Chris Masterjohn, PhD
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Nutrition science education and independent COVID analysis. Free speech, bodily autonomy, and medical freedom.
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Kanal postlari
Bananas are a fantastic source of vitamin B6.
B6 is needed for mental health, enabling calmness instead of irritability, happiness instead of depression, low anxiety and good sleep.
B6 is needed to strengthen your mucosal and skin barriers, preventing redness, itching, and candida and yeast infections.
B6 is needed for beautiful skin, hair, and nails.
Most B6 in most plant foods is bound to sugars in bonds that you can’t digest.
Animal foods are much better sources of B6 than plants but cooking them causes the B6 to get stuck to the protein in bonds that you cannot digest, docking them by 40%.
Bananas have neither problem: very little of their B6 is bound to sugars and nearly everyone always eats them raw.
Blueberries are a great source of manganese, but people eating plant-heavy diets don’t need more manganese and many of them are veering into the mildly toxic range.
Bananas and blueberries are both good sources of potassium but to get enough potassium you need to focus on heavy volume of potassium-rich foods, not selection of one serving of a superfood.
If you are heavily plant-based and drinking a lot of smoothies you should add banana to them.
If you are forced to choose between bananas and blueberries in this context, choose bananas.
However, consider eating a rare steak.
And if you only eat rare steak, you are probably deficient in manganese. Consider some blueberries.
| 2 | Natural Alternatives to Benzodiazepines
Part 2 of 4 of the Benzodiazepine Series
Benzodiazepines are marketed (informally) as “psych meds” as if they primarily act on anxiety and stimulation circuits in the brain, but there is no such thing as a “psych med” because there are no targets that are only found in the brain and because there are no drugs that when taken orally primarily go to the brain.
They have the highest relative uptake into the adrenal gland and they have the highest absolute uptake into muscle and fat.
They probably act on GABA receptors found widely outside of the nervous system. While they are not active on the unique GABA receptors in the liver, they are probably active at GABA receptors on the lungs, kidneys, immune cells, reproductive organs, and pancreas.
GABA itself regulates mitochondrial metabolism indirectly, but benzodiazepines have two independent mitochondrial targets that lie directly in the mitochondrial membrane and are unrelated to their actions on GABA receptors.
There is no evidence that benzos are more powerful regulators of GABA metabolism than of mitochondrial metabolism. In fact, their solubility in fat and cell membranes might make them much more efficient at accessing their mitochondrial targets than at accessing GABA receptors.
Like SSRIs, benzos are whole-body mitochondrial drugs.
As with SSRIs, benzos are playing with mitochondrial fire.
People who use benzos have 60% greater mortality per unit time than people who don’t, but people who quit them have 60% greater mortality per unit time than people who stay on them. We cannot say whether these trends represent causation. However, they raise the possibility that benzo use puts one between a rock and a hard place and emphasize that the safest position is gained by never using them in the first place if their use can be safely avoided.
This article covers alternatives to benzos following the hierarchy derived from The Five Laws of Mitochondrial Health.
This is not an article about how to treat anxiety, insomnia, seizures, spasms, alcohol withdrawal, and related forms of overstimulation without benzos. This is because each of these problems is far broader than activating GABA receptors.
This is, instead, an article on how to do what benzos do using food-first strategies that are do not pose the same tradeoffs and risks as drugs.
Strategies are included for one or both of two reasons: either they have clear evidence of increasing GABA or GABA activity and also have evidence of clinical benefit in humans; or they have head-to-head comparisons with benzodiazepines against some clinical endpoint suggesting comparability or non-inferiority.
These strategies can be a component to healthfully handling anxiety, insomnia, seizures, spasms, alcohol withdrawal, and related forms of overstimulation, but not the whole approach to any of them.
Read the article here:
https://chrismasterjohnphd.substack.com/p/natural-alternatives-to-benzodiazepines | 391 |
| 3 | TOMORROW!
If you live in Kentucky, vote for this guy.
If you know someone in Kentucky, tell them to go vote.
If you don’t, donate to his campaign.
Massie is the only good person in the House.
Contrary to the view that he’s an obstructionist who gets nothing done, he successfully campaigned against the BBB getting a 10-year override on the ability of states to regulate AI, which directly protects your ability to locally keep them out of your own back yard or prevent them from starving you of electricity.
