: 🪽 Blood (serum) 🪽 Urine 🔹Uses: 🪽 Confirm diagnosis 🪽 Monitor response to treatment 🪽 Detect recurrence after therapy

Primary liver cancer مهم

✨TSTA (tumour specific transplantation antigen) 🔹PSA (Prostate specific antigen) ✨ TATA (tumour associated transplantation antigens) 1-🔹AFP (Alpha-fetoprotein) → Primary liver cancer (Hepatocellular carcinoma) 🔹AFP can also be elevated in: → Testicular cancer → Ovarian cancer → Gastric cancer → Pancreatic cancer → Liver cirrhosis&hepatitis 2-🔹CEA (Carcinoembryonic antigen) → Colorectal cancer → Pancreatic cancer →Liver cirrhosis&Chronic lung disease ✨Tumour associated viral antigens 🔹Papova & Herpes viruses

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انتبهوا الMetabolic rate يزيد +++ مو يقل

🪽 BCL-2 = Anti-apoptotic gene 🪽 Normal job: Keeps cells alive when needed. 🪽 Overexpression: Cancer cells refuse to die. 🪽 Associated with: Cell expansion > Follicular lymphoma

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مهم 🔹P53 is a tumor suppressor gene. (Growth inhibiting) 🪽 More than 50% of → Breast cancer → Ovarian cancer have P53 mutations.

🪽 Herpes virus II (HSV-2) → Carcinoma of cervix 🪽 Cytomegalovirus (CMV) → Nasopharyngeal carcinoma

توضيح سلايد 3 بالتعليقات

حدز 3 صور و اذا بيهم شي مهم او ملاحظة حدزها علمود لتصير هوسة

حبدي بالكانسر بس محمشي عالملاحظات لان الملزمة اصلا متروسة حجي