شرح محاضرات الصيدلة

ملخص المحاضرة 7 // ملاحظة// هاي فقط الملاحظات المهمة وانتو هم اقروا المحاضرة **functiun of innate immune sys. ➡️ 1)recognize pathogene associated molecules (stimulants) 2) trigger inflammatory response & phagocytosis response ** phagocytes (neutrophils & macrophages) function ➡️ phagocytosis ** dendritic cell function ➡️ activate T. cell of adaptive sys. ** receptors types ➡️ 1) soluble receptor in blood ( complement receptor ) 2)membrane bound receptor ( Toll-like) **complement receptor function ➡️ 1) aid in phagocytosis and direct killing of pathogen 2) amplify action of antibody **Toll-like receptor function ➡️ 1) initiate phagocytosis 2)activate program of gene expression ** complement activation by three pathways : 1) classical pathway ➡️ antibody binding 2) lectin pathway ➡️ mannan bunding 3) alternative pathway ➡️ pathogen surface **in classical pathway➡️ ** early complement activate C3 **early complement activated by proleolytic cleavage **small complement (small fragment ) called…