His PRIME Act helped keep small innovative farms alive by taking away USDA from being too high a barrier to entry and keeping health inspections local for people who sell locally.
Massie was instrumental in getting the Epstein files released.
The Epstein billionaires are trying to flush out their last principled critic.
Don’t let them.
Photo of me and him is from October 26, 2024 at the Weston A Price Conference where he was giving the keynote address. | 365 |
| 4 | NEW Study: Fetuses with prenatal SSRI exposure have brain & placental alterations seen on in utero MRI (PMID: 42106476).
No one will EVER make sense of this until they realize that
1) THE role of serotonin is to adjust ALL mitochondria to situations of absolute or relative hypoxia both inside the body and throughout every tissue of the body.
2) SSRIs block half of this because it requires both extracellular and mitochondrial serotonin receptors and serotonin entry into the mitochondria and SSRIs prevent serotonin from entering the cell and then into the mitochondria.
3) The placenta has the HIGHEST expression of the serotonin transporter.
4) In pregnant women THE GREATEST effect of SSRIs is to deprive the fetus of placentral serotonin transport.
5) This is because until the baby is born it is in a CONSTANT STATE OF HYPOXIA not because of absolute deprivation of oxygen but because its source of oxygen is not its lungs and therefore its oxygen delivery has to be completely rewired until this is suddenly reversed the second it is born.
and
6) SSRIs are therefore drugs that induce mitochondrial dysfunction in babies. | 836 |
| 5 | I think more specific data will provide insights that they can use to convert the vicicous mitochondrial cycles to virtuous mitochondrial cycles and I hope and pray for Jordan’s robust and lasting recovery. | 475 |
| 6 | What's Wrong With Jordan Peterson's Health?
Jordan Peterson’s health has been suffering tremendously.
Mikhaila, his daughter, saw that what was ailing him was affecting so many systems of his body that it had to all be connected and began to wonder if it was a form of mitochondrial dysfunction.
In trying to research whether mitochondrial dysfunction could be driven by the turning points in his health problems like SSRI withdrawal, benzodiazepine withdrawal, and toxic mold, she found my work and reached out to me.
This is the conversation that we had:
https://www.youtube.com/watch?v=MFhBq2Qlbto
My hypothesis is as follows.
Mikhaila shares half of Jordan’s genes and has been more detailed about her own health journey going back to childhood, so we start with her.
She had juvenile arthritis symptoms starting at 2 and a diagnosis at 7. She went on Enbrel, a “biologic” (a pseudoscientific regulatory term) that opposes the action of the inflammatory mediator tumor necrosis alpha (TNF-alpha); and on methotrexate, which inhibits folate and adenosine metabolism. Methotrexate raises adenosine, which inhibits T cell proliferation. Its inhibition of folate metabolism is thought to be more relevant to cancer but its adenosine-mediated inhibition of T cell proliferation is thought to be more relevant to autoimmune arthritis.
The next year, at age 8, she was diagnosed with depression and put on SSRIs.
My hypothesis is that she has an underlying block in mitochondrial metabolism leading to CoA sequestration, which occurs when CoA-requiring pathways fail to complete properly. This leads to secretion of TNF-alpha as part of a cellular stress response. TNF-alpha serves to increase carnitine transport into the cell. The carnitine then trades places with CoA, detoxifying the metabolic intermediates and carrying them out into the urine, allowing CoA metabolism to continue.
Blocking the TNF-alpha is a double-edged sword. On the one hand, the elevated TNF-alpha will interact with genetic predispositions to certain types of immune dysfunction and with suboptimal joint mechanics to produce an autoimmune disease. Blocking the TNF offers relief from the autoimmunity, but then in doing so makes the cells that were releasing it as a stress signal unable to mitigate their CoA sequestration. This may lead to a plethora of side effects, and for Mikhaila this was depression.
I do not discount that inhibition of folate metabolism by methotrexate could have messed with her methylation system, but Mikhaila remains very intolerant of methylfolate and thrives on a low-folate all-meat diet, and I do not think any of her health problems are explained merely by a methylation deficit.
Her first major advance was going on an elimination diet that eventually morphed into the red meat carnivore “Lion Diet.”
T cells are fueled by glucose and glutamine during active inflammation, and when they transition to resolving inflammation a major drop in glucose and glutamine is a central hallmark of the metabolic shift.
The zero-carb nature of the Lion Diet helps resolve T cell inflammation and displaces the need for methotrexate.
The large amount of red meat provides carnitine, which addresses CoA sequestration from the point of carnitine supply, relieving the need of cells to secrete TNF-alpha to signal carnitine demand. The carnitine in the red meat thereby helps relieve the need for the Enbrel.
Since her elimination diet gave her the first relief of depression she had experienced, it led her to go off the SSRIs.
Going off SSRIs produced 2.5 years of new-onset neurological dysfunction, which I contend was new-onset mitochondrial dysfunction. This may have interacted or blended with the mitochondrial dysfunction that initially led to the arthritis, or it may have just been a completely new acquired mitochondrial disorder thrown on top of the existing problems. | 404 |
| 7 | Throughout this story, various exposures to toxic mold occurred that made her problems worse, including one in 2022 that gave her a whole new list of problems that only moving away from the mold was able to solve. Mold toxins are mitochondrial toxins, so exposure to them would cause a third layer of mitochondrial dysfunction.
Jordan had been on SSRIs for over twelve years, but when he saw Mikhaila cure her depression with the early precursor to the Lion Diet, he followed her approach. Having gotten rid of his own depression, he too went off SSRIs around the same time as she did. This led to akathisia, a catastrophically debilitating movement disorder. I contend that this is SSRI withdrawal-induced new-onset mitochondrial dysfunction.
He then had a terrible reaction to apple cider that had sodium metabisulfite as a preservative. This led him to be unable to sleep for two or three weeks. He became green and hunched over, and couldn’t walk.
For this he was placed on clonazepam, a benzodiazepine.
Sulfite has to be converted to sulfate, which requires the mineral molybdenum and the transfer of electrons from the sulfite to the mitochondrial respiratory chain.
Mitochondrial dysfunction will prevent sulfite clearance.
Zero-carb diets will increase endogenous sulfur production and diets that lack liver and legumes are low in molybdenum.
The mitochondrial dysfunction induced by the SSRI withdrawal would inhibit sulfur clearance and the diet that helped Jordan and Mikhaila cure their depression would keep the sulfur-detoxification system maximally occupied.
If sulfite is not quickly metabolized to sulfate, it converts to S-sulfocysteine, which is a neurotransmitter that activates glutamate receptors.
Sulfite itself is mitochondrially toxic, so if it crosses a critical threshold it can elicit a storm of excess sulfur catabolism and impaired sulfur clearance that keeps S-sulfocysteine levels high. That vicious cycle could explain why the sleep loss lasted 2-3 weeks.
Clonazepam directly opposes S-sulfocysteine in that it binds to GABA receptors making GABA more powerfully activate them, which counteracts the S-sulfocyteine’s activation of glutamate receptors.
Peterson stayed on clonazepam for three years and then tried going off of it, but this caused an even worse case of akathisia than he experienced from SSRI withdrawal. It lasted three years, and it made him suicidal.
Clonazepam can alter calcium signaling in mitochondria in opposite ways depending on the preexisting state of the mitochondrial function. Possible effects of withdrawal include a catastrophic energetic supply/demand imbalance and precipitation of calcium causing damaging deposits that jam up the mitochondrial infrastructure. It is very possible that the clonazepam was causing progressive mitochondrial dysfunction the entire time he was on it and that it only became apparent once the GABA breaks on energy demand were removed by withdrawal.
He briefly restarted an SSRI during this time but it didn’t help and it made him so fatigued he needed four extra hours of sleep per day.
Ultimately, the final version of the all-meat Lion Diet helped Jordan recover from akathisia.
More recently, however, his parents died and he had been cleaning out their moldy basement preparing for a big move, and this led to an attack of pneumonia and sepsis and a return of his akathisia.
The mitochondrial toxins in the mold thus became his third acquired mitochondrial disorder, the first two from withdrawal from SSRIs and benzodiazepines.
Jordan and Mikhaila share a lot in their health history but her mom has none of these problems and has never been on SSRIs. Thus, it is very likely there are genetic predispositions to these problems that Jordan and Mikhaila share.
The Lion Diet is overall extremely helpful but could probably benefit from specific strategies around managing sulfur metabolism.
I will do what I can to help them, starting with looking at their mitochondrial function. | 238 |
| 8 | The Five Laws of Mitochondrial Health
Living in accordance with these laws keeps us on the path to vibrant health.
We defined health.
We’ve put our sights on the North Star.
We know how to know when we’re healthy.
But what do we do to get there?
If we have arrived at the promised land, how do we stay there?
How do we explore it more deeply to discover the riches of its treasures?
What Everyone Should Be Doing For Their Health is a collection of “the basics” that everyone should check in on from time to time to make sure they aren’t missing any of the foundational health strategies.
But what if you’re missing many of the basics? Where should you start? How should you narrow in your focus?
Or what if you’re hitting them all and you need a more advanced health strategy? How do you guide your search?
The Five Laws of Mitochondrial Health
The Five Laws of Mitochondrial Health are the compass you need to keep you following your North Star.
They are the lenses with which you should view the basics.
They are the guardrails that keep you on solid footing as you search for your next advanced strategy.
These are the Five Laws of Mitochondrial Health:
The First Law: Always start with your mitochondria.
The Second Law: Put food first and pharma last.
The Third Law: Never put tech before nature.
The Fourth Law: Remember your needs are your own.
The Fifth Law: Observe your needs as they change with time.
Applying these five laws will require specific mitochondrial strategies and a plethora of mitochondrial tactics.
Our purpose in this article, however, is to understand the laws so that when we seek to apply them using strategies and tactics we do so from a position of wisdom and understanding.
This is educational in nature and not medical or dietetic advice. See terms for additional and more complete disclaimers.
This is a fundamentally philosophical article, so it focuses on articulating the philosophy rather than on substantiating claims with evidence from scientific literature.
The 1st Law: Always Start With Your Mitochondria
Mitochondria extract usable energy from the food you eat so you can use it to fuel the production, maintenance, repair, and distribution of everything in your body.
The amount of cellular energy your mitochondria produce drives the dial of health and disease.
As you produce more energy, the dial drives to the right and points to health.
As you produce less energy, it falls back to the left and points toward disease.
Within each range, the amount of cellular energy drives how ill we are or how healthy we are.
There are thousands of genetic variants and uncountable experiences and exposures that can drive what disease or health looks like for each one of us.
For one person, disease is diabetes. For another, it’s heart disease. For another, it’s cancer. For yet another, it’s a neurological disease. And for yet another, it’s chronic fatigue.
For one person, peak health is athletic achievements. For another, it’s business. For yet another, it’s leadership and the formation of harmony within a community. And for yet another, it’s contemplation of eternal truths and their articulation in art or writing or speech.
But whether we experience health or disease and how much of each we experience comes down to how much usable energy we can extract from food and to what extent we can use the top layer of abundant energy to fuel the commitment of the bulk of the energy toward our health and highest purpose.
Living in accordance with the first law can be achieved at many levels: one level applies to how we manage our own health; another applies to how a physician may manage the health of others; yet another applies to the scientists who study how the many things we could be exposed to impact our health.
For example, using or prescribing mitochondrially toxic antibiotics for acne before giving the skin enough vitamin B5 to allow its mitochondria to clear away the fatty acids that are fueling the growth of those bacteria violates the first law.
Consider high cholesterol. | 230 |
| 9 | Training the liver’s mitochondria to produce abundant energy through fasting and intense exercise will improve the ability of the liver to fuel the energy-intensive clearance of cholesterol from the blood. To do this before resorting to strategies focused exclusively on micromanaging the production of the cholesterol transporters with fiber, ezetimibe, seed oils, and statins is to live in accordance with the first law.
A scientist trying to solve the protracted withdrawal syndromes of benzodiazepines and SSRIs by focusing exclusively on neurotransmitters does not walk in the way of the first law. To walk in its way, the scientist must consider how these drugs distribute through the entire body, entering cells in every tissue and altering their mitochondria.
Read the full article here:
https://chrismasterjohnphd.substack.com/p/the-five-laws-of-mitochondrial-health | 287 |
